In recent years numerous studies have been made on the clearing effect exerted by heparin on hyperlipemic plasma, specially in connection with the problem of atherogenesis. The present paper deals with investigations, carried out on both animals and men, concerning the hypoeholesteremic, plasma-clearing, and lipotropie effects, as well as the inhibitory action on the electrocardiographs changes associated with alimentary hyperlipemia, exerted by orally active extracts of gastric juice and hog gastric mucosa.

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The hyperlipeniia induced by a fat meal in anginal patients is frequently associated with clinical and electrocardiographic changes suggesting transient coronary insufficiency. Gastric mucin administered to 10 anginal patients at the same time as a fat meal invariably prevented the hyperlipemnia, evaluated as increase of plasma optical density, and in one half of the cases it reduced the magnitude of the electrocardiographic changes as compared with the changes found in control experiments. Gastric mucin therefore exerts a powerful antilipemic and clearing action. Its inhibitory effect on the electrocardiographic changes associated with alimentary hyperlipemia is less evident than that of heparin.IN A previous paper1 on plasma turbidity and electrocardiographic changes associated with alimentary hyperlipemia, we demonstrated that both the foregoing changes were inhibited when heparin was administered intravenously at the same time as the fat meal. We discussed in that paper the interpretation of this phenomenon and its possible relationship with the pathogenesis of postprandial angina and arterial atheroma.Capraro and his associates,5 Cresseri,2-4 and Cantonej7-9 as a result of their researches on the biologic properties of hog gastric mucin extracts, recently clarified some points of considerable interest concerning the effect of such extracts on certain plasma conditions that many investigators believe to be related with atherogenesis or with frank atheromatous conditions.A variety of biologic properties has been ascribed to the mucin compound prepared from hog gastric mucosa. Among such properties are the capacity to bind vitamin B12 and thus render it undialyzable,24 and to act as growth factor for Lactobacillus bifidus, var. Penn, an antianemic action in mice, rats,5 and in human pernicious anlemia

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