Antimalarials fromStephania venosa, Prismatomeris sessiliflora, Diospyros montanaandMurraya siamensis1

Likhitwitayawuid, Kittisak; Dej-adisai, Sukanya; Jongbunprasert, Vichien; Krungkrai, Jerapan

doi:10.1055/s-2006-960858

Cited by 51 publications

(35 citation statements)

References 3 publications

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“…Antibacterial activity has been shown (Adeniyi et al, 1996;Sanogo et al, 1998). Other Diospyros species showed mainly antimalarial (Likhitwatayawuid et al, 1999), antiinflammatory (Recio et al, 1995), hypotensive (Funayama and Hikino, 1979) and oral antimicrobial (Cai et al, 2000) activities.…”

Section: Discussionmentioning

confidence: 99%

Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture

Belemtougri

Constantin

Cognard

et al. 2006

J. Zhejiang Univ. - Sci. B

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Crude decoction, aqueous and ethanolic extracts of two medicinal plants (Psidium guajava and Diospyros mespiliformis), widely used in the central plateau of Burkina Faso to treat many diseases were evaluated for their antagonistic effects on caffeine induced calcium release from sarcoplasmic reticulum of rat skeletal muscle cells. These different extracts showed a decrease of caffeine induced calcium release in a dose dependent manner. Comparison of the results showed that Psidium guajava leaf extracts are more active than extracts of Diospyros mespiliformis and that crude decoctions show better inhibitory activity. The observed results could explaine their use as antihypertensive and antidiarrhoeal agents in traditional medicine, by inhibiting intracellular calcium release.

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Section: Discussionmentioning

confidence: 99%

Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture

Belemtougri

Constantin

Cognard

et al. 2006

J. Zhejiang Univ. - Sci. B

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“…Resonances in the H-COSY spectrum of 4 revealed the connectivity from HÀC(5') to HÀC (7'), and also showed couplings between MeÀC(2) and HÀC (3), and HÀC (6) and HÀC (7). The HMBCspectrum of isodiospyrol A (4) established the partial structure from C(1) to C(8); demonstrating correlations from MeÀC(2) H-atoms to C(1), C(2), and C(3); HÀC (3) to C(4); HOÀC(4) to C(4), C(4a), and C(3); HÀC (6) to C(4a) and C (8); and HÀC (7) to C(5) and C(8a). The HMBC spectral data also assisted in partial structure assembling from C(1') to C (8'), from which the following correlations were seen; HOÀC(1') to C(1'), C(2'), and C(8'a); MeÀC(3') H-atoms to C(2'), C(3'), and C(4'); HÀC(4') to C(5') and MeÀC(3') C-atom; HÀC(5') to C(4'), C(4'a), and C(8'a); and both HÀC(6') and HÀC (7') to C(8').…”

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confidence: 99%

Bioactive Deoxypreussomerins and Dimeric Naphthoquinones fromDiospyros ehretioides Fruits: Deoxypreussomerins May Not Be Plant Metabolites But May Be from Fungal Epiphytes or Endophytes

