Antihypertensive effects of the hydro-ethanol extract of Senecio serratuloides DC in rats

Tata, Charlotte Mungho; Sewani-Rusike, Constance R; Oyedeji, Opeoluwa O.; Gwebu, Ephraim T.; Mahlakata, Fikile; Nkeh-Chungag, Benedicta N.

doi:10.1186/s12906-019-2463-2

Cited by 13 publications

(12 citation statements)

References 49 publications

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“…Some documented pharmacological applications of medicinal plants include antioxidant [4], anti-inflammatory [5], hypolipidemic [6], antidiarrheal [7], anti-proliferative [8,9], antihypertensive [10], neuroprotective [11], hepatoprotective [12], nephroprotective [13,14], antidiabetic [15], anti-ulcer [16,17], gastroprotective [18,19], haematopoietic [20] and many more.…”

Section: Introductionmentioning

confidence: 99%

Sub-acute toxicity of Caladium bicolor (Aiton) leaf extract in Wistar rats

Omotoso¹,

Brown²,

Okojie³

2020

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Herbal medicinal plants constitute an integral component of plant biodiversity whose application for therapeutic purposes has been a common practice since antiquity. However, studies have reported tissue pathologies following exposure to herbal medicinal plants or extracts. This study was carried out to assess the possible pathological effects of sub-acute exposure of methanol extract of Caladium bicolor on the hepatic histomorphology of experimental Wistar rats. Twenty four Wistar rats were divided into four groups A-D. Group A was administered with distilled water (2 ml/kg b.w) and groups B-D administered with 100 ml/kg, 200ml/kg and 300ml/kg b.w. of the extract respectively for twenty eight days. The bodyweight of experimental animals was recorded at regular intervals during the study period. After the treatment period, hepatic tissue was harvested, weighed and processed for histopathological study. The results showed that exposure to the extract causes significant (p<0.05) body and organ weight reduction, a significant increase in serum level of ALT and AST as well as prominent hepatic histopathological changes such as inflammation, necrosis and steatosis. Sub-acute exposure to methanol extract of C. bicolor thereby causes dose-independent hepatopathy in experimental animals. Hence, its application for therapeutic purposes needs to be re-evaluated and preferably discontinued to avoid these associated hepatic tissue pathologies.

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Section: Introductionmentioning

confidence: 99%

Sub-acute toxicity of Caladium bicolor (Aiton) leaf extract in Wistar rats

Omotoso¹,

Brown²,

Okojie³

2020

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“…Senecio serratuloides is also used singly or in combination with other plants to treat wounds such as cuts, internal and external sores (including those resulting from sexually transmitted infections), burns, swollen gums and chest pain (De Wet, Nciki, & van Vuuren, 2013;De Wet, Nzama, & Van Vuuren, 2012;Fawole et al, 2010;Gould, Penny, Patel, & Candy, 2015). A study in our laboratory reported the antihypertensive effect of the hydoethanolic extract of S. serratuloides (Tata et al, 2019). The plant has also been reported to have phenols, tannins, flavonoids, and gallotannins and to possess antiinflammatory, anticholinesterase, antioxidant, and wound healing properties (Fawole et al, 2010;Gould et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Fractionation and bioassay-guided isolation of antihypertensive components of Senecio serratuloides

et al. 2020

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Senecio serratuloides commonly referred to as "two day cure" is used in folk medicine for treating hypertension and wounds in South Africa. This study was aimed at isolating and testing the antihypertensive effects of bioactive compounds from S. serratuloides. Senecio serratuloides was serially extracted using solvents of increasing polarity. Phytochemical analysis, antioxidant capacity and antihypertensive properties of fractions were investigated. Bioactive compounds were isolated from ethyl acetate and methanol fractions, their antihypertensive effects and effect on urine norepinephrine concentration were determined. Ethyl acetate and methanol fractions had all eight phytochemicals tested, better antioxidant capacity and significantly (p < 0.001) prevented the increase in blood pressure induced by N ω -Nitro-L-arginine methyl ester hydrochloride. The isolated bioactive compounds were phytosteroids and Estran-3-one, 17-(acetyloxy)-2-methyl-, (2à,5à,17á)which was isolated from methanol fraction had significantly (p < 0.001) better antihypertensive effects through the 4-h period of the study. Senecio serratuloides may be a potential source of antihypertensive lead compounds.

