Antimalarial activity of crude extracts from nine African medicinal plants

Kaou, Ali Mohamed; Mahiou-Leddet, Valérie; Hutter, Sébastien; Sidi, Aïnouddine; Hassani, Saïd; Ibrahim, Yahaya; Azas, Nadine; Ollivier, Évelyne

doi:10.1016/j.jep.2007.11.001

Cited by 104 publications

(64 citation statements)

References 24 publications

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“…From twelve extracts from three species of Piper from Comores, only the dichloromethane extract of P. capense showed activity against P. falciparum W2 (7 µg/mL) (Kaou et al, 2008). By bioassay-guided purification from hexane extract of P. hostmannianum var.…”

Section: Larvicidalmentioning

confidence: 99%

Chemical composition of essential oils of Piper jacquemontianum and Piper variabile from Guatemala and bioactivity of the dichloromethane and methanol extracts

Cruz¹,

Cáceres²,

Alvarez³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The essential oils from two native species from Guatemala were studied for their chemical composition and the dichloromethane and methanol extracts for their biological activity. A GC-MS analysis of the essential oil from Piper jacquemontianum Kunth, Piperaceae, showed 34 constituents, consisting mainly of linalool (69.4%), while Piper variabile C. DC. essential oil had 36 constituents, camphor (28.4%), camphene (16.6%) and limonene (13.9%) being the major components. Dichloromethane extracts of both species were cytotoxic against MCF-7, H-460 and SF-268 cell lines (<7 µg/mL). Dichloromethane extract of P. jacquemontianum was slightly active against bacteria (0.5 mg/mL), was active against promastigotes of Leishmania (20.4-61.0 µg/mL), and epimastigotes of Trypanosoma cruzi (51.9 µg/mL). The methanol extract of P. variabile showed antimalarial activity against Plasmodium falciparum F32 (4.5 µg/mL), and the dichloromethane extract against Leishmania (55.8-76.3 µg/mL) and T. cruzi (45.8 µg/mL). None of the extracts from the two species was active against Aedes aegypti larvae and Artemia salina nauplii.

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Section: Larvicidalmentioning

confidence: 99%

Chemical composition of essential oils of Piper jacquemontianum and Piper variabile from Guatemala and bioactivity of the dichloromethane and methanol extracts

Cruz¹,

Cáceres²,

Alvarez³

et al. 2011

Rev. bras. farmacogn.

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“…This was the case for Trema orientalis L. Blume Ulmaceae (Verotta et al, 2001), Piliostigma thonningii Schum. Leguminosae/ Caesalpinioideae (Clarkson et al, 2004) and Jatropha curcas L. Euphorbiaceae (Kaou et al, 2008). Differences in the antiplasmodial activity of some of the plant extracts observed in this study and previous studies may be as a result of many factors such as the season, age, intra-species variation, part collected, soil, climate, methods used for extraction and bioassay (Muregi et al, 2003).…”

Section: Resultsmentioning

confidence: 48%

In vitroantiplasmodial activity and toxicity assessment of some plants from Nigerian ethnomedicine

Abiodun

Gbotosho

Ajaiyeoba

et al. 2010

Pharmaceutical Biology

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“…The fresh leaves of this plant are used together with Ocimum americanum and O. gratissimum (Lamiaceae) for the treatment of malaria in different communities found in Africa (KAOU et al, 2008). This species has other uses related to the control of malaria (and other insect-born diseases) such as repellency against Culicidae, Muscidae and Dictyoptera.…”

Section: Annona Squamosamentioning

confidence: 99%

Plants of the Annonaceae traditionally used as antimalarials: a review

et al. 2014

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ABSTRACT-Species of the Annonaceae family are used all over the tropics in traditional medicine in tropical regions for the treatment of malaria and other illnesses. Phytochemical studies of this family have revealed chemical components which could offer new alternatives for the treatment and control of malaria. Searches in scientific reference sites (SciFinder Scholar, Scielo, PubMed, ScienceDirect and ISI Web of Science) and a bibliographic literature search for species of Annonaceae used traditionally to treat malaria and fever were carried out. This family contains 2,100 species in 123 genera. We encountered 113 articles reporting medicinal use of one or more species of this family including 63 species in 27 genera with uses as antimalarials and febrifuges. Even though the same species of Annonaceae are used by diverse ethnic groups, different plant parts are often chosen for applications, and diverse methods of preparation and treatment are used. The ethanol extracts of Polyalthia debilis and Xylopia aromatica proved to be quite active against Plasmodium falciparum in vitro (median inhibition concentration, IC 50 < 1.5 µg/mL). Intraperitoneal injection of Annickia chlorantha aqueous extracts (cited as Enantia chlorantha) cleared chloroquine-resistant Plasmodium yoelii nigeriensis from the blood of mice in a dose-dependant manner. More phytochemical profiles of Annonaceous species are required; especially information on the more commonly distributed antimalarial compounds in this family.

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Antimalarial activity of crude extracts from nine African medicinal plants

Cited by 104 publications

References 24 publications

Chemical composition of essential oils of Piper jacquemontianum and Piper variabile from Guatemala and bioactivity of the dichloromethane and methanol extracts

Chemical composition of essential oils of Piper jacquemontianum and Piper variabile from Guatemala and bioactivity of the dichloromethane and methanol extracts

In vitroantiplasmodial activity and toxicity assessment of some plants from Nigerian ethnomedicine

Plants of the Annonaceae traditionally used as antimalarials: a review

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