Antimicrobial activity and antibiotic susceptibility of<i>Lactobacillus</i>and<i>Bifidobacterium</i>spp. intended for use as starter and probiotic cultures

Georgieva, Ralitsa; Yocheva, Lyubomira; Tserovska, Lilia; Zhelezova, Galina; Стефанова, Н. К.; Atanasova, Akseniya; Danguleva, Antonia; Ivanova, G A; Karapetkov, N.; Rumyan, Nevenka; Karaivanova, E.

doi:10.1080/13102818.2014.987450

Cited by 176 publications

(116 citation statements)

References 29 publications

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“…Probiotics CFS could also contain bacteriocins that are involved in their antimicrobial activity, in particular subtilosin by Bacillus subtilis prevents biofilm formation by inhibiting bacterial quorum sensing [27]. L. acidophilus is already known for its antimicrobial activity against S. aureus and E. coli [28], but the antibiofilm property has been demonstrated only in co-culture with S. aureus [29]. Unlike S. boulardii, the antimicrobial effects of L. acidophilus, L. lactis, L. casei and L. reuteri, mediated by direct cell competitive exclusion, as well as the production of acids or bacteriocin-like inhibitors against S. aureus, are already extensively studied [30].…”

Section: Discussionmentioning

confidence: 99%

Antibiofilm and Antiadhesive Activities of Different Synbiotics

Stefania¹,

Mir²,

Diana³

et al. 2017

J Prob Health

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Synbiotics are a combination of probiotic bacteria and the growth promoting prebiotic ingredients that purport "synergism".Probiotics are well known for their ability to restore a healthful balance of commensal microbes supporting the repair of hyper-permeable epithelial barriers and interfering with infection. The present research was designed to evaluate the anti-virulence role of cell-free supernatants of synbiotic cultures.The effect of prebiotics fructo-oligosaccharide, inulin and isomaltose on probiotic Lactobacillus acidophilus, Lactococcus lactis, Lactobacillus casei, Lactobacillus reuteri and Saccharomyces boulardii growth, fermentation products has been investigated. Cell-free supernatants of synbiotics cultures have been studied for their antimicrobial, antibiofilm and anti-adhesion properties. Results highlight that prebiotics can enhance the antimicrobial and anti-virulence activities of probiotics against potential pathogens Staphylococcus aureus and Escherichia coli.The present research supports, for the first time, the value of anti-virulence activity of metabolites produced by synbiotics suggesting their use as a suitable adjuvant in antibacterial treatment.

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Section: Discussionmentioning

confidence: 99%

Antibiofilm and Antiadhesive Activities of Different Synbiotics

Stefania¹,

Mir²,

Diana³

et al. 2017

J Prob Health

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“…The human health benefits of a large amount of Bifidobacterium have already been amply documented (Georgieva et al, 2015;Gueimonde, Sánchez, De Los Reyes-Gavilán, & Margolles, 2013). Therefore, the decreases experienced in mice exposed to ampicillin and sulphadiazine reflect changes that are detrimental to the host.…”

Section: Daymentioning

confidence: 99%

Low-dosage antibiotic intake can disturb gut microbiota in mice

Roca-Saavedra

Rodríguez

Lamas

et al. 2018

CyTA - Journal of Food

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2018)Low-dosage antibiotic intake can disturb gut microbiota in mice, CyTA -Journal of Food, 16:1, 672-678, ABSTRACT The proportion of different microbial populations in gut microbiota (GM) is an important factor that in recent years has been linked to obesity and numerous metabolic diseases. Antibiotics are one of the factors that can dramatically alter GM at therapeutic dosages, but their effects at subtherapeutic doses have been less investigated. Here, a mouse model using a total of 60 C57BL/6J mice was used to compare the evolution of total microbiota, four phyla and two genera considered as probiotics in control mice, and mice exposed to 50 µg/kg of ampicillin, 100 µg/kg of tetracycline or 100 µg/kg of sulphadiazine. The results obtained found that the presence of antibiotics in foods, even at trace concentrations, can disturb mouse GM, causing in all antibiotics significant increases of Proteobacteria (about 2 log CFU/g) or decreases of Bifidobacterium and Lactobacillus (about 1 log CFU/g) for the cases of ampicillin and sulphadiazine.La ingesta de bajas dosis de antibióticos es capaz de alterar la microbiota intestinal en ratones RESUMEN La composición de las diferentes poblaciones microbianas presentes en la microbiota intestinal humana es un aspecto importante que en los últimos años ha sido relacionada tanto con la obesidad con como muchas patologías metabólicas. Los antibióticos son uno de los agentes que pueden alterar de manera radical la composición de la microbiota intestinal cuando se utilizan a dosis terapéuticas, pero sus efectos a dosis sub-terapéuticas han sido menos investigados. Para este fin, se ha realizado un ensayo empleando 60 ratones C57BL/6J para comparar la evolución de la microbiota total, así como 4 filos y 2 géneros bacterianos beneficiosos en ratones control, ratones expuestos a 50 µg/kg de ampicilina, ratones expuestos a 100 µg/kg de tetraciclina y ratones expuestos a 100 µg/kg de sulfadiacina. Los resultados obtenidos mostraron que la presencia de antibióticos en los alimentos, incluso a concentraciones traza, pueden alterar la microbiota intestinal de los ratones, causando todos los antibióticos un incremento significativo de Proteobacteria (aproximadamente 2 log ufc/g), o descensos en los géneros Bifidobacterium y Lactobacillus (aproximadamente 1 log ufc/g) en los casos de la ampicilina y la sulfadiacina. ARTICLE HISTORY

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“…Several lactobacilli species are considered probiotic and their inhibitory properties on C. albicans have been studied, including Lactobacillus crispatus, Lactobacillus brevis, Lactobacillus rhamnosus and Lactobacillus plantarum. These lactic acid bacteria have different inhibitory mechanisms and may act through only one mechanism of inhibition or several at the same time (FAO/WHO 2002;Francavilla et al 2012;Georgieva et al 2015).…”

Section: Introductionmentioning

confidence: 99%