Antimicrobial activities of ethanol and butanol fractions of white rose petal extract

Park, Dongsun; Shin, Kyungha; Choi, Young–Jin; Guo, Haiyu; Cha, Yeseul; Kim, Sa-Hyun; Han, Nam Soo; Joo, Seong Soo; Choi, Jae Kwon; Lee, Yoon Bok; Choi, Ehn‐Kyoung; Kim, Jong Bae; Kim, Yun-Bae

doi:10.1016/j.yrtph.2016.01.011

Cited by 17 publications

(13 citation statements)

References 39 publications

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“…The high sensitivity of bacteria Y. enterocolitica to other plant extracts has already been confirmed by other authors. The MIC values of plant extracts for these bacteria were comparable to the values obtained for S. aureus [58,59]. The similar study performed by another team also showed differences in the antibacterial activity of ethanol extracts of V. officinalis prepared from various parts of the plant.…”

Section: Biological Activitiessupporting

confidence: 81%

Production of Verbascoside, Isoverbascoside and Phenolic Acids in Callus, Suspension, and Bioreactor Cultures of Verbena officinalis and Biological Properties of Biomass Extracts

et al. 2020

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Callus, suspension and bioreactor cultures of Verbena officinalis were established, and optimized for biomass growth and production of phenylpropanoid glycosides, phenolic acids, flavonoids and iridoids. All types of cultures were maintained on/in the Murashige and Skoog (MS) media with 1 mg/L BAP and 1 mg/L NAA. The inoculum sizes were optimized in callus and suspension cultures. Moreover, the growth of the culture in two different types of bioreactors—a balloon bioreactor (BB) and a stirred-tank bioreactor (STB) was tested. In methanolic extracts from biomass of all types of in vitro cultures the presence of the same metabolites—verbascoside, isoverbascoside, and six phenolic acids: protocatechuic, chlorogenic, vanillic, caffeic, ferulic and rosmarinic acids was confirmed and quantified by the HPLC-DAD method. In the extracts from lyophilized culture media, no metabolites were found. The main metabolites in biomass extracts were verbascoside and isoverbascoside. Their maximum amounts in g/100 g DW (dry weight) in the tested types of cultures were as follow: 7.25 and 0.61 (callus), 7.06 and 0.48 (suspension), 7.69 and 0.31 (BB), 9.18 and 0.34 (STB). The amounts of phenolic acids were many times lower, max. total content reached of 26.90, 50.72, 19.88, and 36.78 mg/100 g DW, respectively. The highest content of verbascoside and also a high content of isoverbascoside obtained in STB (stirred-tank bioreactor) were 5.3 and 7.8 times higher than in extracts from overground parts of the parent plant. In the extracts from parent plant two iridoids—verbenalin and hastatoside, were also abundant. All investigated biomass extracts and the extracts from parent plant showed the antiproliferative, antioxidant and antibacterial activities. The strongest activities were documented for the cultures maintained in STB. We propose extracts from in vitro cultured biomass of vervain, especially from STB, as a rich source of bioactive metabolites with antiproliferative, antioxidant and antibacterial properties.

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Section: Biological Activitiessupporting

confidence: 81%

Production of Verbascoside, Isoverbascoside and Phenolic Acids in Callus, Suspension, and Bioreactor Cultures of Verbena officinalis and Biological Properties of Biomass Extracts

et al. 2020

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“…There was variability in the study regions for the selected manuscripts, with 25% of the papers coming from Asia ( Moon et al, 2011 ; Asha et al, 2013 ; Manayi et al, 2013 ; Wang et al, 2014 ; Park et al, 2016 ; Ibrahim et al, 2018 ; Kim et al, 2018 ; Lu et al, 2018 ; Saravanakumar et al, 2019 ; Ma X. et al, 2020 ; Das et al, 2020 ), 56.82% from America, of which 40.91% were from South America ( Adzu et al, 2015 ; Almeida et al, 2019 ; Arunachalam et al, 2019 ; Borges et al, 2020 ; da Silva Junior et al, 2016 ; de Cássia dos Santos et al, 2019 ; Garro et al, 2015 ; Klein-Júnior et al, 2013 ; Marcial et al, 2014 ; Mazzolin et al, 2010 ; Minozzo et al, 2016 ; Miranda et al, 2015 ; Mota Da Silva et al, 2015 ; Oliveira et al, 2015 ; Pastene et al, 2014 ; Ribeiro et al, 2013 ; Santos et al, 2012 ; Spósito et al, 2019 ) and 15.91% from North America ( Ankolekar et al, 2011 ; Brown and Jiang, 2013 ; Escobedo Hinojosa et al, 2014 ; Palacios-Espinosa et al, 2014 ; Espinosa-Rivero et al, 2015 ; Egas et al, 2018 ; Gomez-Chang et al, 2018 ), 9.09% of the articles originated from the Africa ( Okeleye et al, 2011 ; Lawal et al, 2014 ; Hamad et al, 2015 ; Fahmy et al, 2020 ), and 9,09% from the Europe ( Bisignano et al, 2013 ; Cardoso et al, 2018 ; Zengin et al, 2018 ; Cesa et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

