Antimicrobial Activity of Lipoprotein Particles Containing Apolipoprotein Al

Tada, Norio; Sakamoto, Takuya; Kagami, Akihiko; Mochizuki, Kazuki; Kurosaka, Kösei

doi:10.1007/978-1-4615-3078-7_23

Cited by 17 publications

(15 citation statements)

References 34 publications

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“…Studies conducted in Oncorhynchus mykiss (Rainbow trout) have confirmed the expression of apoA-I in some of the most important epithelial and mucosal layers [13]. HDL and apoA-I have also been demonstrated to have antimicrobial properties [12,194] inhibiting the growth of Escherichia coli and Staphylococcus epidermidis [173,195], a finding largely attributable to apoA-I. Another innate immune related role of apoA-I which was also discovered in fish is its regulation of the complement system [11].…”

Section: Other Roles In the Innate Immune Response Antiviral Andmentioning

confidence: 91%

High Density Lipoprotein: Assembly, Structure, Cargo, and Functions

Murphy

2013

ISRN Physiology

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Cardiovascular disease (CVD) is the leading cause of death globally. For close to four decades, we have known that high density lipoprotein (HDL) levels are inversely correlated with the risk of CVD. HDL is a complex particle that consists of proteins, phospholipids, and cholesterol and has the ability to carry micro-RNAs. HDL is constantly undergoing remodelling throughout its life-span and carries out many functions. This review summarizes many of the different aspects of HDL from its assembly, the receptors it interacts with, along with the functions it performs and how it can be altered in disease. While HDL is a key cholesterol efflux particle, this review highlights the many other important functions of HDL in the innate immune system and details the potential therapeutic uses of HDL outside of CVD.

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Section: Other Roles In the Innate Immune Response Antiviral Andmentioning

confidence: 91%

High Density Lipoprotein: Assembly, Structure, Cargo, and Functions

Murphy

2013

ISRN Physiology

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“…HDL displays anti-parasitic functions by virtue of a subset of its particles carrying a parasite-specific lysosomal pore-forming protein (15), and HDL demonstrates anti-apoptotic and anti-oxidant activities by its ability to directly influence intracellular signaling cascades or to deliver anti-oxidant proteins such as paraoxonase 1, which stimulates the ERK1/2 and PI3K signaling pathways (16 -18). Furthermore, apolipoprotein A1 (apoA1), the major structural protein of HDL, when either expressed or injected in vivo, spontaneously lipidates forming HDL and demonstrates a number of innate immune activities, including the following: (i) antiviral effects for both enveloped and nonenveloped DNA and RNA viruses (19,20); (ii) antiparasitic activity as mentioned above; (iii) both bacteriocidal and bacteriostatic effects (21); and (iv) modulatory effects on regulatory T cells (22). Potent bacterial toxin neutralizing activities of HDL are attributed primarily to apoA1, which binds and neutralizes both bacterial endotoxin and lipoteichoic acid (23,24).…”

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confidence: 99%

The Cardioprotective Protein Apolipoprotein A1 Promotes Potent Anti-tumorigenic Effects

Zamanian-Daryoush

Lindner²,

Tallant

et al. 2013

Journal of Biological Chemistry

215

262

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Background: ApoA1, a component of HDL, promotes anti-inflammatory, immunomodulatory, and cardioprotective functions. Results: ApoA1 suppresses tumor growth and metastasis, primarily via modulation of innate and adaptive immune responses. Conclusion: ApoA1 impacts tumor biology at multiple levels, which appear to be linked to immunomodulatory function. Significance: ApoA1 redirects elicited immune cells toward tumor suppression and rejection and may hold benefit as a cancer therapeutic.

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“…No homologous protein has been noted for apo-14 kDa from Japanese eel, pufferfish, and orange-spotted grouper, naming apo-14 kDa for fishspecific apolipoprotein [20,21,23]. Some studies have revealed that apoA-I and apo-14 kDa in fish plasma HDLs were associated with innate immune system [24][25][26][27], whereas mammalian HDLs containing apoA-I and apoA-II possessed antimicrobial or antiviral activities in vitro [15,[28][29][30][31]. Apo-14 kDa has also been reported to be required for digestive system organogenesis during embryogenesis and early larval development of gibel carp [32].…”

Section: Introductionmentioning

confidence: 99%