Prajoubklang

Sirithunyalug

Charoenchai

et al. 2005

C&B

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Deoxypreussomerin derivatives, palmarumycins JC1 (1) and JC2 (2), and two dimeric naphthoquinones, isodiospyrin (3) and its new derivative isodiospyrol A (4), were isolated from dried fruits of Diospyros ehretioides. Structures of the isolated compounds were elucidated by spectroscopic analyses. Palmarumycins were not found in the extract of freshly collected fruits; however, they were present in dried fruit extract. The absence of palmarumycins in fresh fruits of D. ehretioides, together with the chemotaxonomic point of view, we proposed that palmarumycins JC1 (1) and JC2 (2) are more likely to be fungal metabolites, i.e., endophytes or epiphytes. The isolation of palmarumycins 1 and 2 from dried D. ehretioides fruits could be reproducible; both plant samples collected in the years 2002 and 2004 provided the same result, and, therefore, symbiont fungal strains should be specific to the plant host, D. ehretioides, and they can grow on the fruits during drying the sample. Palmarumycin JC1 (1) did not exhibit antimalarial, antifungal, antimycobacterial, and cytotoxic activities. Palmarumycin JC2 (2) exhibited antimalarial (IC50 4.5 microg/ml), antifungal (IC50 12.5 microg/ml), antimycobacterial (MIC 6.25 microg/ml), and cytotoxic (IC50 11.0 microg/ml for NCI-H187 cell line) activities. In our bioassay systems, isodiospyrin (3) did not exhibit antimycobacterial, antifungal, antimalarial, and cytotoxic activities. Isodiospyrol A (4) exhibited antimalarial (IC50 2.7 microg/ml) and antimycobacterial (MIC 50 microg/ml) activities, but was inactive towards Candida albicans. Compound 4 also exhibited cytotoxicity against BC cells (IC50 12.3 microg/ml), but not towards KB and Vero cell lines.

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“…Accumulating lines of evidence reported that the genus Stephania could be a potential source of biologically active compounds which might be used as lead molecules for development of novel drugs (Charles et al, 1987). Tubers of this plant have been used in Thai traditional medicine for nerve tonic, aphrodisiac (Potduang et al, 2003), appetizer and for treatment of asthma, hyperglycemia (Moongkarndi et al, 2004) and anti-malarial activities (Likhitwitayawuid et al, 1999). In addition, some of the isolated alkaloids were reported to exert acetylcholinesterase inhibitors (Ingkaninan et al, 2006), anti-cancer and anti-oxidative activities (Jongsomboonkusol, 2005;Leewanich et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

EVALUATION OF NEUROPHARMACOLOGICAL ACTIVITIES OF STEPHANIA VENOSA HERB CONSUMPTION IN HEALTHY RATS

Tong-Un¹,

Phachonpai²,

Muchimapura³

et al. 2012

American Journal of Agricultural and Biological Sciences

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Public concern on mental health has noticeably increased given the high prevalence of neuropsychiatric disorders especially anxiety and depression. Most of the drugs for these conditions used nowadays have adverse side effects so the need for newer, better-tolerated and more efficacious treatments is remaining high. Growing attention is being paid to traditional herbal medicines. Stephania venosa Spreng (S. venosa; SV) is a Thai traditional herb which has been used for cancer treatment as well as an aphrodisiac. In addition, accumulating lines of evidence reported that the ethanol extract of SV exhibited an antioxidant and exerted acetylcholinesterase inhibitory. However, the in vivo neurophamacological activities of this plant have never been studied. The aim of this study was to examine the neurophamacological effects of a crude extract of SV introduced orally at various doses ranging from 5, 10 and 20 mg kg −1 BW once daily for a period of 2 weeks. The anxiolytic and anti-depression like activities were determined after single administration, 1 and 2 weeks of treatment using elevated plus maze and forced swimming test respectively. Only SV 20 mg kg −1 treated rats exhibited a significant anxiolytic effect at all treatment duration. Unfortunately, this substance failed to show anti-depression like activity. Our findings provide a potential of the SV consumption might be used as a novel therapeutic strategy for the anti-anxiety disorder. However, further investigations about possible active ingredients and the precise underlying mechanisms are still necessary.

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Antimalarials fromStephania venosa, Prismatomeris sessiliflora, Diospyros montanaandMurraya siamensis¹

Cited by 51 publications

References 3 publications

Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture

Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture

Bioactive Deoxypreussomerins and Dimeric Naphthoquinones fromDiospyros ehretioides Fruits: Deoxypreussomerins May Not Be Plant Metabolites But May Be from Fungal Epiphytes or Endophytes

EVALUATION OF NEUROPHARMACOLOGICAL ACTIVITIES OF <i>STEPHANIA VENOSA</i> HERB CONSUMPTION IN HEALTHY RATS

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