Antiulcerogenic activity of Solenostemon monostachyus

Amazu, Louis U; Antia, Bassey S.; Okokon, Jude E.

doi:10.31254/phyto.2015.4207

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…The gastroprotective effect exhibited by H. annuus may be attributed to the presence of flavonoids and polypheolic compounds, saponins and tannins. 33,34 These compounds most likely inhibit gastric mucosal injury by scavenging the stress-generated oxygen metabolites. 35 Flavonoids have been reported possess protective effects on gastric mucosa and a variety of ulcerogenic agents in different mammalian species.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the antiulcer and antimicrobial activities of methanol leaf extract of Helianthus annuus

Ajegi

Ajegi²,

Ajaegbu³

et al. 2023

Int J Basic Clin Pharmacol

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Background: Medicinal plants are widely used in treating and preventing specific diseases and are known to play an important role in health care. Helianthus annuus is one of such plants whose therapeutic applications no doubt have numerous folkloric background. This study aimed at assessing Helianthus annuus methanol leaf extract for antiulcer and antimicrobial potentials Methods: The antiulcer activity was evaluated using aspirin, ethanol and histamine methods in Wistar rats, while the antimicrobial activity was carried out on selected microorganisms. The acute toxicity test and phytochemical screening of the extract were also conducted. Results: The methanol leaf extract exhibited significant (p<0.05 and p<0.01) antiulcer effect in both model. The ulcer protection effect of the extract is comparable to omeprazole. The extract also significantly inhibited the growth of test organisms. The acute toxicity test produced no lethality in rats, whereas the phytochemical analysis revealed the presence of alkaloids, saponins, tannins, flavonoids, terpenoids and steroids. Conclusions: The findings confirm the ethnomedicinal use of H. annuus leaf as a valuable natural agent for the treatment of ulcer and microbial infections.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the antiulcer and antimicrobial activities of methanol leaf extract of Helianthus annuus

Ajegi

Ajegi²,

Ajaegbu³

et al. 2023

Int J Basic Clin Pharmacol

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“…The essential oil obtained from Solenostemon monostachyus leaf contains βpinene, oct-1-en-3-ol, β-caryophyllene, octan-3ol and (E,E)-α-farnesene [15]. Reported biological activities of the plant include antioxidant and antihypertensive, antimicrobial activities and antiulcer [17]. Peperomia pellucida (L.), known commonly as silver bush or shiny bush is of the family Piperaceae.…”

Section: Solenostemon Monostachyus P Beauv Of the Lamiaceae Family Co...mentioning

confidence: 99%

Evaluation of Antimicrobial Activities of Medicinal Plants Used against Microbial Infections in Pregnant Women in Delta State, Nigeria

Adomi,

Idundun

2023

JAMB

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Pregnant women are important people in society. As such, their health condition is paramount. Healthy babies reflect the health condition of fetus in the womb and the mother. In Nigeria, pregnant women consult local midwives for the purpose of their health and that of their unborn children. Medicinal plant ingestion is common among pregnant women as they believe it is safe and effective for curing ailment and maintaining good health. Microbial diseases that infect pregnant women are numerous. There is therefore a need to detect other bioactive compounds which could be used for treating and maintaining good health in pregnant women. The study was designed to evaluate the antimicrobial activities of medicinal plants used for pregnancy care. Medicinal plants used were identified by oral interview. Microorganisms were isolated and identified by standard methods from urine samples. Result from oral interviewers showed that some medicinal plants and substances including kaolin clay were used by pregnant women. Microrganisms identified were Pseudomonas aeruginosa, Staphylococcus aureus, and others including Candida albicans. Ficus exasperata and Solenostemon monostachyus were active against Candida albicans at 12.5mg/ml but not active on any bacteria. Peperomia pellucida had no inhibitory effect on any of the microorganism. In conclusion, Ficus exasperata and Solenostemon monostachyus could be used to treat microbial infections caused by Candida ablicans during pregnancy.

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“…Hence, could be one of the possible mechanisms through which A. Senegalensis significantly halted ethanol gastric lesions. The protective effect of the extract could be attributed to suppression of lipoxygenase activity (Amazu et al, 2015). Furthermore, it has been recorded that ethanol induced ulcers are not only inhibited by anti-secretory agents like ranitidine, but also agents that promote mucosal defensive factors (Essien et al, 2016).…”

Section: Gastroprotective Potentials Of Annona Senegalensis Ethanol L...mentioning

confidence: 99%

Gastroprotective potential of Annona senegalensis ethanol leaf extract in Wistar rats

Megwas,

Christian Akuodor,

Clinton Chukwu

et al. 2022

JBS

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The leaves of Annona senegalensis are traditionally used for the treatment of different diseases in Nigeria, including gastrointestinal disorders. The anti-diarrheal and ulcer-protective activities of its ethanol extract were determined in Wistar rats. This extract was investigated for castor oil-induced diarrhoea, intestinal transit time and castor oil-induced enteropooling in rats. The leaf extract was also tested for its ulcer protective potentials in acetylsalicylic acid, ethanol and stress-induced ulceration in rats. The phytoconstituents and oral acute toxicity of the leaf extract were also assessed. The extract significantly reduced the frequency of faecal dropping in castor oil-induced diarrhoea. It also inhibited the masses and volumes of intestinal accumulation in castor oil-induced enterpolling in rats. The distance travelled by charcoal meal was as well reduced. The phytochemical tests revealed the presence of alkaloids, saponins, tannins, flavonoids, terpenoids, and anthraquinone. However, the LD50 was greater than 5000 mg/kg in rats. The ethanol leaf extract of A. senegalensis exhibited strong antidiarrheal and ulcer protective activities, thus justifying its folkloric use by the local population against gastrointestinal disorders.

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Antiulcerogenic activity of Solenostemon monostachyus

Cited by 6 publications

References 23 publications

Evaluation of the antiulcer and antimicrobial activities of methanol leaf extract of Helianthus annuus

Evaluation of the antiulcer and antimicrobial activities of methanol leaf extract of Helianthus annuus

Evaluation of Antimicrobial Activities of Medicinal Plants Used against Microbial Infections in Pregnant Women in Delta State, Nigeria

Gastroprotective potential of Annona senegalensis ethanol leaf extract in Wistar rats

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