Flavonoids-Rich Plant Extracts Against Helicobacter pylori Infection as Prevention to Gastric Cancer

et al. 2022

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Gastric cancer is the fifth most common and fourth type to cause the highest mortality rates worldwide. The leading cause is related to Helicobacter pylori (H. pylori) infection. Unfortunately, current treatments have low success rates, highlighting the need for alternative treatments against carcinogenic agents, specifically H. pylori. Noteworthy, natural origin products contain pharmacologically active metabolites such as flavonoids, with potential antimicrobial applications.Objective: This article overviews flavonoid-rich extracts’ biological and pharmacological activities. It focuses on using these substances against Helicobacter pylori infection to prevent gastric cancer. For this, PubMed and Science Direct databases were searched for studies that reported the activity of flavonoids against H. pylori, published within a 10-year time frame (2010 to August 2020). It resulted in 1,773 publications, of which 44 were selected according to the search criteria. The plant family primarily found in publications was Fabaceae (9.61%). Among the flavonoids identified after extraction, the most prevalent were quercetin (19.61%), catechin (13.72), epicatechin (11.76), and rutin (11.76). The potential mechanisms associated with anti-H. pylori activity to the extracts were: inhibition of urease, damage to genetic material, inhibition of protein synthesis, and adhesion of the microorganism to host cells.Conclusion: Plant extracts rich in flavonoids with anti-H. pylori potential proved to be a promising alternative therapy source, reinforcing the relevance of studies with natural products.

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“…In our previous studies, WRPE has been shown to improve allergic dermatitis, skin aging, and especially ischemic stroke via its antioxidant and anti-inflammatory properties [ 21 , 22 , 23 , 24 ]. Therefore, we extended the activity of WRPE to excitotoxic brain injury, in which oxidative and inflammatory processes play an important role.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, we reported that white rose petal extract (WRPE) displayed a broad spectrum of antioxidant [ 21 ], anti-bacterial and anti-fungal [ 22 ], anti-allergic, and anti-inflammatory properties [ 23 ]. Notably, a butanol fraction of WRPE containing high amounts of gallic acid and volatile compounds reduced the infarction volume in an animal model of ischemic cerebral stroke [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

The Ethanol Fraction of White Rose Petal Extract Abrogates Excitotoxicity-Induced Neuronal Damage In Vivo and In Vitro through Inhibition of Oxidative Stress and Proinflammation

2018

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Since oxidative stress and inflammation are involved in seizure-related neurotoxicity, the neuroprotective effect of a white rose (Rosa hybrida) petal extract (WRPE) in mice that are challenged with kainic acid (KA) were examined using behavioral epileptiform seizures as well as biochemical and morphological parameters of oxidative stress and inflammation. WRPE (50–200 mg/kg) was orally administered to male ICR mice for 15 days, and intraperitoneally challenged with KA (30 mg/kg). Seizure activity, lipid peroxidation, inflammatory cytokines, and related enzymes were analyzed in the brain tissue, in addition to the morphological alterations in the hippocampal pyramidal neurons. Separately, antioxidant ingredients in WRPE were analyzed, and antioxidant, anti-inflammatory, and neuroprotective activities of WRPE were investigated in HB1.F3 human neural stem cells (NSCs) to elucidate underlying mechanisms. Total polyphenol and flavonoid contents in WRPE were 303.3 ± 15.3 mg gallic acid equivalent/g extract and 18.5 ± 2.2 mg catechin/g extract, respectively. WRPE exhibited strong radical-scavenging activities and inhibited lipid peroxidation in vitro, and protected glutamate-induced cytotoxicity in NSCs by suppressing inflammatory process. Treatment with WRPE attenuated epileptiform seizure scores to a half level in KA-challenged mice, and decreased hippocampal pyramidal neuronal injury and loss (cresyl violet and DAPI staining) as well as astrocyte activation (GFAP immunostaining). Lipid peroxidation was inhibited, and mRNA expression of antioxidant enzymes (GPx, PHGPx, SOD1, and SOD2) were recovered in the brain tissues. Inflammatory parameters (cytokines and enzymes) including NF-kB, IL-1β, TNF-α, IL-6, HMGB1, TGF-β, iNOS, COX2, and GFAP mRNAs and proteins were also down-regulated by WRPE treatment. Taken together, the results indicate that WRPE could attenuate KA-induced brain injury through antioxidative and anti-inflammatory activities.

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Antimicrobial activities of ethanol and butanol fractions of white rose petal extract

Cited by 17 publications

References 39 publications

Production of Verbascoside, Isoverbascoside and Phenolic Acids in Callus, Suspension, and Bioreactor Cultures of Verbena officinalis and Biological Properties of Biomass Extracts

Production of Verbascoside, Isoverbascoside and Phenolic Acids in Callus, Suspension, and Bioreactor Cultures of Verbena officinalis and Biological Properties of Biomass Extracts

Flavonoids-Rich Plant Extracts Against Helicobacter pylori Infection as Prevention to Gastric Cancer

The Ethanol Fraction of White Rose Petal Extract Abrogates Excitotoxicity-Induced Neuronal Damage In Vivo and In Vitro through Inhibition of Oxidative Stress and Proinflammation

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