Antiinflammatory and Antinociceptive Activities of <i>Zingiber zerumbet </i>Methanol Extract in Experimental Model Systems

Abstract

Objective: The present study was carried out to determine the antiinflammatory and antinociceptive activities of a methanol extract of Zingiber zerumbet rhizomes (MEZZ) using various experimental model systems. Materials and Methods: The MEZZ was prepared by macerating oven-dried (50°C) powdered rhizomes (1.2 kg) of Z. zerumbet in 80% methanol in a ratio of 1:20 (w/v) for 48 h. The supernatant was collected, filtered and evaporated to dryness under reduced pressure (50°C) yielding approximately 21.0 g of the crude dried extract. The crude dried extract was stored at –20°C prior to use and was dissolved in normal saline (0.9% NaCl) immediately before administration at concentrations required to produce doses of 25, 50 and 100 mg/kg. Results: All dosages of MEZZ showed significant (p < 0.05) antiedema activity when assessed using the carrageenan-induced paw edema test and the cotton-pellet-induced granuloma test. The MEZZ exhibited significant (p < 0.05) antinociceptive activity when assessed by the writhing, hot plate and formalin tests. Pretreatment with naloxone (5 mg/kg) significantly decreased the latency of discomfort produced by the 100 mg/kg dose of MEZZ in the hot plate test. Conclusion: MEZZ produced antiinflammatory and antinociceptive activities which may involve the inhibition of bradykinin-, prostaglandin-, histamine- and opioid-mediated processes.

Bioassay of Eucalyptus extracts for anticancer activity against Ehrlich ascites carcinoma (eac) cells in Swiss albino mice

“…More than 250 plants are being used for the treatment of various diseases. However, few of these plants have undergone chemical, pharmacological and toxicological studies [1][2][3][4] . In order to get anticancer agents from natural sources, we have primarily selected four plants [namely Feronia limonia (F. limonia), Azadirachta indica (A. indica), Costus curvibracteatus (C. curvibracteatus) and Eucalyptus camaldulensis (E. camaldulensis )] which are well known to possess therapeutic values in the Ayurvedic and Unani pharmacopoeia.…”

Cytotoxicity of the rhizome of medicinal plants

“…Several of these substances are believed to have potential value as cancer chemopreventive or therapeutic agents [1] . Moreover, from the ancient time, many plants are used as folk medicines to treat infectious diseases such as urinary tract infections, diarrhea, cutaneous abscesses, bronchitis and parasitic diseases [2][3][4][5] .…”

“…Z. zerumbet (L) Smith. is commonly known as the pinecone or shampoo ginger and also known by various names for example, "Bon adha" (Bangladesh), "Ghatian" and "Yaiimu" (India), "Lempoyang" (Malaysia and Indonesia), "Awapuhi" (Hawaii), "Zurunbah" (Arab), "Hong qiu jiang"(China) and "Haeo dam" or "Hiao dam" (Northern Thailand) [3,4,6,9] , whereas C. zedoaria Rosc. is known as white turmeric, zedoaria or gajutsu, but in Bangladesh it is known as "Shoti" [10,11] .…”

“…The rhizomes of Z. zerumbet (L) Smith. are used in the traditional medicine as a cure for swelling, loss of appetite, lumbago, diabetes, inflammation, chest pain, rheumatic pains, bronchitis, dyspepsia and sore throat [3,4,6,14] . The rhizome of C. zedoaria Rosc.…”

“…The juice of the boiled rhizomes of both plants has also been used in indigenous medicine for worm infestation in children [16,17] . From the pharmacological point of view, Z. zerumbet has been reported to have antimicrobial [8] , anti-inflammatory [4] , antinociceptive [18] , antiallergic [19] , antioxidant [20] , antiplatelet aggregation [21] , anthelmintic [22] and antihypertensive activities [23] . The rhizome of C. zedoaria Rosc.…”