Antimicrobial activity and cytotoxicity of Zanthoxylum budrunga

Islam, Anwarul; Sayeed, Abu; Bhuiyan, M. Shah Alam; Mosaddik, Ashik; Islam, M. S.; Khan, Gul Roz

doi:10.1016/s0367-326x(00)00336-1

Cited by 30 publications

(22 citation statements)

References 5 publications

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“…The stem bark extracts of Enantia chloranta showed antimicrobial activity against some bacteria 4 . The antibacterial and antifungal activities of Zanthoxylum budrungia has been reported 5 . The use of chemotherapeutic agents in the treatment of infectious diseases has been known from time immemorial.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening and antimicrobial assessment of <i>Abutilon mauritianum, Bacopa monnifera and Datura stramonium</i>

Banso¹,

Adeyemo²

2010

Biokemistri

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Three medicinal plants -Abutilon mauritianum, Bacopa monnifera and Datura stramonium were assessed for phytochemical components and antimicrobial activity. The results revealed that all the three plant extracts contained saponins, tannins and alkaloids. Only Datura stramonium contained glycosides. The plants exert varying inhibitory effects on Pseudomonas aeruginosa, Klebsiella pneumonia and Escherichia coli. The minimum inhibitory concentration of the plant extracts ranged between 10% (w/v) (Bacopa monnifera) and 25% (w/v) (A. mauritianum and D. stramonium). Extracts of Abutilon mauritianum, Bacopa monnifera and Datura stramonium could be potential sources of chemotherapeutic agents.

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Section: Introductionmentioning

confidence: 99%

Phytochemical screening and antimicrobial assessment of <i>Abutilon mauritianum, Bacopa monnifera and Datura stramonium</i>

Banso¹,

Adeyemo²

2010

Biokemistri

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“…Islam et al (2001) verified that etheric extracts from the bark of Z. rhesta are toxic to Artemia salina which, on the other hand, does not suffer toxic action from chlorophormic extracts of Z. budrunga; Ju et al (2001) showed that Z. americanum presented substances, as dipetaline, alloxanthoxyletin e sesamin, that inhibit the DNA synthesis in HL-60 cells; Rodrigues et al (1998) reported the hexane extracts of Z. naranjillo induced alterations in albumin and alkaline phosphatase levels in mice, without liver or biliary alterations, which suggests a possible absence of clinical toxicity. From these studies, it is possible to confirm several potential therapeutical uses of plants from the genus Zanthoxylum.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves

2007

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Zanthoxylum rhoifolium Lam is a plant popularly used as antimicrobial, for malaria and inflammatory treatment. The essential oil of Z. rhoifolium was extracted and its cytotoxic effects against HeLa (human cervical carcinoma), A-549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), Vero (monkey kidney) cell lines and mice macrophages were evaluated. Some of the terpenes of its essential oil (β-caryophyllene, α-humulene, α-pinene, myrcene and linalool) were also tested to verify their possible influence in the oil cytotoxic activity. The results obtained permitted to confirm that the essential oil is cytotoxic against tumoral cells (CD 50 = 82.3, 90.7 and 113.6 µg/ml for A-549, HeLa e HT-29 cell lines, respectively), while it did not show cytotoxicity against non-tumoral cells (Vero and mice macrophages). Thus, the essential oil from Z. rhoifolium leaves seems to present a possible therapeuthic role due to its selective cytotoxic activity against tumoral cell lines. KEYWORDSZanthoxylum, Essential oil, cytotoxicity, β-caryophyllene, α-humulene Avaliação citotóxica do óleo volátil extraído das folhas do

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“…[2] [3] Genes for resistance to antibiotics, like the antibiotics themselves, are ancient. [4] However, the increasing prevalence of antibiotic-resistant bacterial infections seen in clinical practice stems from antibiotic use both within human medicine and veterinary medicine.…”

Section: Figure 1: Bacterial Resistance Mechanism On Antibioticsmentioning

confidence: 99%