Antimicrobial activity of Curcuma longa L. extract on periodontal pathogens

Abstract

Aim: The aim of this study was to evaluate the antimicrobial activity of Curcuma longa L. extract (CLE) on periodontal pathogens. Materials and Methods: Sixty patients were divided into three groups: Group I ( n = 20) patients treated with scaling and root planning (SRP) only, Group II ( n = 20) patients treated with SRP followed by subgingival irrigation with 1% CLE solution, and Group III ( n = 20) patients treated with SRP followed by subgingival irrigation with 0.2% chlorhexidine (CHX) solution. The clinical parameters (plaque index [PI], gingival index [GI] scores, probing pocket depths) were recorded at baseline, 4 weeks, and 8 weeks. The antimicrobial efficacy of 1% CLE and 0.2% CHX solutions against Porphyromonas gingivalis, Prevotella intermedia , and Aggregatibacter actinomycetemcomitans were evaluated by disk diffusion method. Results: There was no significant difference in the mean values of zone of inhibition exhibited by both CLE and CHX solutions. All the groups showed significant improvement in the clinical parameters when compared to baseline values. The improvement in the PI and GI scores in the CLE group was lesser than that in CHX group by the end of the study period. Conclusion: CLE possess antimicrobial efficacy against the common periodontopathic bacteria. However, further large-scale studies evaluating the substantivity of C. longa are required to support its beneficial use in the treatment of periodontal diseases.

Effects of curcumin gel on osteoclastogenic bone markers in experimental periodontitis and alveolar bone loss in wistar rats

“…While the use of systemic medicines against periodontal disease has been shown in several published research with various side effects. 29 Curcumin has been known worldwide for its many health benefits 30 and clinical use of Curcumin as a suitable adjunct in the treatment of periodontitis has been reported by many researchers 31 , 32 , 33 and several others. Therefore, the aim of the current study was to assess the impact of local application of curcumin gels in EPD in rat, depending on its different biological and medicinal properties 34 and to clarify the processes by which this natural plant product acts and compared it with chlorhexidine, the well-known antimicrobial drug.…”

“…These results are in conjunction with the curcumin characteristics against periodontitis and probing-depth reduction that several trials have outlined. 32 , 33 , 51 Curcumin may, therefore, be used for oral care and, in particular, for periodontitis due to its antimicrobial activity against periodontal bacteria. 39 It has a potent anti-inflammatory and antioxidant activity, 52 and also because of a it has lesser adverse effect than chlorhexidine drug.…”

Detection of Biological Activity of Curcuma longa Methanol Extract and Its Antibacterial effect on Staphylococcus aureus

“…Differences in the susceptibility of S. aureus might be due to the variances in the cell wall structure, physiology and metabolism (4). Jalaluddin et al (19) found that C. longa extract was effective on some periodontal pathogens; Porphyromonas gingivalis, Prevotella intermedia and Aggregatibacter actinomycetemcomitans. This indicates that there is at least one substance in C. longa that has antimicrobial effects on many bacterial species.…”

Oral nano‐curcumin on gingival inflammation in patients with gingivitis and mild periodontitis

“…This may be attributed to the low dosage of curcumin and the use of curcumin in the form of mouthwashes. Therefore, it is suggested that a higher dosage of curcumin be used to achieve better results (Chainani‐Wu, 2003; Gottumukkala, Sudarshan, & Mantena, 2014; Jalaluddin et al, 2019; Muglikar et al, 2013). In the current study water solubility, absorption in the gastrointestinal tract, and prolonged plasma half‐life were improved by the formulation of curcumin as nano‐curcumin capsule form.…”