An Antibiotic is an infectious disease that is the chief source for treating bacterial & fungal infections. The microbial resistance problem has been increasing daily, and the viewpoint for the usage of antimicrobial drugs is still undefined. Antimicrobial-resistant organisms are found in people, animals, food, plants, and in the environment. Do not use antibiotics to treat viral infections like colds and flu. The leading mechanism for spreading the resistance of antibiotics over bacterial populace is plasmids. Biofilm formation decreases the penetration of antifungal compounds into the population. According to World Health Organization (WHO) medicinal plants would be the best source to attain a variety of drugs. 80% of people from developed countries use traditional medicine derived from medicinal plants. Using plant extracts and phytochemicals with identified antimicrobial properties can be greatly useful in treatments. Several plants rich in a wide variety of secondary metabolites, such as tannins, alkaloids, and flavonoids, have been used for their antimicrobial qualities. They can spread from person to person or between people and animals, including food of animal origin. Quick diagnostics are required for both pathogen identification and resistance testing.INTRODUCTION: An Antibiotic is an infectious disease that is the chief source for treating bacterial & fungal infections. For now, the findings of these antibiotics as chemo-therapeutic agents have led to the subsequent eradication of infectious diseases. The development of Escherichia coli, Klebsiella pneumoniae, Haemophilus, and may other βlactamase has become a main therapeutic problem. Multi-drug resistant strains of E. coli and K. pneumoniae are gradually being isolated from community-acquired infections. 50-70% cases have stated to account for invasive candidiasis.