Antimicrobial Activity of Perspiration Pads and Cotton Cloth Fabricated with the Ethyl Acetate Extract of <i>Eichhornia crassipes</i> (Mart.) Solms

Pottail, Lalitha; Jayanthi, P.; R, Sujitha

doi:10.1155/2014/943287

Cited by 7 publications

(6 citation statements)

References 2 publications

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“…The antibacterial efficacy of compounds was determined using the agar disc diffusion technique . A testing culturing medium, Mueller Hington Agar (MHA, Oxoid, England), was used.…”

Section: Methodsmentioning

confidence: 99%

“…The antibacterial efficacy of compounds was determined using the agar disc diffusion technique. 40 A testing culturing medium, Mueller Hington Agar (MHA, Oxoid, England), was used. 1 mg of each inhibitor was dissolved in 1 mL of DMSO to make compound stock solutions (dimethyl sulfoxide, Duksan pure chemicals, Korea).…”

Section: Experimental Testing 221 Antibacterial Disc Diffusion Assaymentioning

confidence: 99%

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Non-β Lactam Inhibitors of the Serine β-Lactamase blaCTX-M15 in Drug-Resistant Salmonella typhi

Ahmad,

Parvaiz,

MacKerell

et al. 2023

J. Chem. Inf. Model.

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Antibiotic resistance by bacterial pathogens against widely used β-lactam drugs is a major concern to public health worldwide, resulting in high healthcare cost. The present study aimed to extend previous research by investigating the potential activity of reported compounds against the S. typhi β-lactamase protein. 74 compounds from computational screening reported in our previous study against β-lactamase CMY-10 were subjected to docking studies against blaCTX-M15. Site-Identification by Ligand Competitive Saturation (SILCS)-Monte Carlo (SILCS-MC) was applied to the top two ligands selected from molecular docking studies to predict and refine their conformations for binding conformations against blaCTX-M15. The SILCS-MC method predicted affinities of −8.6 and −10.7 kcal/mol for Top1 and Top2, respectively, indicating low micromolar binding to the blaCTX-M15 active site. MD simulations initiated from SILCS-MC docked orientations were carried out to better characterize the dynamics and stability of the complexes. Important interactions anchoring the ligand within the active site include pi−pi stacked, amide−pi, and pi−alkyl interactions. Simulations of the Top2− blaCTX-M15 complex exhibited stability associated with a wide range of hydrogen-bond and aromatic interactions between the protein and the ligand. Experimental β-lactamase (BL) activity assays showed that Top1 has 0.1 u/mg BL activity, and Top2 has a BL activity of 0.038 u/mg with a minimum inhibitory concentration of 1 mg/mL. The inhibitors proposed in this study are non-βlactam-based β-lactamase inhibitors that exhibit the potential to be used in combination with β-lactam antibiotics against multidrugresistant clinical isolates. Thus, Top1 and Top2 represent lead compounds that increase the efficacy of β-lactam antibiotics with a low dose concentration.

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“…The antibacterial efficacy of compounds was determined using the agar disc diffusion technique . A testing culturing medium, Mueller Hington Agar (MHA, Oxoid, England), was used.…”

Section: Methodsmentioning

confidence: 99%

Section: Experimental Testing 221 Antibacterial Disc Diffusion Assaymentioning

confidence: 99%

Non-β Lactam Inhibitors of the Serine β-Lactamase blaCTX-M15 in Drug-Resistant Salmonella typhi

Ahmad,

Parvaiz,

MacKerell

et al. 2023

J. Chem. Inf. Model.

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“…The uncoated textile was taken as a control against both strains to compare the antibacterial efficacy of the nanoencapsulated finished cotton textile fabricated with the layer-by-layer coating of the antifouling polymeric formulation (APF). The antibacterial efficacy of fabricated finished textile was analyzed by placing the textile swatches (40 × 10 mm) in intimate contact on agar plates prestreaked with bacterial inoculum [50]. A clear zone of inhibition was observed around the modified textiles coated with 1, 5, 10, 15, and 20 bilayers.…”

