Antiinflammatory activity of Phyllanthus emblica, Plumbago zeylanica and Cyperus rotundus in acute models of inflammation

Abstract

Experimental studies conducted earlier have proved that Phyllanthus emblica (Pe), Plumbago zeylanica (Pz) and Cyperus rotundus (Cr), plants from the medohara group of Ayurveda possess antiatherosclerotic activity. As inflammation is also one of the pathophysiological factors, it was of interest to evaluate whether these drugs exhibit any antiinflammatory activity. Two models of acute inflammation, namely carrageenan induced rat paw edema and acetic acid induced peritonitis in mice were used. In the model of carrageenan induced paw edema Pe, Pz and Cr showed a trend to reduce the edema while the combination of Pe + Pz (PI: 20.64%) showed results comparable to aspirin (23.74%). Whereas in a model of acetic acid induced peritonitis, all the plant drugs i.e. Pe, Pz, Cr and a combination of Pe + Pz showed a significant decrease in the protein content of the peritoneal exudates compared with the disease control group (p < 0.05), however, only Pe + Pz exhibited activity comparable to aspirin.

A review on Cyperus rotundus A potential medicinal plant

“…In the model of carrageenan induced paw edema Cyperus rotundus showed a trend to reduce the edema, whereas in a model of acetic acid induced peritonitis, Cyperus rotundus induced significant decrease in the protein content of the peritoneal exudates compared with the disease control group (p < 0.05) [99]. Clinical studies with 2% aqueous extract of Cyperus rotundus showed anti-inflammatory activity in conjunctivitis in human [100].…”

Total Phenolic Content and Free Radical Scavenging Activity of Representative Medicinal Plants of Thailand

“…have been reported for its antioxidant, antipyretic, antimicrobial, anticancer, anti-inflammatory, immunomodulatory, hypolipidemic, and hepatoprotective properties [20][21][22][23][24][25][26][27]. The methanolic extract of P. emblica has been reported for the bacterial efflux pump inhibiting activity [28].…”

Evaluation of gastric motility of Phyllanthus emblica and Asparagus racemosus in cold stress induced gastric damage

“…1 P. emblica has been shown to possess anti-inflammatory effects. 2,3 As the current anti-inflammatory agents are known to possess GI related adverse effects, agents which have gastro protective effects are required. In a study published by Bandyopadhyay SK and Shirish SS et al Phyllanthus emblica has shown to have protective effect on gastric ulcer.…”