2010
DOI: 10.1055/s-0030-1250028
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Antimalarial Activity ofAspilia pruliseta, a Medicinal Plant from Uganda

Abstract: Aspilia pruliseta Schweinf. (Asteraceae) is a medicinal plant indigenous to Uganda and the neighboring countries of East Africa. It has been used extensively by the rural population for the treatment of fevers and malaria. During the antimalarial evaluation of this plant, four nontoxic diterpenes were isolated that possessed moderate activity against chloroquine-sensitive (D6) and chloroquine-resistant (W2) clones of Plasmodium falciparum, with IC(50) values ranging from 14 to 23 µM. These moderately active co… Show more

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Cited by 14 publications
(17 citation statements)
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“…On the other hand, otostegindiol (25, 50, and 100 mg/kg) against Plasmodium berghei exhibited a significant chemosuppression effect (Endale et al, 2013). It should be mentioned that, till date, a number of promising diterpenes and their derivatives have been isolated from natural sources (Pouvelle et al, 1994;Uys et al, 2002;Riel et al, 2002;Kuria et al, 2002;Köhler et al, 2002;Clarkson et al, 2003;Wei et al, 2004;Loyola et al, 2004;Ospina et al, 2005;Kalauni et al, 2006;Ojo-Amaize et al, 2007;Koka et al, 2009;Lane et al, 2009;Wei et al, 2010;Lin et al, 2010;Wangchuk et al, 2010;Stout et al, 2010;Sebisubi et al, 2010;Stout et al, 2011;Cocquyt et al, 2011;Alasbahi and Melzig, 2012;Ebrahimi et al, 2013;Ehrhardt et al, 2013;Walter et al, 2013;Batista et al, 2013;González et al, 2014;Ma et al, 2014;Avilés et al, 2015;Gbedema et al, 2015;Annan et al, 2015;Sadashiva et al, 2015;Namukobe et al, 2015;Ahmad et al, 2016).…”
Section: Resultsmentioning
confidence: 99%
“…On the other hand, otostegindiol (25, 50, and 100 mg/kg) against Plasmodium berghei exhibited a significant chemosuppression effect (Endale et al, 2013). It should be mentioned that, till date, a number of promising diterpenes and their derivatives have been isolated from natural sources (Pouvelle et al, 1994;Uys et al, 2002;Riel et al, 2002;Kuria et al, 2002;Köhler et al, 2002;Clarkson et al, 2003;Wei et al, 2004;Loyola et al, 2004;Ospina et al, 2005;Kalauni et al, 2006;Ojo-Amaize et al, 2007;Koka et al, 2009;Lane et al, 2009;Wei et al, 2010;Lin et al, 2010;Wangchuk et al, 2010;Stout et al, 2010;Sebisubi et al, 2010;Stout et al, 2011;Cocquyt et al, 2011;Alasbahi and Melzig, 2012;Ebrahimi et al, 2013;Ehrhardt et al, 2013;Walter et al, 2013;Batista et al, 2013;González et al, 2014;Ma et al, 2014;Avilés et al, 2015;Gbedema et al, 2015;Annan et al, 2015;Sadashiva et al, 2015;Namukobe et al, 2015;Ahmad et al, 2016).…”
Section: Resultsmentioning
confidence: 99%
“…This plant is widely spread in East, Central, and Southern Africa, especially in open woodlands and grasslands [ 41 , 42 ]. In East Africa (especially Kenya, Rwanda, and Uganda), the plant has been documented to manage and treat cough, stomach infections, burns, bruises, lacerations, wounds, pimples, ears-, eye-, nose infections, kwashiorkor, fever, worms, and diabetes mellitus with little or no scientific validation [ 40 , 42 , 43 , 44 , 45 , 46 , 47 ]. There are reports on antiviral activity [ 42 ], molluscicidal activity [ 48 ], complement modulating activity [ 49 ], antihelmintic activity [ 50 ], antimalarial, and hypoglycaemic activities [ 40 , 47 , 51 ] of A. pluriseta .…”
Section: Introductionmentioning
confidence: 99%
“…Four nontoxic diterpenes isolated from Aspilia pruliseta were found to possess a moderate activity (IC 50 , 14 to 23 μM) against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of P. falciparum (Sebisubi et al 2010). The ethanolic extracts of Artemisia annua and A. absinthium showed an antiplasmodial activity against the multidrug resistant and sensitive strains of P. falciparum.…”
Section: Discussionmentioning
confidence: 99%