Antileishmanial anthraquinones from the rhyzomes of Rumex abyssinicus Jacq (Polygonaceae)

Abstract

Phytochemical investigation of the rhyzomes of Rumex abyssinicus (Polygonaceae) afforded six anthraquinones viz chrysophanol (1), physcion (2), emodin (3), mixture of physcion-8-Oβ,D-glucopyranoside (4) and chrypsophanol-8-O-β,D-glucopyranoside (5), and emodin-8-Oβ,D-glucopyranoside (6). All the compounds were characterised and identified by comparison of their MS and NMR data with available literature data. The isolated compounds were evaluated for their antileishmanial activity. Emodin (3) was the most active compounds with IC 50 13.82 and 0.26 µg/mL against Leishmania donovani amastigotes and promastigotes, respectively. Emodin-8-O-β,D-glucopyranoside (6) also showed a moderate activity with IC 50 27.53 and 37.08 µg/mL. This is the first report of antileishmanial compounds from R. abyssinicus and the antileishmanial activities of compounds 2, 4, 5 and 6 are here reported for the first time.

A study of the protease inhibitory activity component of SARS-CoV-2 3CL in Bletilla striata

“…ESI-MS m/z 285.07 [M + H] + . Compound 3 was tentatively identified as Physcion (Guetchueng et al, 2023).…”

Penicillium janthinellum: A Potential Producer of Natural Products

“…Furthermore, compound 29 inhibited the proliferation of human mesangial cells with an IC 50 value of 17.9 ± 1.2 µM [52]. Moreover, compound 29 exhibited significant antileishmanial activity against Leishmania donovani amastigotes and promastigotes with IC 50 values of 13.82 and 0.26 µg/mL, respectively [53]. This compound was also able to inhibit ERα transcriptional activation to reduce ERα protein levels, resulting in the suppression of breast cancer cell proliferation [54].…”

“…Four novel azaphilones, penicilones A-D (48-51), were isolated from a mangrove rhizosphere soil-derived fungus P. janthinellum HK1-6 in 2017 [87]; then, the fungus was cultivated using NaBr as an alternative to NaCl, resulting in the isolation of two new polyketides, penicilones G (52) and H (53), from the fungus HK1-6 in 2019 [88,89]. Compounds 49-51 showed potent antibacterial activities against two strains of methicillin-resistant S. aureus ATCC 43300S and ATCC 33591 with MIC values from 3.13 to 6.25 µg/mL and two strains of susceptible S. aureus ATCC 25923 and ATCC 29213 with MIC values from 3.13 to 12.5 µg/mL.…”