Antimicrobial activity of <i>Curcuma xanthorrhiza</i> nanoemulsions on <i>Streptococcus mutans</i> biofilms

Cho, Mu Yeol; Kang, Si Mook; Lee, Eun Song; Kim, Baek Il

doi:10.1080/08927014.2020.1823376

Cited by 12 publications

(6 citation statements)

References 34 publications

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“…Furthermore, quantitative analysis of live/dead biomass and biofilm thickness based on the CLSM images showed that the live/dead ratio with nanoemulsion treatment was 50% less compared with control. It was also reported that nanoemulsions, which were prepared using sonication, are more suitable to be used as antibiofilm materials than emulsions without sonication [71]. These results indicate that C. xanthorrhiza extract can penetrate the S. mutans biofilm and kill that cell.…”

Section: Antibiofilmmentioning

confidence: 86%

“…Because the biofilm matrix can limit the penetration of antimicrobial agents, Cho et al [71] explored the nanoemulsion form of C. xanthorrhiza oil in order to facilitate the ease of penetration. The single species S. mutans biofilm model, which was treated with nanoemulsion of C. xanthorrhiza oil, showed higher dead cells compared with the live cells.…”

Section: Antibiofilmmentioning

confidence: 99%

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Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

Suniarti¹,

Puspitawati²,

Yanuar³

et al. 2022

Focus on Bacterial Biofilms

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Most common oral diseases are directly related to oral biofilm, a complex community of microorganisms inhibiting the oral cavity. Recent studies provide deeper knowledge on how free-floating bacteria form a structurally organized microecosystem and on its pathogenicity and its self-defense mechanisms; thus, creating an understanding of the challenges in eliminating oral biofilm and maintaining the balance of oral ecosystem. Chlorhexidine has been the standard oral antimicrobial agent for decades. However, studies showed that it is less effective against bacteria in the form of biofilm that leads to an ongoing search of another method to fight against biofilm, including the use of plant-derived compounds. Medicinal plants are known to contain secondary metabolites, which are not only important in protecting the plant from any harmful environment but also potential as antimicroorganism and antioral biofilm for humans. Curcuma xanthorrhiza Roxb., containing xanthorrhizol (XNT), an essential bioactive compound, is an Indonesian native medicinal plant proven to have antibacterial and antibiofilm activities by several in vitro studies. The understanding of biofilm formation, its resistance to common drugs, and the potential role of C. xanthorrhiza-derived compounds as antibacterial and antibiofilm may contribute to developing C. xanthorrhiza into the alternative weapon against oral biofilm-related diseases.

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Section: Antibiofilmmentioning

confidence: 86%

Section: Antibiofilmmentioning

confidence: 99%

Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

Suniarti¹,

Puspitawati²,

Yanuar³

et al. 2022

Focus on Bacterial Biofilms

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“…In recent years, antibacterial effects of traditional Chinese medicine have been confirmed and nano traditional Chinese medicine have shown to synergize with other ingredients to achieve the purpose of strong antibacterial, making the ancient medicine more widely used in the advanced nanometer way and be accepted internationally. In this section, nano curcumin (CUR), scutellaria baicalensis (SB) and Cinnamon will be introduced respectively [ [89] , [90] , [91] , [92] , [93] , [94] , [95] ].…”

Section: Nano-antibacterial Materialsmentioning

confidence: 99%

Recent advances on nanomaterials for antibacterial treatment of oral diseases

Chen¹,

Chu²,

Jiang³

et al. 2023

Materials Today Bio

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“…While C. xanthorrhiza has been investigated for its potential as a nanoemulsion. However, this study focuses on the use of polymers from temulawak as drug delivery [56]. Asam jawa (Tamarindus indica Linn), belonging to the family Fabaceae, is indigenous to tropical Africa but has become naturalized in North and South America.…”

Section: Determination Of Mucoadhesive Herbal and Polyherbalmentioning

confidence: 99%

Determination of herbal combinations based on mucoadhesive properties

Lestari

Widyarti

Sumitro

2022

IOP Conf. Ser.: Earth Environ. Sci.

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Mucoadhesive properties of herbs are the herb’s ability to strongly interact or penetrate in binding to mucin components in the mucus. The oral preparation of polyherbal made for therapeutic purposes must have a mucoadhesive capability. This in vitro study aims to determine herbal combinations that have a potential stable interaction with MUC2. The screening of 10 herbal namely, a flower of tembelekan (Lantana camara), rosela (Hibiscus sabdariffa), and asam jawa (Tamarindus indica); rind of jeruk nipis (Citrus aurantifolia); leaf of sirih merah (Piper crocatum), kelor (Moringa oleifera), and meniran hijau (Phyllanthus niruri); rhizome of kencur (Kaempferia galanga), temulawak (Curcuma xanthorrhiza), and jahe (Zingiber officinale) based on the changes in MUC2 viscosity, interaction percentage and absorption percentage. Kencur, rosela, kelor, and meniran hijau maintains the viscosity. Therefore, the interaction process occurs without significantly changing the physicochemical properties of the mucin. While the other herbs, especially jeruk nipis, tembelekan dan asam jawa, caused an increased viscosity of MUC2. Kencur or temulawak can also reduce the possibility of asam jawa changing the viscosity of mucin. Based on these results, we recommend kencur-temulawak mix or kencur-asam jawa mix as a polyherbal because both have a positive interaction percentage value that indicates an additional percentage of precipitated mucin compared to pure mucin (MUC2).

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Antimicrobial activity of Curcuma xanthorrhiza nanoemulsions on Streptococcus mutans biofilms

Cited by 12 publications

References 34 publications

Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

Recent advances on nanomaterials for antibacterial treatment of oral diseases

Determination of herbal combinations based on mucoadhesive properties

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