Antimalarial activity of a cis-terpenone

Mayer, DC Ghislaine; Bruce, Maimuna; Kochurova, Olga; Stewart, Jesse C.; Zhou, Qibing

doi:10.1186/1475-2875-8-139

Cited by 7 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Relatively low-cost treatment regiments are available against malaria, but the emergence and persistent spread of resistance against all existing therapies have aggravated the disease burden in endemic regions [ 66 , 67 ]. Based on their chemical nature, the currently used antimalarials can be grouped under nine classes (see Figure 2 ): 4-aminoquinolines, 8-aminoquinolines, amino-alcohols, sulfamines and sulfones, Biguanides, diaminopyrimidine, sesquiterpenes lactones, naphthoquinones, and antibiotics [ 68 ].…”

Section: Review and Discussionmentioning

confidence: 99%

Control of malaria and other vector-borne protozoan diseases in the tropics: enduring challenges despite considerable progress and achievements

et al. 2014

View full text Add to dashboard Cite

Vector-borne protozoan diseases represent a serious public health challenge, especially in the tropics where poverty together with vector-favorable climates are the aggravating factors. Each of the various strategies currently employed to face these scourges is seriously inadequate. Despite enormous efforts, vaccines—which represent the ideal weapon against these parasitic diseases—are yet to be sufficiently developed and implemented. Chemotherapy and vector control are therefore the sole effective attempts to minimize the disease burden. Nowadays, both strategies are also highly challenged by the phenomenon of drug and insecticide resistance, which affects virtually all interventions currently used. The recently growing support from international organizations and governments of some endemic countries is warmly welcome, and should be optimally exploited in the various approaches to drug and insecticide research and development to overcome the burden of these prevalent diseases, especially malaria, leishmaniasis, Human African Trypanosomiasis (HAT), and Chagas disease.

show abstract

Section: Review and Discussionmentioning

confidence: 99%

Control of malaria and other vector-borne protozoan diseases in the tropics: enduring challenges despite considerable progress and achievements

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The result showed that the monoacylated showed high activity and lower toxicity, while the diacylated showed lower activity, thus acylation only at the C-15 hydroxy group may be worthy of further antimalarial investigation. Mayer et al (2009) studied the activity of Oxidized Hydroxyl of Cis Terpenone (OHCT) against chloroquine and artemisinin resistant. The result showed that OHCT was more active than chloroquine on chloroquine resistant but less active against chloroquine sensitive while OHCT and chloroquine exhibited similar potency against chloroquine resistant clone.…”

Section: Anti-malarial Effectmentioning

confidence: 99%

“…The OHCT found even at low nano molar concentration, able to inhibit survival of artemisinin resistant isolates. It is therefore concluded that OHCT has the potential capabilities to be developed as anti-malarial lead compound especially as it is easily synthesized (Mayer et al, 2009).…”

Section: Anti-malarial Effectmentioning

confidence: 99%

“…Chan et al (2005) revealed that monoacylated eurycomanone displayed anti-plasmodial potency but toxicity was low in brine shrimp assay test. Mayer et al (2009) reported that hydroxy cis terpenone from E. longifolia displayed strong growth inhibitory against all stages of P. falciparum but not toxic to cultured human liver cells. There was a discouraging report by Hout et al (2006) where they revealed E. longfolia extracts showed low selectivity between human and plasmodium cells.…”

Section: Cytoselectivitymentioning

confidence: 99%

See 1 more Smart Citation

Review on Eurycoma longifolia Pharmacological and Phytochemical Properties

Mohamed¹,

Vejayan²,

Yusoff³

2015

J. of Applied Sciences

View full text Add to dashboard Cite

A B S T R A C TEurycoma longifolia or Tongkat Ali is famous for its aphrodisiac property and the traditional uses range from tonic after childbirth to treating malaria. Phytochemical studies revealed the presence of bioactive compounds such as quassinoids, alkaloids, squalene derivatives, tirucallane-type triterpenes and biphenylneolignans. Existing research revealed that plant has potential to treat various diseases and to replace the current treatment. Purpose of this article is to evaluate and summarize the existing literatures concerning phytochemical, biological and toxicological studies of E. longifolia. It is expected that critical evaluation will be useful for researchers working on the potential role of E. longifolia in treating diseases or for product development.

show abstract

“…Chemotherapy is central to any strategy for effective reduction of mortality related to malaria, since an efficient vaccine is yet to be approved [ 1 ]. The emergence and relentless spread of resistance against all the drugs in current use, including the newly introduced artemisinin-based combination therapy, have aggravated the disease burden in endemic regions [ 2 , 3 ]. Hence, there is an urgent need to discover new efficacious and safe anti-malarial drugs in order to face this situation.…”

Section: Introductionmentioning

confidence: 99%

Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark

Zofou

Kowa

Wabo

et al. 2011

Malar J

View full text Add to dashboard Cite

BackgroundMalaria is a major public health threat in Africa, and traditional medicine continues to play a key role in its control especially in rural areas. A bioassay-guided fractionation was carried out in order to evaluate the anti-malarial potential and the safety of the methanol extract of the Hypericum lanceolatum stem bark.MethodsThe anti-plasmodial activity was assayed by the lactate dehydrogenase method (pLDH) against the multidrug-resistant W2mef laboratory strain, and a field isolate (SHF4) of Plasmodium falciparum. Cytotoxicity tests were carried out using the LLC-MK2 monkey kidney epithelial cells.ResultsFive compounds were isolated from the most active and least cytotoxic ethylacetate sub-extract: betulinic acid (HLT1), 2,2',5,6'-tetrahydroxybenzophenone (HLT2), 5-hydroxy-3-methoxyxanthone (HLT3), 3-hydroxy-5-methoxyxanthone (HLT4) and HLT0 (yet to be identified). Three of the tested compounds presented significant anti-plasmodial activities (with 50% inhibitory concentration, IC50 < 5 μM), with 5-hydroxy-3-methoxyxanthone exerting the highest activity, followed by HLT0 and betulinic acid. All the compounds with significant anti-plasmodial activity were non-cytotoxic, except betulinic acid which showed a 50% cytotoxic concentration, CC50 of 25 μg/mL.ConclusionsThese findings justify the use of H. lanceolatum stem bark as anti-malarial by traditional healers of Western Cameroon, and could constitute a good basis for further studies towards development of new drug candidates or phytomedicines for malaria.

show abstract

Antimalarial activity of a cis-terpenone

Cited by 7 publications

References 17 publications

Control of malaria and other vector-borne protozoan diseases in the tropics: enduring challenges despite considerable progress and achievements

Control of malaria and other vector-borne protozoan diseases in the tropics: enduring challenges despite considerable progress and achievements

Review on Eurycoma longifolia Pharmacological and Phytochemical Properties

Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark

Contact Info

Product

Resources

About