Antimicrobial Activity of Mineral Trioxide Aggregate and Calcium Hydroxide Sealer on Enterococcus Faecalis Strain Atcc29212

Prathita, Tara; Djauharie, Nila Kesuma; Meidyawati, Ratna

doi:10.22159/ijap.2019.v11s1.ar178

Cited by 7 publications

(9 citation statements)

References 22 publications

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“…Most of the studies investigated the antimicrobial efficacy of MTA Fillapex. Nineteen studies used planktonic cells [16,33,34,38,45,46,48,50,52–62] while four studies used either young biofilms [38,49] or mature biofilms [37,40].…”

Section: Resultsmentioning

confidence: 99%

“…The most commonly used antimicrobial test was the agar diffusion test (ADT) [33,34,38,45,48,50,52,53,59–61]. Nine studies used the direct contact test (DCT) [16,36,40,46,50,56–58,62], where colony forming units (CFUs) were counted. Two studies [54,55] used DCT readings of optical density (OD).…”

Section: Resultsmentioning

confidence: 99%

“…Only one study [37] used confocal laser scanning microscopy (CLSM) to investigate antimicrobial efficacy. Antibacterial efficacy was studied in 19 studies [16,33,34,36–38,40,46,50,52,53,55–62]. The results of these studies are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Two of the included studies [34,35] were available as an abstract only- therefore, assessment of their reporting quality was not possible. The remaining studies provided clear descriptions of models and sample size [10,16,27,33,36–42,45,46,52,56–58,60–62,65]. All studies adequately reported the sealers used in the study.…”

Section: Resultsmentioning

confidence: 99%

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Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review

et al. 2019

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BackgroundRecently, a new generation of bioceramic root canal sealers has been introduced onto the market. Many in vitro studies have investigated the antimicrobial properties of these sealers, but their comparative efficacy in antimicrobial activity is still unknown.MethodologyThree electronic databases were searched: MEDLINE and Embase via the OvidSP platform, and Web of Science, up to June 25, 2019. Studies were included irrespective of study design, type of publication and language. Reporting quality was assessed by two authors independently. Meta-analysis was not performed due to studies being highly heterogeneous.ResultsWe included 37 studies that analysed the antimicrobial effects of bioceramic sealers. Most of them used a planktonic cell model, with the exception of nine studies which used biofilms. It was not possible to make direct comparison of results from studies and to give a clear conclusion about the comparative antimicrobial activity of these materials because the studies used heterogeneous sources and ages of microorganisms, setting and contact times of sealers, and antimicrobial tests. Furthermore, some materials showed completely different results when tested with different methods.ConclusionsIn conclusion, multiple in vitro studies have shown that bioceramic sealers may have various degrees of antimicrobial activity. However, it is still impossible to make conclusions about their comparative efficacy and to recommend the use of one over another in clinical practice because the studies available were conducted in different ways, which makes meta-analysis futile. A uniform methodological approach, consistent definitions and studies on humans are urgently needed in this field of research so that recommendations for practice can be made.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review

et al. 2019

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“…Among the various nanomaterials so far developed, dendrimers show a huge potential as an excellent nanocarrier owing to their well-defined, globular, highly branched and controllable nanostructural features, which are unique to them and the terminal groups present can be functionalized with different ligands having multivalency similar to the chemical groups present in different biological systems [53]. In addition to being explored as promising carriers of chemical drugs, therapeutic nucleic acids, proteins and peptides, they are also functional as macromolecular contrast agents and biosensor platforms for CNS therapies, imaging, and diagnosis [54]. All these possibilities offered by dendrimers upraise them to be smart nanocarriers in the future endeavors in drug delivery systems [55].…”

Section: Drug-related Factorsmentioning

confidence: 99%

An Updated Review on the Application of Dendrimers as Successful Nanocarriers for Brain Delivery of Therapeutic Moieties

et al. 2021

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It’s been nearly 100 y of effort to study the organization and role of the blood brain-barrier and still, we strive to find better techniques to overcome this barrier to deliver the drugs to the brain effectively with reduced systemic side effects. The advances in nanotechnology have given newer horizons in achieving this goal since the nano-scaled systems can modify an existing drug to have a high degree of sensitivity to the physiological conditions and specificity to reach the target organ. Among the various nanocarriers, dendrimers owing to their unique physical and chemical characteristics, represent a potential therapeutic tool in biomedical and pharmaceutical science. Dendrimers, an established polymeric nanocarrier system of the time, can deliver both drugs and genetic material and are being extensively studied to target the brain. The surface modification of dendrimers can reduce their innate toxicity problems and increase the therapeutic efficacy of brain disorders. This review article is an attempt to update on the potential of dendrimers explored in the past five years as a drug delivery avenue that can be considered as a promising solution in the management of a wide range of disorders affecting the central nervous system, including neoplastic, degenerative, and ischemic conditions. The following search criteria were used to expand the review article with the keywords dendrimers, novel drug delivery, nanoparticles, site-specific drug delivery etc.

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Biological properties of lithium-containing surface pre-reacted glass fillers as direct pulp-capping cements

et al. 2022

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Antimicrobial Activity of Mineral Trioxide Aggregate and Calcium Hydroxide Sealer on Enterococcus Faecalis Strain Atcc29212

Cited by 7 publications

References 22 publications

Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review

Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review

An Updated Review on the Application of Dendrimers as Successful Nanocarriers for Brain Delivery of Therapeutic Moieties

Biological properties of lithium-containing surface pre-reacted glass fillers as direct pulp-capping cements

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