Antimicrobial activity of Amazonian oils against Paenibacillus species

Santos, Roberto Christ Vianna; Alves, Camilla Filippi dos Santos; Schneider, Taiane; Lopes, Leonardo Quintana Soares; Aurich, Carlos; Giongo, Janice Luehring; Brandelli, Adriano; Vaucher, Rodrigo de Almeida

doi:10.1016/j.jip.2011.12.002

Cited by 59 publications

(41 citation statements)

References 23 publications

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“…However, DCM fraction caused the death of bees in the concentration of 7.4 mg/mL, resulting in a survival rate of approximately 70% after 15 days of observation. The extracts of S. buxifolia and copaiba oil showed no toxic effects after 15 and 10 days following the treatment, respectively, using the same method described in the present article (Santos et al, 2012;Boligon et al, 2013a). Brazil has a very rich biological diversity.…”

Section: Discussionsupporting

confidence: 51%

“…1). The spraying application method was performed according to Santos et al (2012). Petri dishes (150 × 15 mm) padded with absorbent filter paper on the inner bottom and with an extra lid of plastic mesh were used.…”

Section: Toxicity Assaymentioning

confidence: 99%

“…This disease causes the decline of the population. American foulbrood can also lead to the death of the colony (Genersch et al, 2005;Santos et al, 2012). The causative agent is Paenibacillus larvae (White), a gram positive and sporeforming bacterium that is distributed worldwide (Spivak and Reuter, 2001;Genersch et al, 2006).…”

mentioning

confidence: 99%

“…American foulbrood is considered a global threat to apiculture because the etiologic agent produces environmentally stable spores which are very virulent, and resistant to Antimicrobial activity and toxicity of B. thyrsoides heat, to desiccation, and to disinfectants (Genersch, 2010;Boligon et al, 2013a). Products derived from plants, such as propolis (Bastos et al, 2008;Mihai et al, 2012), essential oils (Albo et al, 2003;Santos et al, 2012); and extracts of Myrtus communis L., Eucalyptus dunnii (Maiden), Rosmarinus officinalis L., Zingiber officinale (Roscoe), Scutia buxifolia (Reissek), among other species (Flesar et al, 2010;Boligon et al, 2013a) were previously investigated and exhibited a growth-inhibitory effect against AFB. Buddleja is a genus with pan tropical distribution that occurs in South Asia, Africa, and America (Mahlke et al, 2009).…”

mentioning

confidence: 99%

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Potential Use of Buddleja Thyrsoides for the Control and Prevention of American Foulbrood Disease in Honey Bees

Boligon

Piana

Brum

et al. 2014

Journal of Apicultural Science

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a b s t r a c t Paenibacillus larvae is the causative agent of american foulbrood (afb), a severe disease that affects the larvae of the honeybees. the use of plant extracts are considered to be an alternative way of controlling the disease. in this study, the in vitro antimicrobial activity of buddleja thyrsoides lam. against the Paenibacillus species, including P. larvae, was evaluated. in mueller-hinton broth, the minimal inhibitory concentration (miC) was assessed using the microdilution method. all Paenibacillus species were sensitive to the crude extract and the fractions of b. thyrsoides. the ethyl acetate (ea) fraction showed a better result with miC values of 1.68 -3.36 mg/ml, followed by butanolic (bU) (miC = 2.18 -6.54 mg/ml), dichloromethane (dCm) (7.40 -14.80 mg/ml), and crude extract (Ce) (7.51 -16.90 mg/ml). the toxic effect of the Ce and fractions of b. thyrsoides against bees were also evaluated using the spraying application method with the same concentrations of miCs. bee mortality was evident in treatment with dCm fractions only, while Ce, ea, and bU extracts showed no toxic effects after 15 days of observation. furthermore, phenolic acids, tannins, and flavonoids were identified and quantified by highperformance liquid chromatography (hPlC), and may be partially responsible for the antimicrobial properties observed. these results show, for the first time, that b. thyrsoides might be a natural alternative for the prevention/control of afb.

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Section: Discussionsupporting

confidence: 51%

Section: Toxicity Assaymentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Potential Use of Buddleja Thyrsoides for the Control and Prevention of American Foulbrood Disease in Honey Bees

Boligon

Piana

Brum

et al. 2014

Journal of Apicultural Science

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“…Some anti-inflammatory drugs have already been tested on VHR, and the results remain controversial. Andiroba oil shows anti-inflammatory, wound healing, and antimicrobial actions, thus it could be of great application for a better VHR outcome as it could modulate systemic inflammatory response, avoid infections, and lead to a better wound healing outcome (Brito et al, 2001;Rodrigues et al, 2008;Brito et al, 2006;Santos et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Andiroba oil (Carapa guianensis) on ventral hernia repair

Yasojima

Costa²,

Houat³

et al. 2014

J. Med. Plants Res.

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In the Amazon rainforest region, Andiroba oil is an herbal oil that is widely used by the local population to treat several inflammatory diseases. The objective of this study was to test Andiroba oil as a mesh coating or by oral administration in a rat model of excisional abdominal wall defect as an alternative to modulate inflammatory response without impairing the ventral hernia repair. Thirty six animals were distributed into three groups (N=12). (1) In the control group (CONT), ventral hernia repair was done using polypropylene/polyglecaprone mesh. (2) In the Andiroba oil gavage group (AndG), animals were treated with the meshes and 0.63 ml/kg of Andiroba oil was given by oral administration for 7 days prior to the mesh placement. (3) In the Andiroba oil submersion group (AndS), animals were treated with meshes that were previously submersed in Andiroba oil. At the 7th, 14th, and 21st days, macroscopic and microscopic analyses were done. AndG had fewer adhesions, necrosis, and lymphocytes, as well as similar collagen fiber formation and fibrosis areas as CONT. AndS showed a higher number of macrophages, fibrosis area, and less collagen fiber formation. Oral administration of Andiroba oil modulated inflammatory response, reduced abdominal adhesion formation, and did not impair tissue healing.

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