Antiinflammatory and Antioxidant Effects of Aqueous Extract from Phellinus gilvus in Rats

Abstract

This study evaluated the antiinflammatory activities of an aqueous extract of Phellinus gilvus (PG) against carrageenan-and cotton pellet-induced acute and chronic inflammation in rats. Four acute and chronic inflammation groups included the vehicle control group, positive control group (aminopyrine, 100 mg/kg), PG10 group (PG, 10 mg/kg), and PG20 group (PG, 20 mg/kg). Oral administration of PG extract produced dose-dependent antiinflammatory effects in both the acute and chronic groups. In the carrageenan-induced paw edema, significant inhibitions were observed at 0.5 and 1 hr in the PG10 group and at 0.5, 1, 2, 4, 5, and 6 hr in the PG20 group. In the cotton pellet-induced granuolma formation, PG extract at 10 and 20 mg/kg per day also showed significant inhibition in the wet and dry weights of granuloma. The free radical scavenging assay indicated a dose-dependent scavenging activity of PG against 2,2-diphenyl-1-picrylhydrazyl free radicals. PG extract may be beneficial as an antiinflammatory agent by virtue of antioxidant action.

Second metabolite content and antioxidative, α-amylase inhibitory activity of Phellinus gilvus fruiting body extracts

“…At concentration of 1.6 mg/mL, the inhibitory percentage of n-Hexane fraction only reached 27.01%. A previous report showed similar result, DPPH radical scavenging activity of water fraction of P. gilvus collected in Korea was 55% at concentration of 0.1 mg/mL [29]. However, another report showed that ethyl acetate fraction of P. gilvus isolated in Korea had highest DPPH radical scavenging activity with IC50 value of 13.34 μg/mL (scavenging 70.38% of DPPH radical).…”

Antiproliferative agents from mushroom phellinus sp.

“…The crude aqueous fruiting body extract of Phellinus showed anti-inflammation activity (IC 50 =19.46 µg/mL) on RAW 264.7 cells [48]. Furthermore, the ethanolic extract give 3,4-dihydroxybenzal-acetone (26) test with in acute lung injury (ICR mice) [29], igniaren B (35), igniaren D ( 36) and ergosta-6,22-die3 β -ol (37) exhibited anti-inflammatory activity test on RAW 264.7 cells with IC 50 values 5 mg/Kg mouse (In vivo), 47.89, 91.74 and 37.57 µg/mL, respectively [27,28] showed in Table 3.…”

“…Phytochemical compound of genus Phellinus has been reported to be rich sources of biological activities, reported that polysaccharides, flavones, coumarins, terpenes, steroids and styrylpyranones [8]. These compounds exhibit different bioactivities, such as anticancer [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26], anti-inflammatory [27][28][29][30], antidiabetic [31], antioxidant [10,11,18,23,[32][33][34][35], antimicrobial [36][37][38][39][40][41][42][43] and hepatoprotective [11,37].…”

“…The methanolic extract of Phellinus mushroom from fruiting body was evaluated rat lens aldose reductase (RLAR) and human recombinant aldose reductase (HRAR). They were identified as phelligridimer A (27), protocatechualdehyde (28), ellagic acid (29), inoscavin A (10), davallialactone (30), methyl davallialactone (31), hispidin (11), caffeic acid (32), interfungin A (33) and hypolomine B (34). Moreover, davallialactone (30) exhibited strong RLAR and HRAR inhibitory activity with IC 50 values 0.33 and 0.56 µM, respectively [47] showed in Table 2.…”