Antilipemic Activity of an Extract of Hog Gastric Mucosa

Abstract

In recent years numerous studies have been made on the clearing effect exerted by heparin on hyperlipemic plasma, specially in connection with the problem of atherogenesis. The present paper deals with investigations, carried out on both animals and men, concerning the hypoeholesteremic, plasma-clearing, and lipotropie effects, as well as the inhibitory action on the electrocardiographs changes associated with alimentary hyperlipemia, exerted by orally active extracts of gastric juice and hog gastric mucosa.

The Quantitative Inhibition of Triton Lipemia with Heparin in Rats

“…Triton possibly prevents the activation of the clearing factor by inhibiting the liberation of the heparin, especially from the mucosal mast cells of the gastrointestinal canal. Polysaccharides which reduce the cholesterol level of blood in man, activate the clearing factor and inhibit the clinical symptoms of lipemia, have been isolated from human gastric juice and from hog gastric mucosa (Cantone, Rulli and Rossi 1959). Heparin-like substance (Smith and Gallop 1953) and heparin-synthetising enzyme (Dutton and Stevenson 1959) have been isolated from the dog stomach.…”

The Role of Gastric Mucosal Mast Cells during Triton WR‐1349 Lipemia of Rats

“…The dog's gastric mucosa contains heparin (Bianchini 1958, Smith andGallop 1953), and the microsome fraction of its homogenate contains glucuronyl-transferring enzyme in abundance (Dutton and Stevenson 1959). Extract from the gastric mucosa has been found to possess antilipaemic effect (Cantone, Rulli and Rossi 1959). The optical density of the plasma decreases under its effect in atherosclerotic patients.…”