Antimicrobial Activity of Moringa Oleifera Extracts against Common Periodontal Pathogens: Potential Application in the Prevention and Treatment of Oral Diseases

Nagarajappa, Ramesh; Bhanushali, Nikhil; Ramesh, Gayathri; Bhanushali, Parin V.; Aapaliya, Pankaj; Pujara, Piyush

doi:10.5958/0976-5506.2019.03467.3

Cited by 3 publications

(5 citation statements)

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“…Its role in periodontal disease progression is related to its virulence factor, such as gingipains, lipopolysaccharides, and pili which have immunomodulatory effects, furthermore resulting in dysbiosis of the periodontal microenvironment. 29 One of the ingredients in MO is MCP (moringa coagulant protein) which flocculates microorganisms through charge neutralization and adsorption. 29 Kaempferol, extracted from MO and a natural flavonoid, exhibits dose-dependent antimicrobial effect by disrupting bacterial cell membrane.…”

Section: Discussionmentioning

confidence: 99%

“… 29 One of the ingredients in MO is MCP (moringa coagulant protein) which flocculates microorganisms through charge neutralization and adsorption. 29 Kaempferol, extracted from MO and a natural flavonoid, exhibits dose-dependent antimicrobial effect by disrupting bacterial cell membrane. 30 Isoquercitrin, another active ingredient of MO, can decrease expression of viral, bacterial, and pathogenic orchestration by attenuating the activity of transcription factor such as NF-kB.…”

Section: Discussionmentioning

confidence: 99%

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Antiplaque Efficacy of a Novel Moringa oleifera Dentifrice: A Randomized Clinical Crossover Study

et al. 2022

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Objectives The use of herbal dentifrices has grown exponentially over the years. They are categorically referred to as ethnomedicines. Various agents have been tried with contradicting findings based on phytopharmacological analysis. Miswak is one agent which has been used over the years. A novel Moringa oleifera-based dentifrice has shown promising results in terms of its cytotoxicity, biocompatibility, and as a potent anti-inflammatory agent. Therefore, the present study aims to compare the efficacy of two commercially available miswak- and moringa-based herbal dentifrices on the reduction of plaque and gingivitis scores. Materials and Methods This randomized clinical crossover study included 20 subjects with mild to moderate gingivitis. The study was conducted over a total examination period of 20 days with a wash-out period of 2 weeks between the use of both the toothpastes. The plaque index and gingival index of the study subjects were recorded at the designated time intervals throughout the study period. Statistical Analysis The data collected were entered on Microsoft Excel, and statistical analysis using SPSS software (SPSS version 28, IBM Corp, Armonk, New York, United States) was done. The statistical test used was the Wilcoxon signed-rank test. Moreover, p ≤0.05 was considered significant. Results The results showed that the reduction in mean gingival index scores from baseline to day 3 was more statistically significant in the moringa-based dentifrice. Similarly, the plaque index scores showed statistically significant reduction following the use of the moringa-based dentifrice when compared with the miswak dentifrice. This study reveals that the moringa dentifrice is a safe and effective agent in reducing plaque accumulation and treating gingival inflammation. Conclusion The current study aims to provide an insight into the possible role of moringa dentifrice as a possible adjunctive oral hygiene aid.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antiplaque Efficacy of a Novel Moringa oleifera Dentifrice: A Randomized Clinical Crossover Study

et al. 2022

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“…M. oleifera leaf showed medicinal properties that improved human oral health care. MO leaf extract inhibited cariogenic biofilm formation and acted against oral pathogens including Staphylococcus aureus , Streptococcus mutans and Candida albicans [ 55 , 56 , 57 ], whereas CC showed significant results for anti-inflammatory and antimicrobial action on S. aureus [ 44 , 58 ]. This present study revealed that the GI from baseline to week 4 in smoker group III (MO + CC lozenges) significantly decreased, indicating that MO + CC lozenges reduced gum inflammation in smokers.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-Inflammatory Effect of Moringa oleifera Lam. and Cyanthillium cinereum (Less) H. Rob. Lozenges in Volunteer Smokers

