Antiinflammatory activity of the methanolic extract of the seeds of Carica papaya in experimental animals

“…Papaya seeds (methanol and aqueous extract) have also been examined and found to display anti-inflammatory activity in in vivo study (Amazu et al 2010;Umana et al 2014). However, their activity toward immune-inflammatory markers (such as those in in vitro studies) in vivo has not been reported to date.…”

Section: Cd127mentioning

confidence: 99%

Anti-inflammatory and immunomodulatory properties of Carica papaya

Pandey

Cabot

Shaw

et al. 2016

Journal of Immunotoxicology

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Chronic inflammation is linked with the generation and progression of various diseases such as cancer, diabetes and atherosclerosis, and anti-inflammatory drugs therefore have the potential to assist in the treatment of these conditions. Carica papaya is a tropical plant that is traditionally used in the treatment of various ailments including inflammatory conditions. A literature search was conducted by using the keywords ''papaya'', ''anti-inflammatory and inflammation'' and ''immunomodulation and immune'' along with cross-referencing. Both in vitro and in vivo investigation studies were included. This is a review of all studies published since 2000 on the antiinflammatory activity of papaya extracts and their effects on various immune-inflammatory mediators. Studies on the anti-inflammatory activities of recognized phytochemicals present in papaya are also included. Although in vitro and in vivo studies have shown that papaya extracts and papaya-associated phytochemicals possess anti-inflammatory and immunomodulatory properties, clinical studies are lacking. ARTICLE HISTORY

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“…Gout is a clinical metabolic disorder of xanthine oxidase, which is associated albumin denaturation in a dose-dependent manner with C. papaya giving a comparable activity to the positive control at 0.25 -1 µg/ml and significantly higher effect at 0.0625-0.125 µg/ml (Table 6). Papaya seed extracts (methanol and aqueous) have also been reported for antiinflammatory activities in in vivo studies (Rahmani and Aldebisi, 2016;Amazu et al, 2010;Umana et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Anti-hyperglycaemic, anti-inflammatory and anti-oxidant activities of <i>Carica papaya</i> and <i>Citrullus lanatus</i> seeds

Feyisayo¹,

Ayoola²

2018

Ife Journal of Science

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Citrullus lanatusextracts (100, 200 and 400 mg/kg, orally) on a-amylase and a-glucosidase were assessed in glucose and sucrose-induced hyperglycaemic rats using glimepiride (25 mg/kg) and acarbose (50 mg/kg), as positive controls. membrane stability, xanthine oxidase inhibition and inhibition of denaturation of albumin models. Their antioxidant potentials were determined using standard methods and theirThe extracts gave a comparable (p>0.05) hyperglycaemia lowering and a-glucosidase inhibitory activities to glimepiride (25 mg/kg) and acarbose (50 mg/kg), respectively. However, C. papaya gave a significantly (p<0.05) higher a-amylase inhibitory activity than C. lanatus at all concentrations. The seed extract of C. papaya was significantly more active in red blood cell membrane stabilizing activity at all concentrations than C. lanatus and ibuprofen while their order of xanthine oxidase inhibitory activities was: allopurinol > C. papaya > C. lanatus. In albumin denaturation assay, C. papaya gave a comparable activity to the positive control at 0.25 -1.00 µg/ml and significantly higher effect at 0.0625-0.125 µg/ml while in the 1, 1, diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, total antioxidant capacity (TAC) and ferric reducing antioxidant power (FRAP) assays, the order of antioxidant activities was, ascorbic acid (positive control) > C. papaya > C. lanatus. The total phenolic and flavonoid contents of C. papaya expressed as gallic acid and quercetin equivalents were found to be 82.00 and 35.00 mg/g respectively; while those of C. lanatus were 40.00 and 20.00 mg/g, respectively. The results showed the seed extract of C. papaya to be a better anti-hyperglycaemic, antiinflammatory and antioxidant agent than C. lanatus and suggested that their high flavonoid and phenolic contents could be responsible for these activities. ABSTRACTThe study investigated the anti-hyperglycaemic, anti-inflammatory and antioxidant potentials of methanolic seed extracts of Carica papaya and . The inhibitory effects of the The anti-inflammatory activities were evaluated by total phenolic and flavonoid contents were also estimated. 207

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Antiinflammatory activity of the methanolic extract of the seeds of Carica papaya in experimental animals

Cited by 51 publications

References 5 publications

A survey of folk remedies for gastrointestinal tract diseases from Thailand's three southern border provinces

A survey of folk remedies for gastrointestinal tract diseases from Thailand's three southern border provinces

Anti-inflammatory and immunomodulatory properties of Carica papaya

Anti-hyperglycaemic, anti-inflammatory and anti-oxidant activities of <i>Carica papaya</i> and <i>Citrullus lanatus</i> seeds

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