Antimicrobial Activity of 4-Hydroxybenzoic Acid andtrans4-Hydroxycinnamic Acid Isolated and Identified from Rice Hull

Cho, Jeong Yong; Moon, Jae Hak; Seong, Ki-Young; Park, Keun Hyung

doi:10.1271/bbb.62.2273

Cited by 212 publications

(115 citation statements)

References 16 publications

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“…Since AHUP had IC 50 values ranging from 300 to 400 µg/mL, it was surmised that trans-p-coumaric acid in the alkaline hydrolysates was the main contributor to the antibacterial activity. Since hydroxycinnamic acids have been shown to exert antibacterial effects, 15,16) the presence of these compounds in the AHUP explains their antibacterial capability.…”

Section: Fig 2 Antimicrobial Effects Of Alkaline Hydrolysate Of Umementioning

confidence: 99%

Antimicrobial Activity of the Phenolic Compounds of Prunus mume against Enterobacteria

Mitani

Ota

Inaba

et al. 2018

Biological & Pharmaceutical Bulletin

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Mume fruit, the Japanese apricot (Prunus mume SIEB. et ZUCC.), is popular in Japan and is mostly consumed in the pickled form called umeboshi. This fruit is known to have anti-microbial properties, but the principal constituents responsible for the antimicrobial properties have not yet been elucidated. We investigated the antimicrobial activities of the phenolic compounds in P. mume against enterobacteria. In this study, growth inhibitory activities were measured as an index of the antibacterial activities. The phenolic compounds were prepared from a byproduct of umeboshi called umesu or umezu (often translated as "mume vinegar"). Umesu or umezu phenolics (UP) contain approximately 20% phenolic compounds with p-coumaric acid as a standard and do not contain citric acid. We observed the inhibitory effects of UP against the growth of some enterobacteria, at a relatively high concentration (1250-5000 µg/mL). Alkali hydrolysates of UP (AHUP) exhibited similar antibacterial activities, but at much lower concentrations of 37.5-300 µg/mL. Since AHUP comprises hydroxycinnamic acids such as caffeic acid, p-coumaric acid, and ferulic acid, the antibacterial activities of each of these acids were examined. Our study shows that the phenolic compounds in P. mume other than citric acid contribute to its antimicrobial activity against enterobacteria in the digestive tract.

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Section: Fig 2 Antimicrobial Effects Of Alkaline Hydrolysate Of Umementioning

confidence: 99%

Antimicrobial Activity of the Phenolic Compounds of Prunus mume against Enterobacteria

Mitani

Ota

Inaba

et al. 2018

Biological & Pharmaceutical Bulletin

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“…By comparison of their spectral data ( 1 H-, 13 C-NMR and MS) with that reported in the literature, compounds 1-5 and 7-10 were identified as 3-caffeoylquinic acid (1) [4], methyl 4-caffeoylquinic acid (2) [5], methyl 5-caffeoylquinic acid (3) [6], 4-hydroxybenzoic acid (4) [7], syringin (5) [8], amarantholidoside II (7) [9], (-)-oplopan-4-one-10- The spectral data all suggested that 6 was a nerolidol type sesquiterpene glycoside [9]. This was confirmed by the enzymatic hydrolysis of 6, which afforded 6a and a sugar component, which accounted for the last degree of unsaturation.…”

Section: Resultsmentioning

confidence: 90%

A New Sesquiterpene Glycoside from the Aerial Parts of Saussurea triangulata

et al. 2007

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“…In this study 4-HBA has a best paraciticidal activity after CA and FA in a comparison to other tested chemical agents. Cho et al (1998), showed the role of 4-HBA in rice hull that have antimicrobial effect against various microorganisms, most of the gram-positive and some gramnegative bacteria. A study by Chong et al, reported that the synergy effect of SA, CA and 4-HBA against Ganoderma boninense, either syringic with 4-HBA or caffeic with 4-HBA or syringic with CA or the combination of all the three phenolics totally inhibited the growth of Ganoderma Boninense, the pathogen failed to grow in a combination of a high concentration of all the three phenolics but the combination of lower concentration of the phenolics which poorly inhibited the growth of the pathogen, but a better performance were shown in a combination of CA and 4-HBA in a high concentration (Chong et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Herbal extract targets in Leishmania tropica

Mohammad

Shammary

Mageed³

et al. 2014

J Parasit Dis

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The present study aims to investigate the effect of some herbal extract such as phenolic compounds on the viability of Leishmania tropica promastigotes in vitro. Four tested chemical agents (caffeic acid (CA), ferulic acid (FA), syringic acid (SA) and 4-hydroxybenzoic acid (4-HBA)) were used in this study. The viability of Leishmania tropica promastigotes was investigated under five different concentrations (10, 15, 20, 25 and 30 mg/ml) of each agent after (72 h). CA was the most active agent on the promastigotes viability after 72 h exposure to 30 mg/ml concentration so that the parasiticidal effect reach (53 9 10 4 ) promastigote/ml. FA is the second agent in parasiticidal effect that parasiticidal effect reach to (50 9 10 4 promastigote/ml) at a concentration (30 mg/ml), 4-HBA is the third agent in parasiticidal effect that reach to (48 9 10 4 promastigote/ml) at a concentration (30 mg/ml), SA is the weakest agent in parasiticidal activity that reach to (44 9 10 4 promastigote/ml) at a concentration (30 mg/ml). It can be concluded that (CA, FA, SA and 4-HBA) possess acidal effect on the Leishmania tropica promastigotes in vitro.

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Antimicrobial Activity of 4-Hydroxybenzoic Acid andtrans4-Hydroxycinnamic Acid Isolated and Identified from Rice Hull

Cited by 212 publications

References 16 publications

Antimicrobial Activity of the Phenolic Compounds of <i>Prunus mume</i> against Enterobacteria

Antimicrobial Activity of the Phenolic Compounds of <i>Prunus mume</i> against Enterobacteria

A New Sesquiterpene Glycoside from the Aerial Parts of Saussurea triangulata

Herbal extract targets in Leishmania tropica

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