Antilupus activity of copper (II)

Jendryczko, A; Drózdz, M; K, Magner

doi:10.1016/s0232-1513(85)80007-4

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Copper may also have a role in the immune system response to inflammation (67)(68)(69)(70)(71)(72)(73)(74). In inflammatory conditions, subjects exhibited higher mean serum copper concentrations related to disease activity (67,68).…”

Section: Prodrug Of β-D-n4-hydroxycytidine (Eidd-2801mentioning

confidence: 99%

“…Another study in a crescentic glomerulonephritis (Crgn) animal model showed the down-regulation of ceruloplasmin by RNA interference (RNAi), decreased markers of glomerular proinflammatory macrophage activation and suppressed a physiological response (73). Exogenous copper decreased the formation of systemic lupus erythematosus (SLE) cells in rats with a hydralazine induced collagen disease (74). Differences in inflammatory response were observed in rats fed with copper supplemented diet compared to standard diet (74).…”

Section: Prodrug Of β-D-n4-hydroxycytidine (Eidd-2801mentioning

confidence: 99%

“…Differences in inflammatory response were observed in rats fed with copper supplemented diet compared to standard diet (74). The (74). In addition to ceruloplasmin activity, copper chelation has been found to affect proteins involved in Fe metabolism, at the mRNA level, and in inflammatory diseases (69).…”

Section: Prodrug Of β-D-n4-hydroxycytidine (Eidd-2801mentioning

confidence: 99%

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COVID-19: The Potential Role of Copper and N-acetylcysteine (NAC) in a Combination of Candidate Antiviral Treatments Against SARS-CoV-2

Andreou

Trantza

Filippou

et al. 2020

In Vivo

102

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Background: On March 11, 2020, the World Health Organization (WHO) declared the outbreak of coronavirus disease (COVID-19) a pandemic. Since then, thousands of people have suffered and died, making the need for a treatment of severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) more crucial than ever. Materials and Methods: The authors carried out a search in PubMed, Clinical Trials.gov and New England Journal of Medicine (NEJM) for COVID-19 to provide information on the most promising treatments against SARS-CoV-2. Results: Possible COVID-19 agents with promising efficacy and favorable safety profile were identified. The results support the combination of copper, N-acetylcysteine (NAC), colchicine and nitric oxide (NO) with candidate antiviral agents, remdesivir or EIDD-2801, as a treatment for patients positive for SARS-CoV-2. Conclusion: The authors propose to study the effects of the combination of copper, NAC, colchicine, NO and currently used experimental antiviral agents, remdesivir or EIDD-2801, as a potential treatment scheme for SARS-COV-2. Nowadays, the world is facing a pandemic of a newly discovered coronavirus disease, named COVID-19, with 4,037,574 confirmed cases and 279,236 deaths on May 10, 2020, worldwide (1). The most affected countries so far are: People's Republic of China, the United States of America (USA), Spain, Italy, Germany, France, Iran and the UK (1). CoVs are a group of enveloped viruses with a positive-sense single-stranded RNA genome that infect the pulmonary system, the intestines, the liver and the nerve cells of animals and humans (2). The taxonomy of these viruses includes the following genera: Alphacoronavirus, Betacoronavirus, Gammacoronavirus and Deltacoronavirus (3, 4). In each genus, several species that affect humans include: Human coronavirus 229E, Human coronavirus NL63, Betacoronavirus 1 (Human coronavirus OC43), Human coronavirus HKU1, Severe acute respiratory syndromerelated coronavirus (SARS-CoV, SARS-CoV-2), Middle East respiratory syndrome-related coronavirus (MERS-CoV) and Infectious bronchitis virus (3, 4). Infection with CoVs begins when an envelope glycoprotein, the viral spike (S) protein, which attaches to the host cells' angiotensin converting enzyme 2 (ACE2) receptor (5). This allows the virus to enter the host cell (5) by endocytosis or by direct fusion with the host cell membranes (6). This is considered as the main function of this glycoprotein (6), which assembles into trimers on the surface of the virus in order to form the "corona", the crown appearance of the virus (7). The protein is organized into two domains: a N-terminal S1 domain responsible for receptor binding and a C-terminal S2 domain responsible for viral fusion (7). The S protein consists of a furin site (polybasic cleavage site-RRAR) at the boundary of its two domains (8). This allows effective cleavage by furin and other 1567 This article is freely accessible online.

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Section: Prodrug Of β-D-n4-hydroxycytidine (Eidd-2801mentioning

confidence: 99%

Section: Prodrug Of β-D-n4-hydroxycytidine (Eidd-2801mentioning

confidence: 99%

See 1 more Smart Citation

COVID-19: The Potential Role of Copper and N-acetylcysteine (NAC) in a Combination of Candidate Antiviral Treatments Against SARS-CoV-2

Andreou

Trantza

Filippou

et al. 2020

In Vivo

102

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“…Apesar das diferentes formulações utilizadas, grande parte dos ACHs ainda tem como efeitos secundários alterações no metabolismo de carboidratos, lipídios, triglicérides, colesterol e lipoproteínas [2][3][4][5][6]11 . Estudos mostram que os progestágenos são os principais responsáveis por essas alterações metabólicas devido a danos oxidativos, como exemplo a diminuição da atividade do sistema antioxidante dependente da glutationa (GSH) 7,8 . Alterações no perfil lipídico das usuárias de ACHs também têm sido citadas pelo fato de os progestágenos aumentarem os níveis de enzimas hepáticas produtoras de lipídios e lipoproteínas.…”

Section: Introductionunclassified

A Importância Da Suplementação Vitamínica Na Diminuição Do Risco Cardiovascular Em Usuárias De Anticoncepcionais Hormonais (Vitaminas E Diminuição Do Risco Cardiovascular)

Gauw

Albuquerque

2015

Rev. Cient. Fac. Med Campos

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Apesar das diferentes formulações utilizadas, grande parte dos anticoncepcionais hormonais (ACHs) ainda tem como efeitos secundários alterações no metabolismo lipídico e aumento nos danos oxidativos. Estes fatores estão diretamente relacionados ao desenvolvimento da doença arterial coronariana. Esta revisão de literatura tem como objetivo mostrar evidências experimentais realizadas enfatizando a possível prevenção do efeito dislipidêmico e oxidante dos ACHs a partir da reposição de vitaminas C e E, e com isto a redução do risco cardiovascular dessas mulheres. Foram analisadas literaturas que relacionam dislipidemia, oxidação de lipídios, risco cardiovascular e o potencial das vitaminas C e E no combate a essas alterações. Concluiu-se que a reposição dessas vitaminas, em usuárias de ACHs é eficiente na redução tanto da dislipidemia quanto de danos oxidativos e que deve ser considerada de grande importância para as usuárias de ACHs na diminuição do risco cardiovascular.

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Heavy Metals in Autoimmune Diseases: Too Much Noise in Autoimmunity

Sharif,

Amital

2024

Autoimmune Disorders

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Antilupus activity of copper (II)

Cited by 5 publications

References 11 publications

COVID-19: The Potential Role of Copper and N-acetylcysteine (NAC) in a Combination of Candidate Antiviral Treatments Against SARS-CoV-2

COVID-19: The Potential Role of Copper and N-acetylcysteine (NAC) in a Combination of Candidate Antiviral Treatments Against SARS-CoV-2

A Importância Da Suplementação Vitamínica Na Diminuição Do Risco Cardiovascular Em Usuárias De Anticoncepcionais Hormonais (Vitaminas E Diminuição Do Risco Cardiovascular)

Heavy Metals in Autoimmune Diseases: Too Much Noise in Autoimmunity

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