Antimicrobial activity of N,N'-dialkylpolymethylenediamines against some dental plaque bacteria

Abstract

Twenty N,N'-dialkylpolymethylendiamine derivatives were synthesized, and a study was made of their antimicrobial activities in vitro against four oral microorganisms which are related to dental caries. The maximum activity was shown by N,N'-dinonyl or N,N'-didecyl derivatives among the complete homologous series of compounds studied.

Antimicrobial and Anti-Plaque Activity of AT-Alkyl-M- (2-aminoethyl)piperidine against Dental Plaque Bacteria

“…naeslundii, the MICs against other microorganisms, and the growth termination time for S. mutans and S. sobrinus in their respective aqueous solutions were measured using the methods reported previously. 5 Measurement of Surface Tension-The surface tension of solutions containing various concentrations of test compounds was measured at 37 "C using a Face Surface Tensiometer CBVP-A3 (Kyowa Kaimenkagaku Company, Tokyo, Japan).…”

“…' We have previously reported on the in vitro anti-plaque effects of some antimicrobial agents that are active against microorganisms that play a n important role in the occurrence of dental caries. 5 In the present study, five homologues of N'-alkyl-N-(2-aminoethyl)piperidine were synthesized, and their in vitro antimicrobial and anti-plaque activities against these microorganisms were investigated.…”