Antimicrobial activity of lectins from Antimicrobial Activity of Lectins from Plants

Karnchanatat, Aphichart

doi:10.5772/33456

Cited by 9 publications

(6 citation statements)

References 132 publications

(169 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, lectins isolated from Talisia esculenta seeds showed antifungal effect on Fusarium oxysporum, Colectrotrichum lindemuthianum, and Saccharomyces cerevisiae (Maria das Graças et al, 2002). Two novel chitin binding seeds of Artocarpus integrifolia demonstrated growth inhibition of Fusarium moniliforme and Saccharomyces cerevisae (Karnchanatat, 2012). Apart from the direct effect of lectins on fungal growth, lectin genes also impart protection in transgenic plants from fungal infection.…”

Section: Anti -Fungal Action Of Lectinsmentioning

confidence: 99%

Structure-function and application of plant lectins in disease biology and immunity

Mishra

Behura

Mawatwal

et al. 2019

Food and Chemical Toxicology

154

View full text Add to dashboard Cite

A B S T R A C TLectins are proteins with a high degree of stereospecificity to recognize various sugar structures and form reversible linkages upon interaction with glyco-conjugate complexes. These are abundantly found in plants, animals and many other species and are known to agglutinate various blood groups of erythrocytes. Further, due to the unique carbohydrate recognition property, lectins have been extensively used in many biological functions that make use of protein-carbohydrate recognition like detection, isolation and characterization of glycoconjugates, histochemistry of cells and tissues, tumor cell recognition and many more. In this review, we have summarized the immunomodulatory effects of plant lectins and their effects against diseases, including antimicrobial action. We found that many plant lectins mediate its microbicidal activity by triggering host immune responses that result in the release of several cytokines followed by activation of effector mechanism. Moreover, certain lectins also enhance the phagocytic activity of macrophages during microbial infections. Lectins along with heat killed microbes can act as vaccine to provide long term protection from deadly microbes. Hence, lectin based therapy can be used as a better substitute to fight microbial diseases efficiently in future.

show abstract

Section: Anti -Fungal Action Of Lectinsmentioning

confidence: 99%

Structure-function and application of plant lectins in disease biology and immunity

Mishra

Behura

Mawatwal

et al. 2019

Food and Chemical Toxicology

154

View full text Add to dashboard Cite

show abstract

“…The families of lectins include the legume, chitin-binding, mannose-binding, and jacalin-related lectins, which do not share a common structure but rather differ in structures, sizes, molecular organization, and active sites although having the same activity of binding to carbohydrates promoting antibacterial effects [ 159 ]. Their mechanism of action is through the interaction with bacterial cellular wall components including peptidoglycans, lipopolysaccharides (LPS), teichoic, and teichuronic acids [ 182 , 183 , 184 ]. When they interact with bacteria, lectins affect their adherence and therefore interferes with biofilm formation (as well as planktonic growth).…”

Section: Use Of Bioactive Compounds As Antibiofilm Agentsmentioning

confidence: 99%

Mechanisms and Impact of Biofilms and Targeting of Biofilms Using Bioactive Compounds—A Review

et al. 2021

View full text Add to dashboard Cite

Biofilms comprising aggregates of microorganisms or multicellular communities have been a major issue as they cause resistance against antimicrobial agents and biofouling. To date, numerous biofilm-forming microorganisms have been identified, which have been shown to result in major effects including biofouling and biofilm-related infections. Quorum sensing (which describes the cell communication within biofilms) plays a vital role in the regulation of biofilm formation and its virulence. As such, elucidating the various mechanisms responsible for biofilm resistance (including quorum sensing) will assist in developing strategies to inhibit and control the formation of biofilms in nature. Employing biological control measures (such as the use of bioactive compounds) in targeting biofilms is of great interest since they naturally possess antimicrobial activity among other favorable attributes and can also possibly act as potent antibiofilm agents. As an effort to re-establish the current notion and understanding of biofilms, the present review discuss the stages involved in biofilm formation, the factors contributing to its development, the effects of biofilms in various industries, and the use of various bioactive compounds and their strategies in biofilm inhibition.

show abstract

“…Furthermore, antibodies raised against PHA show reactivity with lectins from A. constricta , C. praecox and C. caladenia [ 6 ]. From these studies, it is clear that lectins have been conserved during the evolution of legumes and that the extensive homologies reflect taxonomical relationships among these plants [ 51 ].…”

Section: Structure Of Legume Lectinsmentioning

confidence: 99%

“…Plant lectins often are present at potential sites of microbial invasion and their binding to fungal structures led to the inhibition of fungal growth and germination. Studies carried out with soy bean and common lentil agglutinins provide evidence for these roles [ 51 , 82 , 83 , 84 ]. A main characteristic of lectins is their ability to interact with glyco-components present on the cell membrane surface, in cytoplasmic and nuclear structures and in the extracellular matrix of cells and tissues from almost all kingdoms of life [ 85 ].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…Lectins of Triticum vulgare , Dolichos lablab L., Trigonella foenumgraecum , Trifolium alexandrium L., Bauhinia variegata L. and Delonix regia have shown antimicrobial activity against Mycobacterium rhodochrous , Bacillus cereus , B. megaterium , B. sphaericus , Escherichia coli , Serratia marcescens , Corynebacterium xerosis and Staphylococcus aureus [ 86 ] Lectins from the Vicieae tribe strongly react with the bacterial cell wall components, muramic acid, N -acetylmuramic acid and muramyl dipeptides [ 87 ]. Nevertheless, although legume seed lectins can recognize and bind to the constituents of the bacterial cell wall, such binding does not imply that these interactions occur in vivo, and certainly does not prove that these lectins are involved in the protection of seedlings against bacteria [ 51 ].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

See 1 more Smart Citation

Legume Lectins: Proteins with Diverse Applications

Lagarda-Díaz

Guzmán-Partida

Vázquez–Moreno

2017

IJMS

140

View full text Add to dashboard Cite

Lectins are a diverse class of proteins distributed extensively in nature. Among these proteins; legume lectins display a variety of interesting features including antimicrobial; insecticidal and antitumor activities. Because lectins recognize and bind to specific glycoconjugates present on the surface of cells and intracellular structures; they can serve as potential target molecules for developing practical applications in the fields of food; agriculture; health and pharmaceutical research. This review presents the current knowledge of the main structural characteristics of legume lectins and the relationship of structure to the exhibited specificities; provides an overview of their particular antimicrobial; insecticidal and antitumor biological activities and describes possible applications based on the pattern of recognized glyco-targets.

show abstract

Antimicrobial activity of lectins from Antimicrobial Activity of Lectins from Plants

Cited by 9 publications

References 132 publications

Structure-function and application of plant lectins in disease biology and immunity

Structure-function and application of plant lectins in disease biology and immunity

Mechanisms and Impact of Biofilms and Targeting of Biofilms Using Bioactive Compounds—A Review

Legume Lectins: Proteins with Diverse Applications

Contact Info

Product

Resources

About