Antimalarial Naphthoquinones fromNepenthes thorelii

Abstract

Roots of Nepenthes thorelii yielded plumbagin, 2-methylnaphthazarin, octadecyl caffeate, isoshinanolone, and droserone. In addition, seven derivatives were prepared from plumbagin. Each of these natural and semisynthetic compounds was evaluated for in vitro antimalarial potential.

Plumbagin production by root cultures of Plumbago rosea

“…antimalarial (Likhitwitayawuid et al 1998), antimicrobial (Didry et al 1994), anticancer (Parimala and Sachdanandam, 1993), cardiotonic (Itoigawa et al 1991) and antifertilityaction (Bhargava, 1984). At present, the most exploited source of plumbagin are the roots of Plumbago spp.…”

Ethnobotanical, Phytochemical, and Pharmacological Properties of Nepenthes Species: A Review

“…Plumbagin, droserone, hydroxydroserone, and other four new quinones including nepenthone-A, nepenthone-B, nepenthone-C, and nepenthone-E were obtained from Nepenthes rafflesiana roots, while the fifth quinone, nepenthone-D was identified [30]. Likhitwitayawuid et al isolated 2-methylnaphthazarin, droserone, isoshinanolone, octadecylcaffeate, and plumbagin from the roots of Nepenthes thorelii [20] [22]. The compounds epishinanolone, isoshinanolone, kaempferol, plumbagin, quercetin, and shinanolone were successfully isolated from the leaves of N. gracilis by Aung et al [26].…”

“…have been utilized in traditional medicine system to treat and control different ailments including gastrointestinal discomfort, such as dysentery, stomachache, and bed-wetting among others [17]. A wide range of phytochemicals were identified and isolated from different species of Nepenthes [18][19][20][21][22]. The previous researches showed that Nepenthes spp.…”

“…The previous researches showed that Nepenthes spp. exhibited many pharmacological actions, including antibacterial, antifungal, antimalarial antioxidant, antidiabetic, and hypolipidemic among others [19][20][21]23]. The previous studies as mentioned above indicated that Nepenthes spp.…”

Construction and Expression of Specificity-Improved Single-Chain Variable Fragments against the Bioactive Naphthoquinone, Plumbagin

“…1) is a naturally occurring yellow pigment mainly isolated from the genus Plumbago (Plumbaginaceae), which have especially been attracted much attention as a drug candidate. It has been shown to have various pharmacologic activities against cancer, 7) fungi, 8) malaria, 9) insects, 10) and Helicobacter pylori. 11) In addition, PL is capable of inhibiting cell proliferation by inducing autophagic cell death.…”