1963
DOI: 10.1055/s-0028-1111984
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Antikörperbedingte thrombozytopenische Purpura nach Phenylbutazon*

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1963
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Cited by 13 publications
(2 citation statements)
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“…The majority of reports of severe reactions show a marked relation to the total dosage administered. The remainder of these reactions appear to be due to individual hypersensitivity, which is apparently unrelated to previous drug exposure, and is not enhanced after a subsequent administration (Dvorak and Blaszkova, 1965;Meiers, Gehrmann, and Gahlen, 1963). Such reactions have not been observed by the authors in a 10-year period, during which more than 200 gouty patients have been treated with this drug.…”
mentioning
confidence: 92%
“…The majority of reports of severe reactions show a marked relation to the total dosage administered. The remainder of these reactions appear to be due to individual hypersensitivity, which is apparently unrelated to previous drug exposure, and is not enhanced after a subsequent administration (Dvorak and Blaszkova, 1965;Meiers, Gehrmann, and Gahlen, 1963). Such reactions have not been observed by the authors in a 10-year period, during which more than 200 gouty patients have been treated with this drug.…”
mentioning
confidence: 92%
“…A similar mechanism is probably responsible for the amidopyrine-induced agranulocytosis in which we again deal with individual hypersensitivity. According to Meiers, Gehrmann, and Gahlen, 1963), antibodies have also been found in a patient with a blood disorder due to phenylbutazone. As far as we know the mechanism responsible for the blood dyscrasias associated with the other drugs in Table I has not been established.…”
mentioning
confidence: 99%