Antimalarial Activity of Prodigiosin

Castro, Albert J.

doi:10.1038/213903a0

Cited by 96 publications

(43 citation statements)

References 7 publications

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“…Prodigiosin (99) and heptylprodigiosin (100), the latter isolated fromproteobacteria [105] (Fig. 6), exhibited potent antiplasmodial activity, although their high general toxicity precluded any potential development as a clinical agent [106]. The stable fluorescent red pigment cycloprodigiosin as hydrochloric salt (101) suppressed T cell proliferation leading to apoptosis [107].…”

Section: Scheme13 Synthesis Of Manzamine a By Hamannmentioning

confidence: 99%

Synthesis of Marine Natural Products with Antimalarial Activity

Mancini¹,

Guella²,

Defant

2008

MRMC

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Section: Scheme13 Synthesis Of Manzamine a By Hamannmentioning

confidence: 99%

Synthesis of Marine Natural Products with Antimalarial Activity

Mancini¹,

Guella²,

Defant

2008

MRMC

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“…However, a possible role in dispersion as well as an active role in competitive survival has been reported (Williams & Qadri, 1980;Burger & Bennett, 1985;Matsuyama et al, 1986;Demain, 1995). In addition, prodigiosin and family members have been identified as having extremely broad antibacterial, antimalarial, antifungal and antiprotozoal activities (Castro, 1967;Williams & Qadri, 1980;Demain, 1995). Prodigiosins also have been found to have potent immunosuppressive, proapoptic and anticancer properties (reviewed in Bennett & Bentley, 2000;Manderville, 2001;Perez-Tomas et al, 2003).…”

Section: Prodigiosin Productionmentioning

confidence: 99%

Quorum sensing inSerratia

2007

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Many bacteria use cell-cell communication to monitor their population density, synchronize their behaviour and socially interact. This communication results in a coordinated gene regulation and is generally called quorum sensing. In gram-negative bacteria, the most common quorum signal molecules are acylated homoserine lactones (AHLs), although other low-molecular-mass signalling molecules have been described such as Autoinducer-2 (AI-2). The phenotypes that are regulated in Serratia species by means of AHLs are remarkably diverse and of profound biological and ecological significance, and often interconnected with other global regulators. Furthermore, AHL- and AI-2-mediated systems (less profoundly studied) are continuously being discovered and explored in Serratia spp., many having interesting twists on the basic theme. Therefore, this review will highlight the current known quorum sensing systems in Serratia spp., including the important nosocomial pathogen Serratia marcescens.

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“…The in vivo activities of metacycloprodigiosin hydrochloride and several other prodigiosins against Plasmodium berghei in mice have been reported (2,6). According to the literature (6), elongation of the mean survival time of P. berghei-infected mice by oral administration of metacycloprodigiosin hydrochloride was observed with a dose of 20 mg/kg.…”

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confidence: 94%

Potent In Vitro Antimalarial Activity of Metacycloprodigiosin Isolated fromStreptomycesspectabilisBCC 4785

Isaka

Jaturapat

Kramyu

et al. 2002

Antimicrob Agents Chemother

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Bioassay-guided fractionation of the extract from the fermentation broth of Streptomyces spectabilis BCC 4785 led to the isolation of three principle antimalarial agents, metacycloprodigiosin, bafilomycin A 1 , and spectinabilin. Metacycloprodigiosin exhibited potent in vitro activity against Plasmodium falciparum K1, with a 50% inhibitory concentration of 0.0050 ؎ 0.0010 g/ml, while its cytotoxicity was much weaker.

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Antimalarial Activity of Prodigiosin

Cited by 96 publications

References 7 publications

Synthesis of Marine Natural Products with Antimalarial Activity

Synthesis of Marine Natural Products with Antimalarial Activity

Quorum sensing inSerratia

Potent In Vitro Antimalarial Activity of Metacycloprodigiosin Isolated fromStreptomycesspectabilisBCC 4785

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