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“…Then, AEAL antihypertensive effect might be due to its antioxidant properties since it is well document that the principal mechanisms in L-NAME-induced hypertension is oxidative stress but also to AEAL capacity to inhibit PDEs localized in the vascular smooth muscle cells. 9 , 36 , 60 , 67 , 68 Indeed, previous studies indicate that extract from Anogeissus leiocarpa has confirmed this potential antioxidant activity. 69–71 …”

Section: Discussionmentioning

confidence: 61%

Preclinical Evaluation of the Antihypertensive Effect of an Aqueous Extract of Anogeissus leiocarpa (DC) Guill et Perr. Bark of Trunk in L-NAME-Induced Hypertensive Rat

Belemnaba¹,

Nitiéma²,

Ilboudo³

et al. 2021

JEP

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Background The present study investigates the effect of an aqueous extract of Anogeissus leiocarpa (AEAL) on normotensive Wistar rats and its chronic antihypertensive effects in L-NAME-induced hypertensive rats by using a non-invasive tail-cuff model. Methods The effects of AEAL (50mg/kg) and NaCl 0.9% on blood pressure were investigated by daily oral administration in normotensive Wistar rats over four weeks. L-NAME-induced hypertensive rats were produced by L-NAME (40mg/kg) daily oral administration for two weeks. For chronic antihypertensive effects, induced hypertensive rats have received L-NAME in combination with AEAL (10 or 50mg/kg/day) for two following weeks. Results In normotensive rats, daily administration of AEAL (50mg/kg) has no significant effect on their blood pressure, which was similar to that of the control group. L-NAME’s daily oral administration induces a progressive increase in systolic blood pressure (SBP) from 115.8 ± 7.9mmHg to 153.5 ± 4.6mmHg after two weeks, which was maintained to the end of the treatment. In L-NAME-induced hypertensive rats, AEAL (50mg/kg/day) significantly decreases the SPB from 160.0 ± 5.8 mmHg to 108.8 ± 2.7mmHg after only four days of administration. However, the lower dose of AEAL (10mg/kg) also normalized the SBP of L-NAME-induced hypertensive rats but only evident after seven days of administration. Moreover, AEAL does not effect on the serum biochemical parameters (ALAT, ASAT, CREAT, etc.) and any macroscopic adverse effect was detected on the sensible organs involved during hypertension. In the aorta rings from treated rats, AEAL (50mg/kg/day) alone or in combination with L-NAME has enhanced the vasodilation effect of acetylcholine. However, the vasodilation effect of AEAL alone or in association with L-NAME has enhanced the sodium nitroprusside effect in treated rat aorta rings after autopsy. Conclusion These findings suggest that AEAL affords significant antihypertensive effects against L-NAME-induced hypertensive rats without modification of serum parameters and deleterious effects.

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Antihypertensive effects of the hydro-ethanol extract of Senecio serratuloides DC in rats

Cited by 13 publications

References 49 publications

Sub-acute toxicity of Caladium bicolor (Aiton) leaf extract in Wistar rats

Sub-acute toxicity of Caladium bicolor (Aiton) leaf extract in Wistar rats

Fractionation and bioassay-guided isolation of antihypertensive components of Senecio serratuloides

Preclinical Evaluation of the Antihypertensive Effect of an Aqueous Extract of Anogeissus leiocarpa (DC) Guill et Perr. Bark of Trunk in L-NAME-Induced Hypertensive Rat

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