Antihypertensive Effects of Flavonoids Isolated from Brazilian Green Propolis in Spontaneously Hypertensive Rats

Maruyama, Haruhiko; Sumitou, Yoshiki; Shimoyama, Takashi; Araki, Yasufumi; Hara, Hideaki

doi:10.1248/bpb.32.1244

Cited by 60 publications

(51 citation statements)

References 23 publications

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“…The flavonoids in Brazilian green propolis have vasodilating effects [26], and the flavonoid quercetin has been reported to be effective against hypertension in animals and humans [27]. These findings of the efficacy of flavonoids in hypertension support the results in our study.…”

Section: Discussionsupporting

confidence: 90%

Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice

et al. 2010

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Kaempferia parviflora Wall. Ex Baker (KP) has been used as a folk medicine in Laos and Thailand to lower blood glucose levels, improve blood flow, and increase vitality. This study investigated the preventive effects of KP on obesity and its downstream symptoms (various metabolic disorders) using Tsumura, Suzuki, Obese Diabetes (TSOD) mice, a multifactorial genetic disease animal model in which metabolic diseases develop spontaneously, similar to metabolic syndrome in humans, and Tsumura, Suzuki, Non-Obesity (TSNO) mice as the corresponding control mice. When feed that was mixed with KP (1 or 3%) was given ad libitum to TSOD and TSNO mice for 8 weeks, body weight increase, visceral fat accumulation, lipid metabolism abnormalities, hyperinsulinemia, glucose intolerance, insulin resistance, hypertension, and peripheral neuropathy were suppressed in TSOD mice, but no marked differences were observed in TSNO mice. Because KP had preventive effects on metabolic diseases, including antiobesity effects, only in obese animals, we propose that KP will be extremely valuable as a medicine or component of food in alternative health care.

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Section: Discussionsupporting

confidence: 90%

Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice

et al. 2010

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“…The presented study scientifically proves the traditional use of Melilotus officinalis (L.) Pallas in hypertension [5]. The coumarin glycosides [17] and flavonoids [18,19] possess antihypertensive activity. Chemicaly Melilotus officinalis contains coumarin glycosides [7] and flavonoids [4].…”

Section: Resultssupporting

confidence: 58%

Hypotensive Activity of Melilotus Officinalis (L.) Pallas

Anwer¹,

Shamim²,

Ahmed³

et al. 2015

European Journal of Medicine. Series B

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Melilotus officinalis (L.) Pallas., is used traditionally to treat hypertension and chronic venous insufficiency. The high prevalence of hypertension and the side effects of antihypertensive drugs potentiate us to evaluate Melilotus officinalis. The hypotensive effect of Melilotus officinalis butanolic fraction (MOBF) was investigated in anaesthetized normotensive rats. The doses of 60, 80 and 100 mg/kg, i.v., produced a significant (P<0.05) decrease in blood pressure. The statistically non significant reduction in blood pressure was showed by 20 and 40 mg/kg, i.v. These results suggest that Melilotus officinalis exhibited hypotensive effect in normotensive rats. However further evaluation of compound related activity is required.

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“…In Japan, Brazilian green propolis has recently come to be used as a health food, which is of sufficiently good quality to provide experimental reproducibility. The ethanol extract of propolis is the major form used in health food 14 . We also further investigate whether autophagy is involved in the neuroprotection of kaempferol and kaempferide against mutant SOD1-related neurotoxicity via the AMP-activated protein kinase (AMPK) - the mammalian target of rapamycin (mTOR) pathway.…”

Section: Introductionmentioning

confidence: 99%

The effects of Brazilian green propolis that contains flavonols against mutant copper-zinc superoxide dismutase-mediated toxicity

Ueda

Inden

Shirai

et al. 2017

Sci Rep

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective and progressive loss of motor neurons. The purpose of this study was to clarify effects of brazilian green propolis and the active ingredient against ALS-associated mutant copper-zinc superoxide dismutase (SOD1)-mediated toxicity. Ethanol extract of brazilian green propolis (EBGP) protected N2a cells against mutant SOD1-induced neurotoxicity and reduced aggregated mutant SOD1 by induction of autophagy. Kaempferide and kaempferol, the active ingredients of EBGP, also inhibited mutant SOD1-induced cell death and reduced the intracellular mutant SOD1 aggregates. Both kaempferide and kaempferol significantly suppressed mutant SOD1-induced superoxide in mitochondria. Western blot analysis showed that kaempferol potentially induced autophagy via the AMP-activated protein kinase (AMPK) - the mammalian target of rapamycin (mTOR) pathway. These results suggest that EBGP containing the active ingredient against mutant SOD1-mediated toxicity is a promising medicine or health food for prevention and treatment of ALS.

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Antihypertensive Effects of Flavonoids Isolated from Brazilian Green Propolis in Spontaneously Hypertensive Rats

Cited by 60 publications

References 23 publications

Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice

Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice

Hypotensive Activity of Melilotus Officinalis (L.) Pallas

The effects of Brazilian green propolis that contains flavonols against mutant copper-zinc superoxide dismutase-mediated toxicity

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