Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review

Abstract

BackgroundRecently, a new generation of bioceramic root canal sealers has been introduced onto the market. Many in vitro studies have investigated the antimicrobial properties of these sealers, but their comparative efficacy in antimicrobial activity is still unknown.MethodologyThree electronic databases were searched: MEDLINE and Embase via the OvidSP platform, and Web of Science, up to June 25, 2019. Studies were included irrespective of study design, type of publication and language. Reporting quality was assessed by two authors independently. Meta-analysis was not performed due to studies being highly heterogeneous.ResultsWe included 37 studies that analysed the antimicrobial effects of bioceramic sealers. Most of them used a planktonic cell model, with the exception of nine studies which used biofilms. It was not possible to make direct comparison of results from studies and to give a clear conclusion about the comparative antimicrobial activity of these materials because the studies used heterogeneous sources and ages of microorganisms, setting and contact times of sealers, and antimicrobial tests. Furthermore, some materials showed completely different results when tested with different methods.ConclusionsIn conclusion, multiple in vitro studies have shown that bioceramic sealers may have various degrees of antimicrobial activity. However, it is still impossible to make conclusions about their comparative efficacy and to recommend the use of one over another in clinical practice because the studies available were conducted in different ways, which makes meta-analysis futile. A uniform methodological approach, consistent definitions and studies on humans are urgently needed in this field of research so that recommendations for practice can be made.

Antibacterial activity, cytocompatibility and effect of Bio‐C Temp bioceramic intracanal medicament on osteoblast biology

“…2013, Šimundić Munitić et al . 2019), a biofilm aged 48 h was tested, because this period is sufficient to distinguish among the intracanal medicaments. Moreover, in relation to biofilm, it should be borne in mind that monospecies biofilms do not mimic the clinical situation as well as multispecies biofilm (Hoedke et al .…”

“…Laboratory studies have reported varying degrees of antimicrobial activity of bioceramic materials, precluding any conclusions to be drawn concerning its antimicrobial effectiveness (Šimundić Munitić et al . 2019). It is important to highlight that additional testing using a polymicrobial biofilm, dentine with a root canal geometry as a substrate (Swimberghe et al .…”

The Effect of Calcium-Silicate Cements on Reparative Dentinogenesis Following Direct Pulp Capping on Animal Models

“…Endodontic bioceramics are not influenced by humidity or blood contamination [ 73 , 74 ], are stable and insoluble over time, providing an adequate seal [ 75 ]. Before setting, bioceramics manifest an antibacterial effect, and afterwards, they become biocompatible and bioactive [ 76 ]. Among these bioceramic endodontic materials, we can mention BioAggregate (Innovative Bioceramix, Vancouver, BC, Canada), with a composition similar to that of MTA’s.…”

Impact of Warm Vertical Compaction on the Sealing Ability of Calcium Silicate-Based Sealers: A Confocal Microscopic Evaluation

“…According to the manufacturer, calcium silicate-based sealers such as Endosequence BC (Brasseler USA, Savannah, GA, USA) and iRoot SP (Innovative BioCeramix Inc., Vancouver, BC, Canada) are composed of calcium silicate, calcium phosphate, calcium hydroxide, zirconium oxide, and other agents [ 5 ]. They showed effective antimicrobial activity against multiple microorganisms [ 6 ]. Furthermore, they revealed a slight volume expansion while setting.…”