Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera

Marslin, Gregory; Selvakesavan, Rajendran K.; Franklin, Gregory; Sarmento, Bruno; Dias, Alberto Carlos Pires

doi:10.2147/ijn.s81271

Cited by 61 publications

(39 citation statements)

References 27 publications

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“…The ability of NPs to adsorb secondary metabolites (Kurepa et al, 2014) could be exploited for purification of precious compounds from plants via nanotrapping, if harnessed properly. Similarly, in vitro green synthesis of NPs using plant extracts can be further extended to develop high throughput tools to purify specific classes of compounds, as green synthesized NPs are often found as conjugates of secondary metabolites (Marslin et al, 2015). …”

Section: Resultsmentioning

confidence: 99%

Nanoparticles Alter Secondary Metabolism in Plants via ROS Burst

2017

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The particles within the size range of 1 and 100 nm are known as nanoparticles (NPs). NP-containing wastes released from household, industrial and medical products are emerging as a new threat to the environment. Plants, being fixed to the two major environmental sinks where NPs accumulate — namely water and soil, cannot escape the impact of nanopollution. Recent studies have shown that plant growth, development and physiology are significantly affected by NPs. But, the effect of NPs on plant secondary metabolism is still obscure. The induction of reactive oxygen species (ROS) following interactions with NPs has been observed consistently across plant species. Taking into account the existing link between ROS and secondary signaling messengers that lead to transcriptional regulation of secondary metabolism, in this perspective we put forward the argument that ROS induced in plants upon their interaction with NPs will likely interfere with plant secondary metabolism. As plant secondary metabolites play vital roles in plant performance, communication, and adaptation, a comprehensive understanding of plant secondary metabolism in response to NPs is an utmost priority.

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Section: Resultsmentioning

confidence: 99%

Nanoparticles Alter Secondary Metabolism in Plants via ROS Burst

2017

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“…UV-visible spectrophotometer monitors the formation of AgNPs with the color change. To analyze formation of AgNPs, samples were withdrawn with the help of pipette at different time intervals, that is, 5, 10, 15, 20, 30, and 60 minutes [18]. …”

Section: Methodsmentioning

confidence: 99%

Antioxidant and Antibacterial Potential of Silver Nanoparticles: Biogenic Synthesis Utilizing Apple Extract

Nagaich

Gulati

Chauhan

2016

Journal of Pharmaceutics

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The advancement of the biological production of nanoparticles using herbal extracts performs a significant role in nanotechnology discipline as it is green and does not engage harsh chemicals. The objective of the present investigation was to extract flavonoids in the mode of apple extract and synthesize its silver nanoparticles and ultimately nanoparticles loading into hydrogels. The presence of flavonoids in apple extract was characterized by preliminary testing like dil. ammonia test and confirmatory test by magnesium ribbon test. The synthesized silver nanoparticles were characterized using UV spectroscopy, particle size and surface morphology, and zeta potential. Silver nanoparticles loaded hydrogels were evaluated for physical appearance, pH, viscosity, spreadability, porosity, in vitro release, ex vivo permeation, and antibacterial (E. coli and S. aureus) and antioxidant studies (DPPH radical scavenging assay). Well dispersed silver nanoparticles below were observed in scanning electron microscope image. Hydrogels displayed in vitro release of 98.01% ± 0.37% up to 24 h and ex vivo permeation of 98.81 ± 0.24% up to 24 h. Hydrogel effectively inhibited the growth of both microorganism indicating good antibacterial properties. The value of percent radical inhibition was 75.16% ± 0.04 revealing its high antioxidant properties. As an outcome, it can be concluded that antioxidant and antiageing traits of flavonoids in apple extract plus biocidal feature of silver nanoparticles can be synergistically and successfully utilized in the form of hydrogel.

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“…Interestingly, other researchers have examined and optimized the effect of changing concentrations of silver ions on the morphologies and applications of nanoparticles. Specifically, concentration sets of (0.1, 0.5, 1, and 2 mM), (0.5, 1, 2 mM), (20, 50, 100 mM) and (1-5 mM) were used by several authors [18][19][20][21].…”

Section: Silver Ion Concentrationmentioning

confidence: 99%

“…The effects of changing the concentrations of plant extract have been studied extensively. Many researchers have found that the concentrations of plant extract affect largely the shape and size and hence the nanoparticles biological activities [13,14,18,19,21,26,27].…”

Section: Concentration Of Plants Metabolites Reducing Agentsmentioning

confidence: 99%

“…Generally, the reaction requires short periods as indicated by most of reviewed works. However, some researchers reported several days for a complete conversion of Ag + and stabilization of the nanoparticles [11,18]. Some researchers have monitored the SPR band by UV-vis spectrophotometer and reported noticeable enhancement over time [21,24].…”

Section: Effect Of Reaction Timementioning

confidence: 99%

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Green synthesis of silver nanoparticles mediated by traditionally used medicinal plants in Sudan

2019

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Sudan has a tremendous wealth flora due to its unique geographical location and diverse climate. Vast records of plants and plants' secondary metabolites are reported to possess redox capacity and can be exploited for the biosynthesis of nanoparticles. Plant-mediated synthesis of silver nanoparticles is preferred due to their availability and their various metabolites. The present review explores the potentiality and diversity of biological activities of silver nanoparticles that originated from the combination of silver and phyto-constituents of mostly traditionally used Sudanese medicinal and aromatic plants. The green synthesis methods of silver nanoparticles mediated by more than 45 traditionally used medicinal plants are critically reviewed. In addition, parameters that affect the synthesis of plant-mediated silver nanoparticles, their characterization techniques and various biological activities are summarized and discussed. Thus, the study of green synthesis of silver nanoparticles and its applications can be extended to involve vast plant diversity of Sudan.

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Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera

Cited by 61 publications

References 27 publications

Nanoparticles Alter Secondary Metabolism in Plants via ROS Burst

Nanoparticles Alter Secondary Metabolism in Plants via ROS Burst

Antioxidant and Antibacterial Potential of Silver Nanoparticles: Biogenic Synthesis Utilizing Apple Extract

Green synthesis of silver nanoparticles mediated by traditionally used medicinal plants in Sudan

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