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The antimicrobial effect of the leaf extract and fractions of Lupinus arboreus was investigated. The crude methanol extract (CME) of the dried leaves obtained by 48 h cold maceration was fractionated into n-hexane fraction (HEF), ethyl acetate fraction (EAF), and methanol fraction (MEF); and evaluated using modified agar-well diffusion method. The results showed that the extract and fractions at varying concentrations, exerted strong antimicrobial activity on some of the test organisms. However, a weak activity was observed on the tested fungi-Aspergillus niger and Candida albicans. Ethyl acetate fraction showed the highest activity on many organisms than extract and other fractions.

Objective: Solenostemon monostachyus P. Beauv (family Lamiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer activity. Materials and Methods: The effects of extract of Solenostemon monostachyus (75 - 225 mg/kg) and fractions (Aqueous and chloroform, 150 mg/kg) on experimentally induced ulcer were studied in rats using ethanol, indomethacin, reserpine and histamine –induced ulcer models. Results: The effect of ethanol extract of S. monostachyus (75 – 225 mg/kg) and fractions on experimentally induced ulcer were studied in rats. The extract (75 – 225 mg/kg) inhibited ethanol, indomethacin and histamine –induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.05, 0.01, 0.001). The effect of the extract was comparable to that of the standard drugs used with the dichloromethane fraction having the highest activity. Conclusion: Thus, S. monostachyus extract demonstrated a good antiulcer activity which supports the use of this plant in the traditional medicine to treat ulcers.

This study assessed the comparatively antimicrobial activity of ethanol extracts of aeruginosa, respectively at the same concentration (100 mg/mL). S. aureus showed greatest susceptibility while P. aeruginosa was the least for both extracts. The stem bark extract of C.Africana possess greater antimicrobial activity compared to B. dalzielii.