Antimalarial Medications in Dermatology

The benefit of combining hydroxychloroquine with quinacrine in the treatment of SLE patients

“…However, the question of whether they exercise their photoprotective effect due to skin deposition remains controversial. 19,20 Whether the synergistic/additive effect reported here of the combined HCQ and Qn therapy is due to the different absorption spectrum of each component [i.e. HCQ is mainly absorbed in the UV region (peaks 330 and 343 reas).…”

En coup de sabre morphea and Parry-Romberg syndrome: A retrospective review of 54 patients

“…However, even these studies are largely case series and small nonrandomized trials. 12,18,[24][25][26][27][28][29][30][31][32][33] Our study represents the largest retrospective review of medications used to treat patients with en coup de sabre morphea with or without ParryRomberg syndrome. Hydroxychloroquine and methotrexate were found to be the two most commonly used medications at our institution; however, the small sample size and absence of a control group make it impossible to draw any definite conclusions regarding their efficacy.…”

Significant improvement in ulcerative necrobiosis lipoidica with hydroxychloroquine

“…Hydroxychloroquine is used in the treatment of other granulomatous diseases, such as granuloma annulare and sarcoidosis 15 . In our patient, the ulceration almost completely healed with residual skin atrophy and postinflammatory hyperpigmentation after the administration of hydroxychloroquine.…”

“…Hydroxychloroquine is an antimalarial agent having immunosuppressive and anti‐inflammatory effects. In addition, hydroxychloroquine inhibits the chemotaxis of macrophages and prevents platelet aggregation, 15 which have been proposed in the pathogenesis of NL 6 . In vitro studies have shown that antimalarials decrease the production of tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL6) and interferon‐γ (IFN‐γ).…”