2019
DOI: 10.1016/j.ejmech.2018.10.065
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Antileishmanial activity of new hybrid tetrahydroquinoline and quinoline derivatives with phosphorus substituents

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Cited by 45 publications
(32 citation statements)
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“…In contrast, the microwave procedure showed the highest products yields (67-72%) within 30 min of reaction at 160 • C. As a second reaction step, the microwave methodology allowed us to produce the propargyl derivatives in an efficient and environmentally friendly approach. The reaction conditions optimization involved the modification of the heating source [90,91]. The reaction conditions optimization involved the modification of the heating source [90,91].…”
Section: Synthesis Of N-propargylanilinesmentioning
confidence: 99%
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“…In contrast, the microwave procedure showed the highest products yields (67-72%) within 30 min of reaction at 160 • C. As a second reaction step, the microwave methodology allowed us to produce the propargyl derivatives in an efficient and environmentally friendly approach. The reaction conditions optimization involved the modification of the heating source [90,91]. The reaction conditions optimization involved the modification of the heating source [90,91].…”
Section: Synthesis Of N-propargylanilinesmentioning
confidence: 99%
“…The reaction conditions optimization involved the modification of the heating source [90,91]. The reaction conditions optimization involved the modification of the heating source [90,91]. Thus, the total reaction time was reduced from 96 h to 15 min (Table 4) through microwave-assisted methodology and compound yields were 2.5-fold increase in comparison with conventional procedures.…”
Section: Synthesis Of N-propargylanilinesmentioning
confidence: 99%
“…Hybrids of 2‐ and 4‐disubstituted quinoline scaffolds with phosphorus substituents at 8‐position were designed and synthesized [33] . The phosphorylated hybrid molecules were checked for their leishmanial inhibitory properties.…”
Section: Antileishmanial Activitymentioning
confidence: 99%
“…Demonstration of quinoline derivatives with good antileishmanial activity. [31][32][33] Figure 10. Structures of hybrid-quinoline derivatives with antileishmanial potencies.…”
Section: Antileishmanial Activitymentioning
confidence: 99%
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