Antimicrobial activity of impregnated antibiotic matrix materials for bone tissue defect reconstruction

Pantus, A. V.; Рожко, М. М.; Куцык, Р. В.; Козовый, Р. В.; MELNICHUK, Mykola V.

doi:10.31688/abmu.2020.55.1.02

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Polymer nanomaterials, films, and coatings are widely used in various industries, including pharmaceuticals and medicine. Polymer tapes and films are used in equipment construction as working elements [ 1 , 2 ], to ensure the tightness of threaded joints during the life cycle of the product [ 3 , 4 ], for elastic fixation of broken bones during surgery on human limbs [ 5 , 6 ], for filtering liquids and gases [ 7 , 8 ], for aqueous nanostructures containing antimicrobials of natural origin have been developed to inactivate SARS-CoV-2 surrogates on surfaces [ 9 ], for wound healing [ 10 , 11 , 12 ] and dentistry [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films

et al. 2022

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The prospects of using biopolymer nano-containing films for wound healing were substantiated. The main components of biopolymer composites are gelatin, polyvinyl alcohol, glycerin, lactic acid, distilled water, and zinc oxide (ZnO) nanoparticles (NPs). Biopolymer composites were produced according to various technological parameters using a mould with a chrome coating. The therapeutic properties of biopolymer films were evaluated by measuring the diameter of the protective effect. Physico-mechanical properties were studied: elasticity, vapour permeability, degradation time, and swelling. To study the influence of technological parameters of the formation process of therapeutic biopolymer nanofilled films on their therapeutic and physico-mechanical properties, the planning of the experiment was used. According to the results of the experiments, mathematical models of the second-order were built. The optimal values of technological parameters of the process are determined, which provide biopolymer nanofilled films with maximum healing ability (diameter of protective action) and sufficiently high physical and mechanical properties: elasticity, vapour permeability, degradation time and swelling. The research results showed that the healing properties of biopolymer films mainly depend on the content of ZnO NPs. Degradation of these biopolymer films provides dosed drug delivery to the affected area. The products of destruction are carbon dioxide, water, and a small amount of ZnO in the bound state, which indicates the environmental safety of the developed biopolymer film.

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Section: Introductionmentioning

confidence: 99%

Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films

et al. 2022

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The influence of thyroid pathology on the course of periodontal disease in children and ways to correct it (Review)

Kitsak

2021

MTT

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Iodine deficiency diseases constitute an important medical and social problem, since a significant part of the territory of Ukraine is characterized by biogeochemical indicators of low iodine content in the environment, which is the cause of hypothyroidism development. At the same time, there are many other factors that can trigger the thyroid disorders in children. Epidemiological studies carried out in the Carpathian region have shown that iodine deficiency of varying degrees is specific to this area. Professor M.M. Kovalev's in-depth study of the causes of goitre in Bukovyna showed that along with iodine deficiency, macro- and micronutrient deficiencies associated with certain regions play an important role. Iodine deficiency promotes goitrogenesis and decreases the secretory capacity of the thyroid gland. As a result of reduced intrathyroid iodine in the gland, diiodothyrosine synthesis decreases and monoiodothyrosine increases, the hormone ratio increases due to an increase in the more biologically active triiodothyronine. This compensates for the euthyroid state against the background iodine deficiency. An adaptive manifestation of iodine deficiency is goitre, considered being the main sign of iodine deficiency; as iodine deficiency or thyroid hormone requirements increase, goiter size increases and more severe forms of thyroopathology develop. Iodine deficiency is common in many countries of the world. The analysis of the research data has shown the multifactorial nature of the etiology and pathogenesis of periodontal diseases in children, as well as the significant impact of thyroid disorders on the condition of the human dentition. In this regard, the study of cause-effect relationships between the initial manifestations of thyroid pathology and periodontal tissue changes in children seems relevant and promising in terms of improving methods of diagnosis, prevention and treatment. Keywords: periodontium, diffuse non-toxic goitre, children.

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Antimicrobial activity of impregnated antibiotic matrix materials for bone tissue defect reconstruction

Cited by 2 publications

References 11 publications

Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films

Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films

The influence of thyroid pathology on the course of periodontal disease in children and ways to correct it (Review)

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