Antihypertensive Role of Polyphenols

Rodrigo, Ramón; Gil, David; Miranda-Merchak, Andrés; Kalantzidis, Georgios

doi:10.1016/b978-0-12-394383-5.00014-x

Cited by 71 publications

(42 citation statements)

References 184 publications

(198 reference statements)

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“…The investigation showed that these extracts did not cause changes in the hydrophobic part of liposome membranes, in the frequency range corresponding to vibrations of the bonds of CH 3 and CH 2 in the hydrocarbon chains of lipid molecules. However, minor shifts in the carbonyl, choline and phosphate bands of DPPC were observed in the absorption IR spectra: smaller for the LB and HB extracts and slightly greater for the WB.…”

Section: Discussionmentioning

confidence: 95%

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Application of the DSC and spectroscopy methods in the analysis of the protective effect of extracts from the blueberry fruit of the genus Vaccinium in relation to the lipid membrane

Pruchnik

Bonarska-Kujawa

Żyłka

et al. 2018

J Therm Anal Calorim

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The aim of the study was to determine changes incurred in lipid model membranes by polyphenol compounds from blueberry fruit of the genus Vaccinium that includes low, high and black blueberry. In particular, the effect of extracts on the packing order in the lipid hydrophilic phase, the fluidity of the hydrophobic phase, as well as the temperature of the phase transition in phospholipids was studied. Model membranes were formed of dipalmitoylphosphatidylcholine (DPPC) and egg phosphatidylcholine. The interaction of extracts with lipids was studied using the differential scanning calorimetry, infrared spectroscopy (ATR-FTIR) and fluorimetry using Laurdan, Prodan and DPH probes. All experimental results indicate that the biggest changes are in the hydrophilic part of the lipid bilayer. The polyphenol compounds had practically no influence on fluidity in the hydrophobic region of the membranes. No changes in the temperature of the main phase transition of DPPC were observed and only a small change in the temperature of pretransition for high concentration of compounds. Results obtained with the ATR-FTIR method did not reveal any changes in the alkyl chain region of bilayer; however, a small shift of bands was observed for phosphate and choline groups-the broadest effect appeared for the wild bilberry. The findings indicate that polyphenolic compounds contained in extracts of blueberries interact with the membrane surface and therefore can protect it.

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Section: Discussionmentioning

confidence: 95%

“…Bilberry, for example, has historically been used as a medicinal herb to treat diarrhea and improve night vision. Analysis of bilberry fruits' composition shows that they are a rich source of nutraceutics like phenolic substances, carotenoids and vitamins [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Application of the DSC and spectroscopy methods in the analysis of the protective effect of extracts from the blueberry fruit of the genus Vaccinium in relation to the lipid membrane

Pruchnik

Bonarska-Kujawa

Żyłka

et al. 2018

J Therm Anal Calorim

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“…APE is a rich source of polyphenols, primarily flavanols, flavan-3-ols, dihydrochalcones and chlorogenic acid 5 . These groups of phytochemicals are well documented for their function as antioxidants, enzyme inhibitors and cell signaling pathway modulators 17 . Many studies have evaluated their antihypertensive effects under in vitro conditions.…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive Effects of Apple Peel Extract on Spontaneously Hypertensive Rats

Balasuriya¹,

Rupasinghe²,

Sweeney³

et al. 2015

Pharmacologia

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Background and Objectives:Apple peel is a rich source of biological active phytochemicals such as flavonoids. The present study investigated the antihypertensive effect of flavonoid-rich Apple Peel Extract (APE) on Spontaneously Hypertensive Rats (SHR). Methodology: Three groups of animals: Control, captopril (20 mg kgG 1 of body weight/day) and APE (25 mg kgG 1 of body weight/day) were fed standard rat chow and their corresponding treatment in sugar-free gelatin, daily for a period of eight weeks. Blood Pressure (BP) was monitored weekly using the tail cuff method. Blood and tissue samples were collected after the eighth week. Results: As expected, treatment with captopril consistently reduced BP (p<0.05). APE treatment reduced both systolic and diastolic BP by 15 and 11 mg Hg, respectively, after 5 weeks of treatment, However, statistical significance was only achieved in systolic BP after eight weeks when compared with control (p<0.05). There were no significant differences in serum and lung ACE activity at week eight. Treatment with APE increased liver superoxide dismutase (SOD) activity by 78% and total reduced Glutathione (GSH) concentrations by 42% when compared to control (p<0.05) but had no effect on the activity of glutathione reductase or peroxidase. Conclusion: Long term intake of APE reduces high blood pressure in SHR possibly through endogenous antioxidant pathways. This preclinical trial suggests that APE as a dietary supplement could be effective in managing early stages of hypertension.

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“…Polyphenols also increase glutathione, and inhibit ROS-producing enzymes such as NOX and XO. These pathways lead to improved endothelial function (Rodrigo et al, 2012). However, some studies have shown increased blood pressure by association of polyphenols with vitamin C (Ward et al, 2005).…”

Section: Polyphenolsmentioning

confidence: 99%

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2015

Exp Clin Endocrinol Diabetes

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Antihypertensive Role of Polyphenols

Cited by 71 publications

References 184 publications

Application of the DSC and spectroscopy methods in the analysis of the protective effect of extracts from the blueberry fruit of the genus Vaccinium in relation to the lipid membrane

Application of the DSC and spectroscopy methods in the analysis of the protective effect of extracts from the blueberry fruit of the genus Vaccinium in relation to the lipid membrane

Antihypertensive Effects of Apple Peel Extract on Spontaneously Hypertensive Rats

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