Antimicrobial activity of autoclaved and non autoclaved copaiba oil on Listeria monocytogenes

Pieri, Fábio Alessandro; José, Raphaela Mansur; Galvão, Newton Nascentes; Nero, Luís Augusto; Moreira, Maria Aparecida Scatamburlo

doi:10.1590/s0103-84782010000800020

Cited by 16 publications

(20 citation statements)

References 15 publications

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“…These therapeutic effects are due to the presence of diterpenes and sesquiterpenes 12 , such as copalic acid and β-caryophyllene sesquiterpenes and α-copaene…”

Section: Officinaliis C Reticulata C Langsdorffii C Guyanensismentioning

confidence: 99%

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Martini

Scapini

Collaço

et al. 2016

Rev. Col. Bras. Cir.

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Objectives: to evaluate, histologically and macroscopically, the influence of Copaifera multijuga (Copaíba) oil-resin on the healing process of cutaneous wounds, comparing it with nitrofurazone. Methods: we divided 36 rats into three groups of 12 animals, according to the treatment to be administered. Group SL (control) received saline on the lesion; the Group OIL received topical treatment with Copaíba oil; and the Group NITRO was treated with Nitrofurazone. We inflicted a circular wound of 8mm in diameter on the back of each animal. We subdivided each of the three groups of 12 animals into three subgroups, according to treatment time and euthanasia (7, 14 and 21 days). All animals received the proposed treatment daily. We photographed the lesions for area measurement, as well as for evaluation of macroscopic aspects. We resected and stained the scars to quantify and qualify elastic fibers, collagen, degree of epithelization, neovascularization and inflammation. Results: although the saline solution provided a faster wound closure in its initial phase, after 14 days the wound size of the three groups tested was the same. Levels of inflammation and neovascularization were similar in all three groups. The amount of collagen and elastic fibers was higher in the Nitrofurazone and Copaíba oil groups. Conclusion: in male Wistar rats, Copaifera multijuga oil-resin positively influences the healing process, but it is less effective than nitrofurazone in healing by secondary intention.

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“…These therapeutic effects are due to the presence of diterpenes and sesquiterpenes 12 , such as copalic acid and β-caryophyllene sesquiterpenes and α-copaene…”

Section: Officinaliis C Reticulata C Langsdorffii C Guyanensismentioning

confidence: 99%

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Martini

Scapini

Collaço

et al. 2016

Rev. Col. Bras. Cir.

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“…Copaifera spp. constitute a rich and promising source for the discovery of novel biologically active compounds with potential use in preventative therapies and in the treatment of oral diseases (Pieri et al, 2010;Souza et al, 2011a, b). In this sense, the search for new antimicrobial substances from other sources (including plants) for incorporation into dental products has intensified.…”

Section: In Vivo Mn Assaymentioning

confidence: 99%

Assessment of the antibacterial, cytotoxic and mutagenic potential of the phenolic-rich hydroalcoholic extract from Copaifera trapezifolia Hayne leaves

Leandro

Moraes

Oliveira

et al. 2016

Journal of Medical Microbiology

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Copaifera trapezifolia Hayne occurs in the Atlantic Rainforest, which is considered one of the most important and endangered tropical forests on the planet. Although literature works have described many Copaifera spp., their biological activities remain little known. In the present study, we aimed to evaluate (1) the potential of the hydroalcoholic extract from C. trapezifolia leaves (CTE) to act against the causative agents of tooth decay and apical periodontitis and (2) the cytotoxicity and mutagenicity of CTE to ensure that it is safe for subsequent application. Concerning the tested bacteria, the MIC and the minimum bactericidal concentration of CTE varied between 100 and 400 µg ml À1 . The time-kill assay conducted at a CTE concentration of 100 µg ml À1 evidenced bactericidal activity against Porphyromonas gingivalis (ATCC 33277) and Peptostreptococcus micros (clinical isolate) within 72 h. CTE at 200 µg ml À1 inhibited Porphyromonas gingivalis and Peptostreptococcus micros biofilm formation by at least 50 %. A combination of CTE with chlorhexidine dichlorohydrate did not prompt any synergistic effects. The colony-forming assay conducted on V79 cells showed that CTE was cytotoxic at concentrations above 156 µg ml À1 . CTE exerted mutagenic effect on V79 cells, but the micronucleus test conducted on Swiss mice and the Ames test did not reveal any mutagenicity. Therefore, the use of standardized and safe extracts could be an important strategy to develop novel oral care products with antibacterial action. These extracts could also serve as a source of compounds for the discovery of new promising biomolecules.

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“…Propolis resin (GEBARA; LIMA; MAYER, 2002;NOGUEIRA et al, 2007;REZENDE;PIMENTA;VARGAS et al, 2004) and a number of natural oils have presented activity against different bacteria (BETONI et al, 2006;PIERI et al, 2010a;PIERI et al, 2010b;SANTOS et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Escherichia coli from mastitic milk by copaiba oil

et al. 2011

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O objetivo deste estudo foi avaliar o efeito antimicrobiano de dois diferentes óleos de copaíba sobre isolados de Escherichia coli obtidos de leite mastítico. O ensaio antimicrobiano foi realizado utilizando o teste de difusão em agar, testando três soluções: um controle negativo e duas soluções dos diferentes óleos de copaíba. O teste foi realizado com 27 isolados de E. coli. Oito isolados (29.63%) foram inibidos pela solução com óleo de C. langsdorffii e sete pela solução com óleo de C. officinalis. Os resultados do presente estudo sugerem o óleo de copaiba como uma potencial fonte de novos e seletivos agentes para o tratamento da mastite, após posteriores testes em modelos in vivo. Palavras-chave: Escherichia coli, mastite, óleo de copaíba, antimicrobiano DOI: 10.5433/1679 AbstractThe aim of this study was to evaluate the antimicrobial effect of two different copaiba oils against Escherichia coli obtained from mastitic milk. An antimicrobial assay was performed using an agar diffusion test, testing three solutions: a negative control and two solutions of different copaiba oils. This test was performed with 27 mastitic E. coli isolates. Eight isolates (29.63%) were inhibited by C. langsdorffii oil solution and seven by C. officinalis oil. The results of the present in vitro study suggest that copaiba oils may be potential sources of new and selective agents for the treatment of mastitis, pending further testing in in vivo models.

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Antimicrobial activity of autoclaved and non autoclaved copaiba oil on Listeria monocytogenes

Abstract: The aim of this study was to evaluate the antimicrobial effect of different copaiba oil concentrations against the growth of Listeria monocytogenes, and analyze differences in inhibition of

Cited by 16 publications

References 15 publications

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Assessment of the antibacterial, cytotoxic and mutagenic potential of the phenolic-rich hydroalcoholic extract from Copaifera trapezifolia Hayne leaves

Inhibition of Escherichia coli from mastitic milk by copaiba oil

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