Antimicrobial activity of Cassia alata

Khan, Muhammad Rafiullah; Kihara, Masaru; Omoloso, A.D.

doi:10.1016/s0367-326x(00)00335-x

Cited by 75 publications

(54 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This agrees with several reports in which similar observations were made (Ibrahim and Osman, 1995;Khan et al, 2001;Somchit et al, 2003;Makinde et al, 2007;Abubacker et al, 2008;Sule et al, 2011) even though some worked on flowers (Abubacker et al, 2008), while others evaluated the stem bark (Sule et al, 2011). The higher statistical significant difference in activity of the leaf extracts at higher doses when compared with Ketoconazole on Candida albican, Microsporum canis and Trichophyton mentagrophyte (p<0.05) could be attributable to the presence of some bioactive components in the extract.…”

Section: Discussionsupporting

confidence: 94%

“…The increasing development of drug resistance in human pathogens as well as the unwanted side effects of some commonly use antimicrobial agents prompted the search for newer agents with promising effectiveness and safety (Phongpaichit et al, 2004). Several reports have shown that Cassia alata contain antimicrobial substances (Fuzellier et al, 1982;Palanichamy and Nagarajan, 1990;Crockett et al, 1992;Caceres et al, 1993;Ibrahim and Osman, 1995;Khan et al, 2001;Somchit et al, 2003;Timothy et al, 2012) that may be responsible for its reported activity in bacterial and fungal infections.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antifungal Activity of Aqueous and Ethanolic Leaf Extracts of Cassia Alata Linn

Timothy¹

2012

J. App. Pharm. Sci.

View full text Add to dashboard Cite

Cassia alata Linn is an important medicinal plant as well as ornamental flowering plant. The leaf decoction of Cassia alata has been used to treat infectious diseases in north eastern Nigeria. This study was embarked upon so as to evaluate the safety and efficacy of Cassia alata in the management of fungal infectious diseases. The leaves of the plant were collected, dried and extracted using water and 95% ethanol. The extracts were used for evaluating antifungal activity against five clinical isolates of pathogenic fungi. The result of this study showed a dose dependent antifungal activity of both aqueous and ethanolic leaf extracts on the five selected clinical isolates of pathogenic fungi. The extracts inhibited the growth of Candida albicans, Microsporum canis and Trichophyton mentagrophyte better than the ketoconazole 200 mg used as a positive control (p<0.05). The minimum inhibitory concentration of the water leaf extract of Cassia alata for Candida albicans, Aspergillus niger, Penicillium notatum, Microsporium canis and Trichophyton mentagrophytes were 26.90 mg, 32.40 mg, 29.50 mg, 30.30 mg and 27.80 mg respectively, while that of ethanol leaf extract of Cassia alata for Candida albicans, Aspergillus niger, Penicillium notatum, Microsporium canis and Trichophyton mentagrophytes were 5.60 mg, 3.50 mg, 4.90 mg, 12.60 mg and 9.80 mg respectively. Cassia alata has been found to exhibit a greater antifungal activity against some human pathogenic fungi in this study and this has justified the traditional use of this plant in managing fungal diseases.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Antifungal Activity of Aqueous and Ethanolic Leaf Extracts of Cassia Alata Linn

Timothy¹

2012

J. App. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…To obtain these concentrations, 1 ml aliquots of the extracts at double strength concentrations (6,12,18,24,30,40, 50 and 200 mg/ml) were added to test tubes containing 1ml of nutrient broth for the bacteria and potato dextrose broth for the fungi. A loopful of the test organisms previously diluted to 0.5 McFarland turbidity standards for bacterial isolates and 106spores/ml for fungal isolates was introduced to the respective tubes.…”

Section: Determination Of Minimum Inhibitory Concentration and Minimum mentioning

confidence: 99%

“…In recent years, pharmaceutical companies have focused on developing drugs from natural products (Akinyemi, 2000). Plants still remain the most effective and cheapest alternative sources of drugs (Khan et al, 2001). Drug discovery must be a continuing process if effective chemotherapeutic agents against the rapidly increasing drug resistant bacteria and fungi are to be obtained.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Qualities of Senna Alata

Ehiowemwenguan¹,

Inetianbor²,

Yakubu³

2014

IOSRJPBS

View full text Add to dashboard Cite

“…The other uses of C. alata are as an antihelminthic, antibacterial, laxative, diuretic, for treatment of snakebites and uterine disorders (Kirtikar and Basu, 1975). Besides the leaf extract of this species has shown several pharmacological properties such as antimicrobial, antifungal (Khan et al, 2001), antiseptic (Esimone et al, 2008), anti-inflammatory, analgesic (Palanichamy and Nagarajan, 1990) and antihyperglycemic activities (Palanichamy et al, 1988). It contains therapeutic (Damodaran and Venkataraman, 1994) and anti-ageing activities (Pauly et al, 2002) also.…”

Section: Cassia Alata Lmentioning

confidence: 99%