Antimalarial activity of Ageratum conyzoides in combination with chloroquine and artesunate

Chinwe, Ukwe; Obinna, Ekwunife; A, Epueke Ebele; M, Ubaka Chukwuemeka

doi:10.1016/s1995-7645(11)60005-9

Cited by 8 publications

(1 citation statement)

References 22 publications

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“…Furthermore, it is one of the proud remedies used traditionally for prostate complaints and venereal diseases [63]. Other indigenous practices of the world define the plant as an anti-diabetic [64], anti-inflammatory, and anti-microbial [65] treatment, curing diseases such as cephalgia, dyspnea, enteralgia, fever [66], malaria [67,68], spasm [33], and pneumonia [69], as well as use as an insecticidal [70]. Studies evince various prevalent traditional uses [71,72] interfused along with modern biological potential of this remarkable plant, such as use as an anti-convulsant [73], acaricidal [74], nematocidal, hypoglycemic or antiglycemic, antioxidant [75][76][77], anticoccidial [78], and as a cure for urolithiasis [79].…”

Section: Indiamentioning

confidence: 99%

Ageratum conyzoides L. and Its Secondary Metabolites in the Management of Different Fungal Pathogens

et al. 2021

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Ageratum conyzoides L. (Family—Asteraceae) is an annual aromatic invasive herb, mainly distributed over the tropical and subtropical regions of the world. It owns a reputed history of indigenous remedial uses, including as a wound dressing, an antimicrobial, and mouthwash as well as in treatment of dysentery, diarrhea, skin diseases, etc. In this review, the core idea is to present the antifungal potential of the selected medicinal plant and its secondary metabolites against different fungal pathogens. Additionally, toxicological studies (safety profile) conducted on the amazing plant A. conyzoides L. are discussed for the possible clinical development of this medicinal herb. Articles available from 2000 to 2020 were reviewed in detail to exhibit recent appraisals of the antifungal properties of A. conyzoides. Efforts were aimed at delivering evidences for the medicinal application of A. conyzoides by using globally recognized scientific search engines and databases so that an efficient approach for filling the lacunae in the research and development of antifungal drugs can be adopted. After analyzing the literature, it can be reported that the selected medicinal plant effectively suppressed the growth of numerous fungal species, such as Aspergillus, Alternaria, Candida, Fusarium, Phytophthora, and Pythium, owing to the presence of various secondary metabolites, particularly chromenes, terpenoids, flavonoids and coumarins. The possible mechanism of action of different secondary metabolites of the plant against fungal pathogens is also discussed briefly. However, it was found that only a few studies have been performed to demonstrate the plant’s dosage and safety profile in humans. Considered all together, A. conyzoides extract and its constituents may act as a promising biosource for the development of effective antifungal formulations for clinical use. However, in order to establish safety and efficacy, additional scientific research is required to explore chronic toxicological effects of ageratum, to determine the probability of interactions when used with different herbs, and to identify safe dosage. The particulars presented here not only bridge this gap but also furnish future research strategies for the investigators in microbiology, ethno-pharmacology, and drug discovery.

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Section: Indiamentioning

confidence: 99%

Ageratum conyzoides L. and Its Secondary Metabolites in the Management of Different Fungal Pathogens

et al. 2021

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Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L.

Yadav

Ganie

Singh

et al. 2019

Phytotherapy Research

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Ageratum conyzoides L. (Asteraceae) is an invasive aromatic herb with immense therapeutic importance. The herb is distributed in tropical and subtropical regions. A. conyzoides has imparted numerous ethnomedicinal uses because it has been used to cure various ailments that include leprosy, skin disorders, sleeping sickness, rheumatism, headaches, dyspnea, toothache, pneumonia and many more. A number of phytoconstituents have been scrutinized such as alkaloids, flavonoids, terpenes, chromenes, and sterols from almost every part of this plant. These phytoconstituents have shown diverse pharmacological properties including antimicrobial, anti‐inflammatory, analgesic, antioxidant, anticancer, antiprotozoal, antidiabetic, spasmolytic, allelopathy, and many more. The plant A. conyzoides has provided a platform for doing pharmaceutical and toxicological research in order to isolate some promising active compounds and authenticate their safety in clinical uses. A. conyzoides provides principal information for advanced studies in the field of pharmaceutical industries and agriculture. Present review article describes the cytogenetics, ethnobotany, phytochemistry, pharmacology, and toxicological aspects of A. conyzoides.

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Screening for Streptococcus pyogenes antibacterial and Candida albicans antifungal bioactivities of organic compounds in natural essential oils of Piper betle L., Cleistocalyx operculatus L. and Ageratum conyzoides L.

Thuý

Hiếu

et al. 2020

Chem. Pap.

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Antimalarial activity of Ageratum conyzoides in combination with chloroquine and artesunate

Cited by 8 publications

References 22 publications

Ageratum conyzoides L. and Its Secondary Metabolites in the Management of Different Fungal Pathogens

Ageratum conyzoides L. and Its Secondary Metabolites in the Management of Different Fungal Pathogens

Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L.

Screening for Streptococcus pyogenes antibacterial and Candida albicans antifungal bioactivities of organic compounds in natural essential oils of Piper betle L., Cleistocalyx operculatus L. and Ageratum conyzoides L.

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