Antimicrobial Activity of Five Herbal Extracts Against Multi Drug Resistant (MDR) Strains of Bacteria and Fungus of Clinical Origin

Abstract

Antimicrobial activities of the crude ethanolic extracts of five plants were screened against multidrug resistant (MDR) strains of Escherichia coli, Klebsiella pneumoniae and Candida albicans. ATCC strains of Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus bovis, Pseudimonas aeruginosa, Salmonella typhimurium, Escherichia coli, Klebsiella pneumoniae and Candida albicans were also tested. The strains that showed resistance against the maximum number of antibiotics tested were selected for an antibacterial assay. The MDR strains were sensitive to the antimicrobial activity of Acacia nilotica, Syzygium aromaticum and Cinnamum zeylanicum, whereas they exhibited strong resistance to the extracts of Terminalia arjuna and Eucalyptus globulus. Community-acquired infections showed higher sensitivity than the nosocomial infections against these extracts. The most potent antimicrobial plant was A. nilotica (MIC range 9.75-313µg/ml), whereas other crude plant extracts studied in this report were found to exhibit higher MIC values than A. nilotica against community acquired as well as nosocomial infection. This study concludes that A. nilotica, C. zeylanicum and S. aromaticum can be used against multidrug resistant microbes causing nosocomial and community acquired infections.

Chemical Composition and Antibacterial Potential of Artemisia arborescens L. Essential Oil

“…However, the discovery of new active natural components may generate innovative food preservation strategies. Many examples may be found for plant-derived substances useful as food additives, with a broad spectrum of aptitudes including antioxidant [7,21] and antimicrobial activities [5,27]. Those characteristics are due to a number of secondary metabolites that may be found in various parts of the plants, and a strong interest is currently addressed to their individuation and exploitation [8].…”

Electrospun Herbal Extract Derived Polymer Nanocomposites for Medical Applications

“…To avoid such problems plant extracts with antibacterial properties against multidrug-resistant (MDR) strains of bacteria are evaluated, such as Escherichia coli, Klebsiella pneumoniae and Candida albicans (13). In this study the antibacterial and antifungal activity of ethanolic extracts of Acacia nilotica, Terminalia arjuna, Eucalyptus globulus, Syzygium aromaticum and Cinnamomum zeylanicum against multi-drug resistant strains isolated from nosocomial and community acquired infections was investigated.…”

“…After filtration and evaporation of ethanol the extracts were oven dried at 60 °C. For experiments each extract was dissolved in ethanol to the desired concentration (14).…”

Subacute oral toxicity study of ethanolic leaves extracts of Strobilanthes crispus in rats

“…By the use of the rotary evaporator at 45 °C and reduced pressure, most of the ethanol solvent was removed and the concentrated S. crispus extract was obtained [14] . The crude extract was then dried in the oven at 60 °C until a constant weight was obtained [15] . The percentage yield was calculated.…”