Antimicrobial activities of Eugenol and Cinnamaldehyde against the human gastric pathogen Helicobacter pylori

Ali, S. Mahaboob; Khan, Aleem Ahmed; Ahmed, Irshad; Musaddiq, M.; Ahmed, Khaja S.; Polasa, H.; Rao, L. Venkateswar; Habibullah, C. M.; Sechi, Leonardo Antonio; Ahmed, Niyaz

doi:10.1186/1476-0711-4-20

Cited by 239 publications

(115 citation statements)

References 28 publications

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“…It has been shown that cinnamaldehyde is effective against a variety of bacteria, viruses and fungi. 60 Cinnamaldehyde exhibited the MIC values of 0.1–0.5 μg/mL against E. coli (0.1 μg/mL), B. subtilis (0.5 μg/mL) and MRSA (0.25 μg/mL). Cinnamaldehyde inhibited the GTPase activity thus inhibiting the assembly of FtsZ protofilaments.…”

Section: Ftsz Inhibitorsmentioning

confidence: 97%

Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ

Haranahalli

Tong

Ojima

2016

Bioorganic & Medicinal Chemistry

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With the emergence of multidrug-resistant bacterial strains, there is a dire need for new drug targets for antibacterial drug discovery and development. Filamentous temperature sensitive protein Z (FtsZ), is a GTP-dependent prokaryotic cell division protein, sharing less than 10% sequence identity with the eukaryotic cell division protein, tubulin. FtsZ forms a dynamic Z-ring in the middle of the cell, leading to septation and subsequent cell division. Inhibition of the Z-ring blocks cell division, thus making FtsZ a highly attractive target. Various groups have been working on natural products and synthetic small molecules as inhibitors of FtsZ. This review summarizes the recent advances in the development of FtsZ inhibtors, focusing on those in the last 5 years, but also includes significant findings in previous years.

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Section: Ftsz Inhibitorsmentioning

confidence: 97%

Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ

Haranahalli

Tong

Ojima

2016

Bioorganic & Medicinal Chemistry

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“…14,15 Common medicinal plants used by local populations include Ocimum gratissimum , whose essential oil and main constituent eugenol displays anthelmintic and antimicrobial activities, 16,17 and Lippia sidoides , which is rich in the general antiseptic thymol. 18 …”

Section: Introductionmentioning

confidence: 99%

Thymol and eugenol derivatives as potential antileishmanial agents

Morais¹,

Vila-Nova²,

Beviláqua³

et al. 2014

Bioorganic & Medicinal Chemistry

100

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In Northeastern Brazil visceral leishmaniasis is endemic with lethal cases among humans and dogs. Treatment is toxic and 5–10% of humans die despite treatment. The aim of this work was to survey natural active compounds to find new molecules with high activity and low toxicity against Leishmania infantum chagasi. The compounds thymol and eugenol were chosen to be starting compounds to synthesize acetyl and benzoyl derivatives and to test their antileishmanial activity in vitro and in vivo against L. i. chagasi. A screening assay using luciferase-expressing promastigotes was used to measure the growth inhibition of promastigotes, and an ELISA in situ was performed to evaluate the growth inhibition of amastigote. For the in vivo assay, thymol and eugenol derivatives were given IP to BALB/c mice at 100 mg/kg/day for 30 days. The thymol derivatives demonstrated the greater activity than the eugenol derivatives, and benzoyl- thymol was the best inhibitor (8.67 ± 0.28 μg/mL). All compounds demonstrated similar activity against amastigotes, and acetyl-thymol was more active than thymol and the positive control drug amphotericin B. Immunohistochemistry demonstrated the presence of Leishmania amastigote only in the spleen but not the liver of mice treated with acetyl-thymol. Thus, these synthesized derivatives demonstrated anti-leishmanial activity both in vitro and in vivo. These may constitute useful compounds to generate new agents for treatment of leishmaniasis.

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“…Further, H. pylori did not develop any resistance towards these compounds even after 10 passages grown at sub-inhibitory concentrations. These results indicate that eugenol and cinnamaldehyde may prevent H. pylori growth in vitro, without acquiring any resistance [133].…”

Section: Antimicrobial Activity: Mode Of Actionmentioning

confidence: 76%

“…The suggested mechanism of inhibition of energy generation is inhibition of glucose uptake or its utilization and effects on membrane permeability [89]. Ali et al [133] studied the antimicrobial activities of eugenol and cinnamaldehyde against the human gastric pathogen Helicobacter pylori [133]. Both eugenol and cinnamaldehyde inhibited the growth of all the 30 H. pylori strains tested, at a concentration of 2 mg/ml, at 9 and 12 h of incubation, respectively.…”

Section: Antimicrobial Activity: Mode Of Actionmentioning

confidence: 99%

Essential Oils and New Antimicrobial Strategies

Baby

George²

2008

New Strategies Combating Bacterial Infection

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Essential oils are complex mixtures of plant secondary metabolites, composed mostly of terpenoids. They show considerable structural diversity with even nitrogen-and sulfur-containing compounds as their constituents. In plant systems they act, according to the design, as defense compounds against microbes, herbivores and other ecological factors. Essential oils have applications as antimicrobials, food preservatives, flavours and cosmetics. They are also used in clinical applications and aromatherapy. This article describes new essential oil based antimicrobial strategies, particularly giving emphasis to essential oil constituents. A range of recent mechanistic studies of essential oil constituents is compiled. The mode of action of essential oils as antimicrobials, specific assay techniques and other recent developments in these areas are also addressed. Further, the evolution of research on essential oils, biosynthesis extraction techniques, chemical analysis, physical parameters, olfactory evaluation and other basic concepts are also described.

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Antimicrobial activities of Eugenol and Cinnamaldehyde against the human gastric pathogen Helicobacter pylori

Cited by 239 publications

References 28 publications

Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ

Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ

Thymol and eugenol derivatives as potential antileishmanial agents

Essential Oils and New Antimicrobial Strategies

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