Antimicrobial activity of clove oil and its potential in the treatment of vaginal candidiasis

Abstract

In the present study, we evaluated antimicrobial activity of clove oil against a range of fungal pathogens including that responsible for urogenital infection. Clove oil was found to possess strong antifungal activity against opportunistic fungal pathogens such as Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, etc. The oil was found to be extremely successful in the treatment of experimental murine vaginitis in model animals. On evaluating various formulations, topical administration of the liposomized clove oil was found to be most effective against treatment of vaginal candidiasis.

Evaluation of antifungal activity in essential oil of the Syzygium aromaticum (L.) by extraction, purification and analysis of its main component eugenol

“…HPLC analysis of clove oil and laboratory reagent (LR) grade eugenol (Oxford Chemicals, India) was done in isocratic mode by using Shimadu’s prominent HPLC system using a reverse phase C18 column [Phenomenex Luna, 5μ C18 (2) 100A (250×4.60 mm)], eluent: methanol/acetonitrile (70:30), UV detector: 254 nm, flow rate 0.5 ml/min, column temperature 40˚C. One hundred milligrams of EO was dissolved in 5 ml of mobile phase solvent and 20 µl was injected.…”

“…Ahmad et al (2) evaluated antimicrobial activity of clove oil against a range of fungal pathogens including the ones for urogenital infection. Clove oil was found to possess strong antifungal activity against opportunistic fungal pathogens such as Candida albicans , Cryptococcus neoformans and Aspergillus fumigatus .…”

Biofilm inhibition by Cymbopogon citratus and Syzygium aromaticum essential oils in the strains of Candida albicans

“…But essential oils have been used effectively against such infections since ancient times without side effects. Oils of Cymbopogon citratus and Syzygium aromaticum have been documented for their antifungal effects against oral and vaginal candidiasis under in vitro and in vivo studies and their specific anti-Candida activity against planktonic forms is well established (Knoblock et al, 1989;Abe et al, 2003;Ahmad et al, 2005;Khan and Ahmad, 2012). However, little is known about the spectrum of action of these oils against Candida biofilm cells.…”

Fabrication and Evaluation of Nanostructured Herbal Oil/Hydroxypropyl-β-Cyclodextrin/Polyvinylpyrrolidone Mats for Denture Stomatitis Prevention and Treatment

“…Some research studies have reported antifungal activity of clove oil and eugenol against several yeasts and fungi (10)(11)(12)(13). Clove oil and eugenol have also been evaluated as antifungal agents in animal models (14).…”