Antimicrobial activity of new 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol derivatives

Danilchenko, D. M.; Парченко, В. В.

doi:10.14739/2310-1210.2017.1.91735

Cited by 9 publications

(3 citation statements)

References 2 publications

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“…Numerous publications by various scientific teams from around the world have demonstrated the high reactivity of 1,2,4-triazole derivatives, as well as their low toxicity [6,10], and a wide range of possibilities for their use as potential biologically active compounds [7][8][9]. Promising properties of some 1,2,4-triazole derivatives, which are used as effective plant growth regulators, have been described in [8,11].…”

Section: Original Researchmentioning

confidence: 99%

Diuretic activity of some 4- and 3-thio-substituted 1,2,4-triazoles with fluorophenyl fragments

et al. 2023

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Diuretics increase the volume of urine and sodium excretion, and therefore are often used to remove excess fluid from the body during various diseases, including hypertension, heart and kidney failure, nephrotic syndrome, cirrhosis, etc. Until now, a wide range of diuretics is known, but none of them is completely safe and has a number of side effects. The aim of the work is to investigate the diuretic activity of 1,2,4-triazole derivatives containing fluorophenyl substituents at the fifth position of the 1,2,4-triazole fragment, as well as to establish the relationship between “chemical structure and diuretic action” among derivatives 1,2,4-triazole. Materials and methods. To study the effect on kidney function, six groups of animals with seven rats each were used. When studying water diuresis, rats were kept on a constant diet with free access to water. Before water loading (5 % of body weight), rats were fasted for 2 hours without food and water. Since all tested compounds were insoluble in water, they were administered orally as an aqueous suspension stabilized with Tween-80. The compounds were administered at a dose of 1/10 LD50. Results. The diuretic activity of 28 new compounds of a number of substituted 1,2,4-triazole-3-thiols, which according to their chemical structure belong to different classes of compounds, was investigated. Conclusions. Analysis of the results of diuretic activity indicates that there are a number of compounds whose activity is higher than hypothiazide, as well as a compound that exceeds the activity of furosemide.

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Section: Original Researchmentioning

confidence: 99%

Diuretic activity of some 4- and 3-thio-substituted 1,2,4-triazoles with fluorophenyl fragments

et al. 2023

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“…After 24 h of exposure, inactivation of the cultures of S. aureus 209P, E. coli K12, E. coli 195β, S. enteritidis occurred at concentrations of tetraazadigomodamantane not lower than 0,032%, 0,017%, 0,012% and 0,019%, respectively. The antimicrobial activity of the synthesized ilidenhydrazide compounds against S. aureus 209P, E. coli 675, S. disenteriae 1675 E, Proteus vulgaris 5, B. anthracis 1319, P. aeruginosa 165 detects antimicrobial activity, but does not exceed the activity of standard comparison (Danilchenko et al, 2017).…”

Section: Introductionmentioning

confidence: 96%

Determination of antimicrobial activity of some 1,2,4-triazole derivatives

Al-Rawashdeh

2018

Regul. Mech. Biosyst.

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We carried out MIC of the derivatives of 1,2,4-triazole II (4-((5-nitrofuran-2-yl)methyleneamino)-1-propyl-4H-1,2,4-triazolium bromide) and I (N-((5-nitrofuran-2-yl)methylene)-4H-4-amino-1,2,4-triazolidium chloride) against Escherichia coli ATCC 3912/4 and E. coli k88ad, Staphylococcus aureus ATCC 25923 and S. aureus k99, Klebsiella pneumonia k56 and Salmonella typhimurium 144, S. enteritidis. All test cultures were sensitive to compound II at concentrations of 1,25-0,039 μg/ml. Similar MIC (0,039 μg/ml) of compounds II and I were set for E. coli k88a and S. aureus k99 test cultures -0,156 μg/ml. Only S. aureus ATCC 25923 and K. pneumonia k56 had sensitivity to ceftriaxone (MIC = 0,097 μg/ml). Antiviral activity of Trifuzol (piperidine 2-[5-(furan-2-il)-4-phenil-1,2,4-triazol-3ilthio]acetate) and avistim (morpholines 3-(4-pyridyl)-1,2,4-triazolil-5-thioacetate) against the chicken infectious bronchitis virus (VIB) strain 4/91 was characterized by a decrease in mortality and pathological changes of chicken embryos (CE) which were induced by the virus. Death of infected CE provoked by the strain 4/91 of VIB in dilution 10 -3 occurred at 57.1%. The reduction in the percentage of deaths of CE infected by the virus in dilution 10 -3 in the presence of Avistim was 28.6%, and with Trifuzol 14.3%. The use of avistim and Trifuzol compounds reduced VIB infectious activity when it was cultivated in CE, reducing the titre of the virus (strain 4/91) by 3 lg EID 50 cm -3 .

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“…1,2,4-thiazole and its substituted derivatives rightfully occupy leading positions among the diversity of new synthetic molecules [3,4]. Possessing a wide spectrum of biological properties, 1,2,4-triazoles are low-toxic substances [5].…”

Section: Introductionmentioning

confidence: 99%

Some aspects of clinical trial of the drug “Vetmicoderm”

Ogloblina M. V,

Bushueva I. V,

Martynyshyn V. P

et al. 2024

World J. Bio. Pharm. Health Sci.

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Our aim was to conduct some clinical trials of the drug «Vetmikoderm» and compare its effectiveness with the well-known agent «Triosan». Clinical trials to determine the therapeutic effectiveness of the drug «Vetmikoderm» were carried out at the veterinary clinic «BEST» (Zaporizhzhia) on two groups of dogs, formed by gradual recruitment (based on the owners' referral to the clinic). To determine the etiological factors contributing to the development of dermatosis, we conducted a study of skin microflora. The sensitivity of microorganisms and fungi to the action of the «Vetmikoderm» preparation was determined by the disc-diffusion method. In the process of diagnostic research, including microbiological studies, it was established that conditionally pathogenic microflora from affected areas of dogs' skin was represented by both microorganisms and fungi. At the same time, fungi prevailed in the microbiocenosis of the selected skin samples. It is worth noting that «Vetmikoderm» has a better fungicidal effect, while «Triosan» is evidently more effective in treating dermatoses with predominantly microbial contamination. It has been proven that the combined use of both drugs has a better influence on the recovery process in animals.

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Antimicrobial activity of new 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol derivatives

Cited by 9 publications

References 2 publications

Diuretic activity of some 4- and 3-thio-substituted 1,2,4-triazoles with fluorophenyl fragments

Diuretic activity of some 4- and 3-thio-substituted 1,2,4-triazoles with fluorophenyl fragments

Determination of antimicrobial activity of some 1,2,4-triazole derivatives

Some aspects of clinical trial of the drug “Vetmicoderm”

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