Luetragoon

Sranujit

Noysang

et al. 2021

Plants

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Smokers have high plaque accumulation that initiates gingival inflammation and progresses to periodontitis. Thus, oral hygiene to control microbial plaque formation is an effective method of preventing gingivitis. Medicinal plants such as Moringa oleifera Lam. (MO) and Cyanthillium cinereum (Less.) H. Rob. (CC) have an anti-inflammatory effect that might improve oral health in smokers. This study evaluated the effect of MO leaf and CC extracts using MO lozenges and a combination of MO + CC lozenges on oral inflammation and gingivitis in volunteer smokers. Lozenges consisting of MO and CC extracts were developed and studied in vivo. The results showed that lozenges significantly reduced oral inflammation and gingivitis in volunteers. The gingival index (GI) of group III (MO + CC lozenges) significantly decreased, while the percentage decrease of oral inflammation in group II (MO lozenges) was significantly higher than the other groups. The percentage decrease of GI values in group II (MO lozenges) and group III (MO + CC lozenges) were significantly higher than the placebo group I. Our findings indicated that MO and MO + CC lozenges reduced oral inflammation and gingivitis and showed potential to improve oral health in smokers.

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“…Abd Rani et al (2018) reported that fatty acids like oleic acid, linoleic acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, arachidic acid, linolenic acid, behenic acid, and paullinic acid are present in M. oleifera. The seed oil (yield 30-40% wt/wt), also known as "Ben oil," is used for the production of biodiesel, because of the high content of monounsaturated fatty acids in the form of oleic acid (Saini et al, 2016) (Nagarajappa et al, 2019). Moreover, for dental remedies, experimental toothpaste exhibited more inhibition against Staphylococcus aureus, Streptococcus mutans than mouthwash.…”

Section: Nutritive Values Of Moringamentioning

confidence: 99%

“…It was suggested in the study that M. oleifera leaves may serve as potential candidates to prevent dental caries. Leaves and fruit extracts of Moringa oleifera were found to be effective with therapeutic potential against common periodontal pathogens like Porphyromonas gingivalis and Prevotella intermedia (Nagarajappa et al, 2019). Moreover, for dental remedies, experimental toothpaste exhibited more inhibition against Staphylococcus aureus , Streptococcus mutans than mouthwash.…”

Section: Bio‐efficacy Of M Oleifera For Oral Health Carementioning

confidence: 99%

Phytoperspective of Moringa oleifera for oral health care: An innovative ethnomedicinal approach

Mohanty

Bhuyan

et al. 2020

Phytotherapy Research

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The present era accentuate the use of alternative medicines as drugs extracted from several plant parts. These herbal medicines otherwise called ethnomedicines are now the source of many imperative drugs in this contemporary world. Furthermore with ever rising oral problems by luxurious lifestyle in this modern society, there is a soaring need for use of potent medicinal plants like horse radish (Moringa oleifera Lam.) against various oral ailments. Therefore, use of herbal medicines in reducing the adverse effects of various conventional allopathic medicines and harmful side effects of conventional antibiotics has emerged as an evolved technique in pharmaceutical science. The present review emphasizes the antipathogenic potentiality of M. oleifera along with their known therapeutic properties through biologically active compounds (phytoconstituents) and ethnomedicinal uses. Various ethno‐pharmacological studies of the plant parts with their nutritional value and multifarious medicinal uses including oral health care are being quoted in present review. This review will foster future research on phytoconstituent analysis, bioefficacy assessment for oral micro flora and ethno‐pharmaceutical importance of M. oleifera in the field of medical science with special reference to dentistry. Consequently, this innovative ethnomedicinal approach for oral health care may supplement the modern medicine through its potent phytoconstituents.

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Antimicrobial Activity of Moringa Oleifera Extracts against Common Periodontal Pathogens: Potential Application in the Prevention and Treatment of Oral Diseases

Cited by 3 publications

References 0 publications

Antiplaque Efficacy of a Novel Moringa oleifera Dentifrice: A Randomized Clinical Crossover Study

Antiplaque Efficacy of a Novel Moringa oleifera Dentifrice: A Randomized Clinical Crossover Study

Evaluation of Anti-Inflammatory Effect of Moringa oleifera Lam. and Cyanthillium cinereum (Less) H. Rob. Lozenges in Volunteer Smokers

Phytoperspective of Moringa oleifera for oral health care: An innovative ethnomedicinal approach

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