Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311

Ortega, Humberto E.; Lourenzon, Vitor B.; Chevrette, Marc G.; Ferreira, Leonardo L. G.; Alvarenga, René F. Ramos; Melo, Weilan Gomes da Paixão; Venâncio, Tiago; Currie, Cameron R.; Andricopulo, Adriano D.; Bugni, Tim S.; Pupo, Mônica Tallarico

doi:10.1016/j.bmc.2021.116016

Cited by 18 publications

(14 citation statements)

References 45 publications

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“…ISID311 (1L of culture) by purifying the crude extract (2.3 g) after a partition of ethyl acetate and water. First, an SPE-C18 clean-up (55 μm, 20 g) was used, and then a semipreparative HPLC with a C18 semipreparative column and gradient of MeOH and H 2 O (0.1% of acetic acid) was used to yield 14.2 mg of caniferolide C [ 182 ].…”

Section: Isolation Of High-value Molecules With Neuroprotective Effects Against Alzheimer’s Diseasementioning

confidence: 99%

“…Parallelly, caniferolide A modulates the state of the microglial cell towards the phenotype of neuroprotection by causing the blockade of the kinases NFKR, p38, and JNK MAPK. This macrolide was also able to decrease the phosphorylation of the tau protein by inhibiting the p38 and JNK kinases, and through the translocation of Nrf2 to the nucleus, it acts as an indirect antioxidant [ 25 , 182 ]. This compound is also capable of inhibiting the BACE-1 enzyme, which participates in the processing of amyloid-beta.…”

Section: Remarks and Future Perspectivesmentioning

confidence: 99%

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Exploitation of Marine Molecules to Manage Alzheimer’s Disease

2021

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Neurodegenerative diseases are sociosanitary challenges of today, as a result of increased average life expectancy, with Alzheimer’s disease being one of the most prevalent. This pathology is characterized by brain impairment linked to a neurodegenerative process culminating in cognitive decline and behavioral disorders. Though the etiology of this pathology is still unknown, it is usually associated with the appearance of senile plaques and neurofibrillary tangles. The most used prophylaxis relies on anticholinesterase drugs and NMDA receptor antagonists, whose main action is to relieve symptoms and not to treat or prevent the disease. Currently, the scientific community is gathering efforts to disclose new natural compounds effective against Alzheimer’s disease and other neurodegenerative pathologies. Marine natural products have been shown to be promising candidates, and some have been proven to exert a high neuroprotection effect, constituting a large reservoir of potential drugs and nutraceutical agents. The present article attempts to describe the processes of extraction and isolation of bioactive compounds derived from sponges, algae, marine bacteria, invertebrates, crustaceans, and tunicates as drug candidates against AD, with a focus on the success of pharmacological activity in the process of finding new and effective drug compounds.

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Section: Isolation Of High-value Molecules With Neuroprotective Effects Against Alzheimer’s Diseasementioning

confidence: 99%

Section: Remarks and Future Perspectivesmentioning

confidence: 99%

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

2021

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“…the ants use bacterial symbionts (typically Actinobacteria belonging to Pseudonocardia [ 79 , 80 ], Streptomyces [ 81 , 82 ] or Saccharopolyspora [ 83 ], but also β-proteobacterial symbionts like Burkholderia [ 84 ]) that produce antifungal compounds that inhibit the invasion by the parasitic fungus [ 85 , 86 ]. Since the identification of the first of those antifungals, the depsipeptide dentigerumycin [ 87 ] ( Figure 4 ), many other novel compounds have been isolated from bacteria associated with fungus-growing ants, like the halogenated NRPS-PKS hybrids colibrimycins [ 88 ] and collismycins [ 89 ] ( Figure 4 ), novel quinones [ 90 ], diverse macrolides showing both antifungal and antileishmanial activities [ 91 ] or the non-ribosomal peptide attinimicin, an iron-dependent antifungal [ 92 ]. Formicamycins ( Figure 4 ), pentacyclic type II PKS products from Streptomyces formicae (a strain isolated from the tree-associated Tetraponera ants which shows an impressive secondary metabolism potential [ 93 ]), show potent activity against Gram-positive pathogens without apparent generation of spontaneous resistance [ 94 , 95 , 96 , 97 ].…”

Section: Insect-associated Bacteriamentioning

confidence: 99%

Beyond Soil-Dwelling Actinobacteria: Fantastic Antibiotics and Where to Find Them

Santos‐Aberturas

Vior

2022

Antibiotics

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Bacterial secondary metabolites represent an invaluable source of bioactive molecules for the pharmaceutical and agrochemical industries. Although screening campaigns for the discovery of new compounds have traditionally been strongly biased towards the study of soil-dwelling Actinobacteria, the current antibiotic resistance and discovery crisis has brought a considerable amount of attention to the study of previously neglected bacterial sources of secondary metabolites. The development and application of new screening, sequencing, genetic manipulation, cultivation and bioinformatic techniques have revealed several other groups of bacteria as producers of striking chemical novelty. Biosynthetic machineries evolved from independent taxonomic origins and under completely different ecological requirements and selective pressures are responsible for these structural innovations. In this review, we summarize the most important discoveries related to secondary metabolites from alternative bacterial sources, trying to provide the reader with a broad perspective on how technical novelties have facilitated the access to the bacterial metabolic dark matter.

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“…ISID311, a bacterial symbiont related with the fungus-growing ant known as Cyphomyrmex sp. These compounds showed high antiprotozoal activity against intracellular amastigotes of Leishmania donovani (a human parasite) recording IC 50 values of 2.32, 0.091 and 0.073 μM, respectively, and high selectivity indexes [ 66 ].…”

Section: Marine Actinomycetes As Sources For Antileishmanial Drugsmentioning

confidence: 99%

Bioprospecting marine actinomycetes for antileishmanial drugs: current perspectives and future prospects

Davies-Bolorunduro

Osuolale

Saibu

et al. 2021

Heliyon

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311

Cited by 18 publications

References 45 publications

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Beyond Soil-Dwelling Actinobacteria: Fantastic Antibiotics and Where to Find Them

Bioprospecting marine actinomycetes for antileishmanial drugs: current perspectives and future prospects

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