“…The majority of reports of severe reactions show a marked relation to the total dosage administered. The remainder of these reactions appear to be due to individual hypersensitivity, which is apparently unrelated to previous drug exposure, and is not enhanced after a subsequent administration (Dvorak and Blaszkova, 1965;Meiers, Gehrmann, and Gahlen, 1963). Such reactions have not been observed by the authors in a 10-year period, during which more than 200 gouty patients have been treated with this drug.…”