Antimicrobial activity of naphthoquinones from Fusaria

Baker, Robert A.; Tatum, James H.; Nemec, S.

doi:10.1007/bf02277294

Cited by 64 publications

(32 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These were allowed to stay for three hours before incubating at 30°C for 24 h (Boonphong et al, 2001). The plates were examined after 48 h and the diameter zone of inhibition (DZ1) for each test organisms was recorded (Baker et al, 1990). (Table 3).…”

Section: Determination Of Antimicrobial Activity Of Actinomycetes Isomentioning

confidence: 99%

A survey of antibiotic-producing actinomycetes in the soil environment of Keffi metropolis, Nasarawa State, Nigeria

Makut¹,

Abdulazeez²

2012

J. Microbiol. Antimicrob.

View full text Add to dashboard Cite

The soil environment is a vast reservoir that harbours microorganisms that represent virtually all the microbial groups including actinomycetes. An investigation was carried out to determine the species of antibiotic-producing actinomycetes found in the soil environment of Keffi Metropolis, Nasarawa State, Nigeria. Soil samples were obtained from ten different locations of Keffi town for the isolation of actinomycetes. Eight species belonging to two genera were isolated from the soil samples and these include Actinomyces israelii, Actinomyces viscosus, Streptomyces antibioticus, Streptomyces aureofiens, Streptomyces caespitosus, Streptomyces exfoliatus, Streptomyces griseus and Streptomyces hygroscopicus. All except S. aureofiens were found to have antimicrobial activity against at least one of the four pathogenic organisms tested for sensitivity. The pathogenic organisms tested for sensitivity were Candida albicans, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The results of this investigation revealed that species of antibiotic-producing actinomycetes are found in the soil environment of Keffi Metropolis, and these could be harnessed for the industrial production of novel antibiotics.

show abstract

Section: Determination Of Antimicrobial Activity Of Actinomycetes Isomentioning

confidence: 99%

A survey of antibiotic-producing actinomycetes in the soil environment of Keffi metropolis, Nasarawa State, Nigeria

Makut¹,

Abdulazeez²

2012

J. Microbiol. Antimicrob.

View full text Add to dashboard Cite

show abstract

“…nHexane soluble fraction was obtained only in three strains which showed mild toxicity. Antimicrobial naphthoquinones are widely distributed in plants, fungi and some animals (Riffel et al, 2002) are also reported from F. solani (Ammar et al, 1979;Baker et al, 1990). Besides naphthoquinones, F. solani is also known to produce diterpene and paclitaxel (Chakravarthi et al, 2008), and has been used alone or in combination with other chemotherapeutic agents for the treatment of variety of cancers, as well as AIDS-related Kaposi sarcoma (Brown, 2003;Croom, 1995 Means of 3 replicates.…”

Section: Resultsmentioning

confidence: 99%

“…F. solani is known to produce naphthoquinone compounds (Baker et al, 1990) including fusarubin, anhydrofusarubin, javanicin, norjavanicin, methyl etherfusarubin, marticin, isomarticin, bostrycoidia, ethyl ether-fusarubin, solaniol, nectriafusarubin and dihydrofusarubin lactone (James & Robert 1983;Kurobane et al, 1980;Tatum et al, 1985). Some naphthaquinones have antimicrobial, toxic, insecticidal and antitumor properties (Ammar et al, 1979).…”

mentioning

confidence: 99%

Toxicity of <I>Fusarium solani</I> Strains on Brine Shrimp (<I>Artemia salina</I>)

Hameed¹,

Sultana²,

Ara³

et al. 2009

Zoological Research

View full text Add to dashboard Cite

Discovery of anticancer drugs that must kill or disable tumor cells in the presence of normal cells without undue toxicity is an extraordinary challenge. Cytotoxicity of plant or fungal materials is considered as the presence of antitumor compounds. Brine shrimp lethality for larvae (nauplii) is used as prescreening test for the antitumor compounds. In this study, culture filtrates of eight strains of Fusarium solani isolated from seeds of various crops were tested for the toxic effect on brine shrimp. Five of the strains (TS, S-29, B-17, C-10, W-5) showed highest toxic effect and three of the strains (SR, T-9, L-25) showed low toxic activity on brine shrimp. Toxic activity reduced when culture filtrates were diluted. However, F. solani strains TS, B-17, SR, T-9 and L-25 caused more than 30% mortality at 1:10 dilution. Toxic activity was slightly reduced when the filtrates were neutralized with sodium hydroxide indicating possible role of pH of culture filtrate on toxicity. Lyophilized filtrates of these strains showed less activity as compared to un-lyophilized filtrates. n-Hexane soluble fraction was obtained only in three strains which showed mild toxicity whereas chloroform soluble fraction was obtained in negligible quantity and could not further be proceeded. Toxic effect of these strains showed variation from strain to strain. Compounds from F. solani could be exploited for the development of toxic compounds. Pakistan; 3. Agricultural Biotechnology and Phytopathology Laboratory, Department of Botany, University of Karachi, Pakistan; 4. California Department of Food and Agriculture, 3288 Meadowview Road, Sacramento, CA 95832, USA) 摘要：寻找能杀伤肿瘤细胞而对正常细胞无毒的抗癌药物极具挑战性。具有细胞毒性的植物或者真菌可能含有抗肿瘤的化合物。卤虫无节幼体的致死性可作为筛选抗肿瘤化合物的试验。本研究运用从不同农作物种子分离的 8 株镰刀菌（Fusarium solani）培养滤液来测试卤虫的细胞毒性效果。结果表明，5 株菌株（TS、S-29、B-

show abstract

“…Secondary metabolites like fusarubin and its derivatives isolated from Fusarium sp. are also known for their antibacterial activity (Baker et al, 1990). The present study revealed that secondary metabolites isolated from F. oxysporum f. sp.…”

Section: Anti-nemic Activitymentioning

confidence: 93%