Antiinflammatory activity of <i>Ipomoea pes‐caprae</i> (L.) R. Br

Pongprayoon, U.; Bohlin, Lars; Soonthornsaratune, P.; Wasuwat, S.

doi:10.1002/ptr.2650050205

Cited by 27 publications

(20 citation statements)

References 8 publications

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“…By comparing the retention times, the selected ion current ( m/z = 51, 77, 107 and 135) profile, and the possible fragmentation mechanisms, we calculated that the structure of compound with retention time of 14.114 min was 4-hydroxy-3-methoxystyrene, which may be derived from decarboxylation of ferulic acid [15,16]. It has been reported to possess anti-inflammatory and anti-oxidative activity [17]. 4-Hydroxy-3-methoxystyrene levels increased with increasing boiling times and approximated the threshold value of 0.3 mg/L after 3 h [15].…”

Section: Resultsmentioning

confidence: 99%

Characterization of the Antibacterial Activity and the Chemical Components of the Volatile Oil of the Leaves of Rubus parvifolius L.

Cai

Huang

et al. 2012

Molecules

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Rubus parvifolius L. (Rp) is a medicinal herb that possesses antibacterial activity. In this study, we extracted the volatile oil from the leaves of Rp to assess its antibacterial activity and analyze its chemical composition. A uniform distribution design was used to optimize the extraction procedure, which yielded 0.36% (w/w) of light yellowish oil from the water extract of Rp leaves. We found that the extracted oil effectively inhibited the growth of a wide range of Gram positive and negative bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumanii, Bacillus cloacae, and Klebsiella pneumoniae. We further analyzed the components contained in the hydro-distillated Rp volatile oil by gas chromatography-mass spectroscopy. Twenty nine compounds were identified, including 4-hydroxy-3-methoxystyrene (66%), 3,7,11,15-tetramethyl-2-hexadecen-1-ol (10%) and 4-tert-butylbenzoic acid (2%). Our results suggest that one or multiple constituents contained in Rp volatile oil may account for its antibacterial activity.

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Section: Resultsmentioning

confidence: 99%

Characterization of the Antibacterial Activity and the Chemical Components of the Volatile Oil of the Leaves of Rubus parvifolius L.

Cai

Huang

et al. 2012

Molecules

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“…Preliminary results of chemical investigation of Ipomoea pes caprae showed that the extract contains phenolic and terpenoid substances (Pongprayoon et al, 1991a). In vitro assay detected 2-hydroxy-4,4,7-trimethyl-1(4H)-naphthalenone, mullein, eugenol and 4-vinylguaiacol isolated from I. pes caprae that had inhibitory effect on the synthesis of prostaglandin (Pongprayoon et al, 1991b).…”

Section: Discussionmentioning

confidence: 97%

Antinociceptive activity of Ipomoea imperati (Vahl) Griseb., Convolvulaceae

Paula-Zurron¹,

Petraglia²,

Aur³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Atividade antinociceptiva de Ipomoea imperati (Vahl) Griseb., Convolvulaceae". A espécie vegetal Ipomoea imperati (Vahl) Griseb., Convolvulaceae, é usada popularmente para tratar inflamação, inchaço e feridas, bem como para tratar dor após o parto e dor estomacal. A administração do extrato etanólico e das frações lipídica e aquosa de I. imperati (300, 100 e 200 mg/ kg) inibiu significativamente as contrações abdominais em camundongo induzidas por ácido acético, aumentou o tempo de sono evocado por pentobarbital sódico e mostrou significativa atividade inibitória sobre o edema de pata de camundongo induzido por formalina. As mesmas doses de I. imperati (300, 100 e 200 mg/kg) também elevou a latência de todos os tempos observados no teste da placa quente. O pré-tratamento de animais com naloxona (5 mg/kg, i.p) sugere a participação do sistema opioide no efeito anti-nociceptivo de Ipomoea imperati.Unitermos: Ipomoea imperati, Convolvulaceae, dor, atividade analgésica, sistema opioide. ABSTRACT:Ipomoea imperati (Vahl) Griseb., Convolvulaceae, is used in folk medicine for the treatment of inflammation, swelling and wounds, as well as to treat pains after childbirth and for stomach problems. Administration of ethanol extract, lipid and aqueous fraction of I. imperati (300, 100 and 200 mg/kg) significantly inhibited the abdominal constriction in mice induced by acetic acid; increased the sleeping time evoked by pentobarbital sodium and showed a significant activity by inhibiting formalin-induced paw edema in mice. The same dose of I. imperati also raised the pain of mice in the hot-plate test and increased the latency at all observation times. The pre-treatment of the animals with naloxone (5 mg/kg, i.p.) suggested the participation of the opioid system in the antinociceptive effect of Ipomoea imperati.

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“…Eugenol is a well-known inhibitor of prostaglandin synthesis and also possesses antiinflammatory activity. Eugenol and guaiacol are also reported to inhibit leukocyte chemotaxis and prevent the production of oxygen free-radicals by leukocytes (Pongprayoon et al, 1991a). Others chemical studies related that I. pes-caprae contains phenolic and terpenoid substances that must to assure the antioxidative activity (Pongprayoon et al, 1991b).…”

Section: Discussionmentioning

confidence: 99%

Anti-oxidative and anti-ulcerogenic activity of Ipomoea imperati

Miyahara¹,

Imamura²,

Freitas

et al. 2011

Rev. bras. farmacogn.

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Abstract:Ipomoea imperati (Vahl) Griseb., Convolvulaceae, is used in traditional medicine for the treatment of inflammation, swelling and wounds, as well as to treat pains and stomach problems. This work evaluates the anti-oxidative activity by ESR (Electron Spin Resonance spectroscopy) and the preventive and curative actions of I. imperati in gastric ulcer animal model. Ipomoea imperati (200 mg/kg, p.o.) prevented the formation of gastric lesions in 78% (p<0.05) when compared with the negative control tween 80. Lanzoprazole, prevented in 85% the gastric lesions formation induced by ethanol (p<0.05). Therefore, the oral administration of I. imperati one hour before the ulcerogenic agent prevented the ulcer formation, conserving the citoprotection characteristics of the gastric mucosa and assuring the integrity of gastric glands and gastric fossets. The healing activity of I. imperati (200 mg/kg, p.o.) evaluated in chronic ulcer experiments induced by the acetic acid, was 72% (p<0.05). The positive control, ranitidine, healed 78% of the gastric lesions (p<0.05). The histological analysis confirmed the recovery of the mucosal layer and the muscle mucosal layer harmed by the acetic acid. Experiments in vitro with DPPH (2.2-diphenyl-1-picrylhydrazyl) of anti-oxidative activity demonstrated that I. imperati presents an IC50 of 0.73±0.01 mg/mL.

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Antiinflammatory activity of Ipomoea pes‐caprae (L.) R. Br

Cited by 27 publications

References 8 publications

Characterization of the Antibacterial Activity and the Chemical Components of the Volatile Oil of the Leaves of Rubus parvifolius L.

Characterization of the Antibacterial Activity and the Chemical Components of the Volatile Oil of the Leaves of Rubus parvifolius L.

Antinociceptive activity of Ipomoea imperati (Vahl) Griseb., Convolvulaceae

Anti-oxidative and anti-ulcerogenic activity of Ipomoea imperati

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