Section: Antibacterial Assay Of Textile Fabricmentioning

confidence: 99%

Layer-By-Layer Self-Assembled Dip Coating for Antifouling Functionalized Finishing of Cotton Textile

et al. 2022

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The fouling of surfaces such as textiles is a major health challenge, and there is a continuous effort to develop materials and processes to overcome it. In consideration of this, this study regards the development of antifouling functional nanoencapsulated finishing for the cotton textile fabric by employing a layer-by-layer dip coating technique. Antifouling textile finishing was formulated by inducing the nanoencapsulation of the antifouling functional group inside the hydrophobic polymeric shell. Cotton fabric was taken as a substrate to incorporate antibacterial functionality by alternatively fabricating multilayers of antifouling polymeric formulation (APF) and polyelectrolyte solution. The surface morphology of nanoencapsulated finished textile fabric was characterized through scanning electron microscopy to confirm the uniform distribution of nanoparticles on the cotton textile fabric. Optical profilometry and atomic force microscopy studies indicated increased surface roughness in the coated textile substrate as compared to the uncoated textile. The surface thickness of the fabricated textile increased with the number of deposited bilayers on the textile substrate. Surface hydrophobicity increased with number of coating bilayers with θ values of x for single layer, up to y for 20 bilayers. The antibacterial activity of the uncoated and layer-by-layer coated finished textile was also evaluated. It was significant and exhibited a significant zone of inhibition against microbial strains Gram-positive S. aureus and Gram-negative E. coli. The bilayer coating exhibited water repellency, hydrophobicity, and antibacterial activity. Thus, the fabricated textile could be highly useful for many industrial and biomedical applications.

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“…Scientists are leveraging advanced technologies and methodologies to identify and characterize these substances and evaluate their efficacy against different diseases. These efforts hold great promise for the development of new drugs and treatments that can address the pressing health issues facing our global population [1] . Medicinal plants, in particular, have long been recognized as a promising source for drug discovery diverse range of diseases [2] .…”

Section: Introductionmentioning

confidence: 99%

“…They have demonstrated various beneficial properties, including antioxidant, anti-inflammatory, antimicrobial, antiviral, and anticancer activities. Their potential as therapeutic agents has led to extensive research into their mechanisms of action and applications in preventing and treating diseases [1] . The exploration and understanding of phytochemicals have been instrumental in drug discovery and the development of natural remedies for various diseases.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and antioxidant potential of the crude extracts of Ipomoea quamoclit

Sultana¹,

Sarker²

2023

J. Med. Plants Stud.

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The emergence of new chronic and infectious diseases has spurred intense research efforts to identify new and effective substances for combating these global health challenges. Plants have been widely acknowledged as a principal source of drug discovery due to their remarkable ability to produce a diverse array of bioactive molecules. Thus, this study aimed to investigate the phytochemical and antioxidant potential of the crude extracts obtained from different parts of Ipomoea quamoclit. Various parts of I. quamoclit were collected, ground, dried, and processed into a coarse powder. Subsequently, solvent extraction using methanol and ethyl acetate was performed to obtain the extracts. The methanolic extract (ME) of the plant's leaves exhibited a higher phenolic content (6.097±0.189 mg/g of GAE) compared to the ME of the root (4.515±0.1884 mg/g of GAE). Additionally, the ethyl acetate extract (EAE) of the leaves showed a higher flavonoid content (12.815±0.234 mg/g of CAE) compared to the EAE of the root (11.229±3.558 mg/g of CAE). Moreover, the ME of the stem displayed a higher antioxidant capacity (41.488±0.684 mg/g of AAE) than the ME of the leaves (37.133±5.604 mg/g of AAE). The DPPH radical scavenging activity of the ME of the stem of I. quamoclit was 64.050%, comparable to that of BHT (77.48%). These findings indicate that I. quamoclit holds promise as a valuable source of phytochemicals and antioxidant compounds.

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Antimicrobial Activity of Perspiration Pads and Cotton Cloth Fabricated with the Ethyl Acetate Extract of Eichhornia crassipes (Mart.) Solms

Cited by 7 publications

References 2 publications

Non-β Lactam Inhibitors of the Serine β-Lactamase blaCTX-M15 in Drug-Resistant Salmonella typhi

Non-β Lactam Inhibitors of the Serine β-Lactamase blaCTX-M15 in Drug-Resistant Salmonella typhi

Layer-By-Layer Self-Assembled Dip Coating for Antifouling Functionalized Finishing of Cotton Textile

Phytochemical and antioxidant potential of the crude extracts of Ipomoea quamoclit

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