Antimicrobial Activities of Some Synthetic Flavonoids

Ibrahim, Nazifi Saleh; Ahmed, Farediah

doi:10.9790/5736-07520106

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…For instance, (E)-1-(2-hydroxyphenyl)-3-(4-fluorophenyl)chalcones was shown to possess antibacterial activity against E. coli, B. pumilis and B subtilis and, antifungal activity against A. niger [20]. These findings on the potency, against various pathogens, of the synthesized chalcones are similar to the observations reported in the cited literatures, Apart from the reported effect of fluoro groups on biological activitiy, other reports suggested that the α,β-unsaturated carbonyl group in chalcones are responsible for their antimicrobial activity [21] and the presence of more than one electron withdrawing group on B-ring of the chalcone skeleton might reduce this observed antimicrobial activity [22].…”

Section: Antibacterial Evaluationsupporting

confidence: 89%

Synthesis, Characterization and Antibacterial Activities of New Fluorinated Chalcones

2019

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A series of five fluorinated chalcones (E)-3-(2′-ethoxyphenyl)-1-(4-Fluoro-2-hydroxyphenyl)prop-2-en-1-one (4), (E)-3-(3′,4′-diethoxyphenyl)-1-(4-fluoro-2-hydroxyl-phenyl)prop-2-en-1-one (5), (E)-3-(2′,3′-dihydrobenzofuran-5-yl)-1-(4-Fluoro-2-hydroxylphenyl)prop-2-en-1-one (6), (E)-3-(3′,5′-Bis[trifluoromethyl]phenyl)-1-(4-Fluoro-2-hydroxylphenyl)prop-2-en-1-one (7) and (E)-3-(4′-diethylaminophenyl)-1-(4-Fluoro-2-hydroxylphenyl)prop-2-en-1-one (8) were synthesized by a modified Claisen-Schmidt condensation of 4-fluoro-2-hydroxyacetophenone with the appropriate aromatic aldehydes. The compounds were characterized by spectroscopic methods and evaluated for their antibacterial activity against Gram-positive (Methicillin-resistant S. aureus, Vancomycin-resistant enterococci, S. aureus, S. pyrogenes, S. faecalis) and Gram-negative (E. coli, S. typhi, C. ulcerans, P. mirabilis, P. aeruginosa) pathogenic bacteria strains using the agar diffusion method. The compounds exhibited broad spectrum activity against eight of these pathogens with compounds (4), (5) and (8) found to be the most potent in the series with zones of inhibition ranging from 23 to 28 mm and MIC between 25 and 50 µg/mL. All the compounds except (7) containing 3-(3′,5′-bis[trifluoromethyl]phenyl) moiety, showed a remarkable activity against MRSA [MIC = 25-50 µg/mL]. Compound (8) exhibited good activity against P. aeruginosa [MIC = 50 µg/mL]. Compounds (4), (5) and (8) were active against C. ulcerans [MIC = 50 µg/mL]. The broad-spectrum standard drug, ciprofloxacin, was inactive against MRSA, P. aeruginosa and C. ulcerans.

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Section: Antibacterial Evaluationsupporting

confidence: 89%

Synthesis, Characterization and Antibacterial Activities of New Fluorinated Chalcones

2019

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“…A series of heteroatom‐substituted chalcones have been successfully synthesized and characterized by spectral studies (Ibrahim and Ahmed ). All the synthesized compounds were evaluated for their antimicrobial activities against Bacillus cereus , E. faecalis , K. pneumoniae , Pseudomonas aeroginosa , Aspergillus fumigatus and C. glabrata .…”

Section: Chalconesmentioning

confidence: 99%

Synthetic flavonoids with antimicrobial activity: a review

et al. 2019

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The emergence of drug-resistant microbes left us with a great need for new antimicrobial agents. Flavonoids, with their wide range of biological activities, are good candidates in this respect. Although naturally occurring flavonoids are the most studied ones, semi-synthetic or synthetic flavonoids have proven to have great potential, inhibiting and even killing microbes at concentrations below 1 lg ml À1 . The substitution pattern of these flavonoids often includes hydroxy groups, halogens or other heteroatomic rings, such as pyridine, piperidine or 1,3-dithiolium cations. However, the great variety in substituents makes it difficult to draw any definitive conclusion regarding their structureactivity relationship.

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“…1 Antibiotics are the most frequently prescribed drugs in Intensive Care Unit. 2 One of the important aspects of effective treatment of lifethreatening infections leading to sepsis and septic shock is prescription of appropriate antimicrobial therapy.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic resistance pattern in intensive care unit of a tertiary care teaching hospital

Bhatia

Kalra

Kohli

et al. 2018

Int J Basic Clin Pharmacol

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Background: Antimicrobials are a major class of drugs prescribed in Intensive Care Unit (ICU). Widespread use of empirical antibiotic therapy has facilitated the emergence of drug resistance, since empirical therapy is very often initiated at the outset, even before culture and sensitivity reports are available. The problem of drug resistance is on a rise, therefore, this study was planned to assess the drug resistance and sensitivity patterns of the blood isolates recovered from ICU.Methods: An observational- prospective study was conducted in the Tertiary care teaching hospital over a period of twelve months to assess antibiotic resistance and sensitivity pattern. A total of 104 consecutive patients receiving antibiotics in the ICU and having blood cultures with significant growth were included in the study. Blood sample was collected and after obtaining a culture growth, the identification and antimicrobial sensitivity testing was done.Results: Blood stream infection by Gram-negative bacteria (50.96%) was more common than Gram-positive bacteria (49.04%). Coagulase negative Staphylococci (CoNS) was the predominant single blood culture isolate (35.58%). Klebsiella pneumoniae (13.46%), Escherichia coli (12.50%), Acinetobacter baumannii complex (7.69%) were commonly isolated gram negative organisms. Gram positive isolates were resistant to beta lactams in maximum patients whereas Tigecycline, Linezolid, Daptomycin, Vancomycin, Nitrofurantoin and Teicoplanin were sensitive against them. Common gram negative isolates were sensitive to Colistin and Tigecycline but resistant to most of the antibiotics.Conclusions: A preponderance of gram negative bacteria over gram positive bacteria was noted with a higher degree of resistance to most of the first line antimicrobial agents.

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Antimicrobial Activities of Some Synthetic Flavonoids

Cited by 5 publications

References 15 publications

Synthesis, Characterization and Antibacterial Activities of New Fluorinated Chalcones

Synthesis, Characterization and Antibacterial Activities of New Fluorinated Chalcones

Synthetic flavonoids with antimicrobial activity: a review

Antibiotic resistance pattern in intensive care unit of a tertiary care teaching hospital

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